Evaluation of the clinical efficiency of lokivetmab in client privately owned atopic dogs - multicenter study.

Atopic dermatitis (AD) is the most frequent allergic disease in dogs. AD can be treated using allergenspecific immunotherapy as well as symptomatic antipruritic treatment including the use of lokivetmab - caninized anti-interleukine-31 antibody.The aim of the study was to evaluate the effectiveness of lokivetmab over 12 weeks of treat-ment. Studies have been carried out in 89 dogs. In all affected animals, the severity of lesions was assessed using the CADESI 04 and the pruritus was assessed using the VAS.After the first dose of lokivetmab, both CADESI 04 and VAS statistical decreased by 4 weeks from 40.48 to 20.31, and from 7.42 to 2.48, respectively (p = 0.0000001) maintained significantly decresed values during the whole treatment period (CADESI 04 15.64, 15.07 after 8 and 12 weeks, respectively, PVAS 2.03, 1.95 after 8 and 12 weeks, respectively).Lokivetmab leads to a significant reduction of CADESI 04 and pruritus, within four weeks and maximum effect is achived after the second dose.

Experimental demonstration of an electromagnetic pulse mitigation concept for a laser driven proton source.

The targets that are used to produce high-energy protons with ultra-high intensity lasers generate a strong electromagnetic pulse (EMP). To mitigate that undesired side effect, we developed and tested a concept called the "birdhouse." It consists in confining the EMP field in a finite volume and in dissipating the trapped electromagnetic energy with an electric resistor. A prototype was tested at a 10 TW 50 fs laser facility. The recorded average EMP mitigation ratio is about 20 for frequencies from 100 MHz to 6 GHz. The EMP mitigation ratio attains the level of 50 in the frequency range of 1-2 GHz where microwave emission is maximal. We measured the intensity of proton emission in two directions: along the laser propagation direction and along the edge of the proton beam. We observed that the "birdhouse" induces a two-fold increase of the intensity in the center of the proton beam and a two-fold reduction of the intensity on its edge. We did not observe any modification of the proton beam normalized spectrum.

Magnetized plasma implosion in a snail target driven by a moderate-intensity laser pulse.

Optical generation of compact magnetized plasma structures is studied in the moderate intensity domain. A sub-ns laser beam irradiated snail-shaped targets with the intensity of about 1016 W/cm2. With a neat optical diagnostics, a sub-megagauss magnetized plasmoid is traced inside the target. On the observed hydrodynamic time scale, the hot plasma formation achieves a theta-pinch-like density and magnetic field distribution, which implodes into the target interior. This simple and elegant plasma magnetization scheme in the moderate-intensity domain is of particular interest for fundamental astrophysical-related studies and for development of future technologies.

Shot-to-shot reproducibility in the emission of fast highly charged metal ions from a laser ion source.

The generation of fast highly charged metal ions with the use of the sub-nanosecond Prague Asterix Laser System, operated at a fundamental wavelength of 1315 nm, is reported. Particular attention is paid to shot-to-shot reproducibility in the ion emission. Au and Pd targets were exposed to intensities up to 5 × 10(16) W∕cm(2). Above the laser intensity threshold of ∼3 × 10(14) W∕cm(2) the plasma is generated in a form of irregular bursts. The maximum energy of protons constituting the leading edge of the fastest burst reaches a value up to 1 MeV. The fast ions in the following bursts have energy gradually decreasing with the increasing burst number, namely, from a value of about 0.5 MeV∕charge regardless of the atomic number and mass of the ionized species.

Laser produced streams of Ge ions accelerated and optimized in the electric fields for implantation into SiO2 substrates.

Ge crystals were prepared by means of laser-induced ion implantation technique. A Nd:YAG pulsed laser (repetition rate: 10 Hz; pulse duration: 3.5 ns; pulse energy: ∼0.5 J) was used both as an ion source and to carry out the ablation processes. The optimization of the laser-generated ion beam parameters in a broad energy and current density range has been obtained controlling the electrostatic field parameters. Numerical simulations of the focusing system, performed adopting an OPERA 3D code, and an investigation of the ion characteristics, using the ion time-of-flight method, have allowed to optimize the preparation parameters. The structural properties of the samples were investigated by means of x-ray photoelectron, micro-Raman spectroscopies, and scanning electron microscopy techniques. Experimental results show that, by appropriately varying the ion implantation parameters and by a post-preparation annealing treatment, it is possible to achieve the development of a micrometer-sized crystalline Ge phase and∕or an amorphous one.

New methods for high current fast ion beam production by laser-driven acceleration.

An overview of the last experimental campaigns on laser-driven ion acceleration performed at the PALS facility in Prague is given. Both the 2 TW, sub-nanosecond iodine laser system and the 20 TW, femtosecond Ti:sapphire laser, recently installed at PALS, are used along our experiments performed in the intensity range 10(16)-10(19) W∕cm(2). The main goal of our studies was to generate high energy, high current ion streams at relatively low laser intensities. The discussed experimental investigations show promising results in terms of maximum ion energy and current density, which make the laser-accelerated ion beams a candidate for new-generation ion sources to be employed in medicine, nuclear physics, matter physics, and industry.

Fast proton generation from ultrashort laser pulse interaction with double-layer foil targets.

The results of studies of fast-proton generation from foil targets irradiated by 1-ps laser pulse at 10(17) W/cm (2) are presented. It is shown that a considerable increase in proton energy and current is possible when a double-layer foil target containing a high- Z layer and a low- Z hydrogen-rich layer is used instead of a single-layer target. Proton energies and current increase with the Z of the high- Z layer and depend essentially on the target and the layer thicknesses. Above 10(9) forward-emitted protons of energy >100 keV have been recorded within a cone angle <3 degrees.