Systematic Evaluation of Imaging Features of Early Bladder Cancer Using Computed Tomography Performed before Pathologic Diagnosis.

BACKGROUND: Bladder cancer is the sixth most common malignancy in the United States (US). Despite its high prevalence and the significant potential benefits of early detection, no reliable, cost-effective screening algorithm exists for asymptomatic patients at risk. Nonetheless, reports of incidentally identified early bladder cancer on CT/MRI scans performed for other indications are emerging in the literature. This represents a new opportunity for early detection, with over 80 million CT scans performed in the US yearly, 40% of which are abdominopelvic CTs. This investigation aims to define the imaging features of early bladder cancer, with the mission of facilitating early diagnosis. METHODS: Following IRB approval with a waiver of informed consent, a retrospective review was performed, identifying 624 patients with non-muscle-invasive bladder cancer diagnosed at Johns Hopkins Hospital between 2000 and 2019. Of these patients, 99 patients underwent pelvic CT within the 5 years preceding pathologic diagnosis. These imaging studies were reviewed retrospectively to evaluate for the presence and features of any focal bladder wall abnormality. RESULTS: Median age at the time of pathologic diagnosis was 70 years (range: 51-88 years), and 82% (81/99) of patients were male. A total of 226 CT studies were reviewed. The number of studies per patient ranged from 1 to 33. Median time interval between all available imaging and pathologic diagnosis was 14 months. A total of 62% (141/226) of the scans reviewed were performed for indications other than suspected urinary tract cancer (UTC). A bladder wall mass was visualized in 67% (66/99) of patients and on 35% (78/226) of scans performed before diagnosis. The majority (84%, 67/80) of masses were intraluminal. Mean transverse long- and short-axis measurements were 24 mm and 17 mm, respectively, with long dimension measurements ranging between 5 and 59 mm. CONCLUSIONS: Early bladder cancer was visualized on CT preceding pathologic diagnosis in more than 2/3 of patients, and the majority of scans were performed for indications other than suspected urinary tract cancer/UTC symptoms. These results suggest that cross-sectional imaging performed for other indications can serve as a resource for opportunistic bladder cancer screening, particularly in high-risk patients.

Factors affecting perception of the normal pediatric appendix on sonography.

BACKGROUND: To determine if an inherent perception skill along with sonographer experience, knowledge base, scanning time play a role in the identification of the normal appendix in the pediatric population. This is a retrospective review of pediatric (< 18 years old) patients with a clinical suspicion of acute appendicitis presenting to the emergency department of two affiliated academic tertiary care hospitals over a 1-year time span. All patients had a sonogram performed by 1/15 sonographers or by 1/8 on-call radiology residents. Those with a normal or non-visualized appendix with subsequent discharge from ER were included in the study. Patient demographics, minutes spent scanning, and sonographer years of experience in general abdominal scanning and residents level of training were recorded. RESULTS: Of the 127 patients included in the study, 51 (40%) were male and 76 (60%) were female, with a mean age of 11.8 ± 4.2 years. Sonographers who failed to see a normal appendix had less experience (median 8 years) than those who did visualize the appendix (median 15 years), p ≤ 0.001. Longer time spent scanning was also associated with visualizing a normal appendix (20.4 versus 29.1 min, p = 0.001). In multivariable logistic regression, more time spent scanning (OR 1.04, 95% CI 1.01, 1.07, p = 0.012) and increased sonographer experience (OR 1.07, 95% CI 1.02, 1.13, p = 0.012) resulted in greater odds of perceiving the appendix. The top 4 were significantly more likely to visualize the appendix (88.0%) than all of the other combined (20.8%, p < 0.001), and they also had substantially more experience (median 15 years versus 8 years, p < 0.001). Overall, sonographers were more likely to see a normal appendix (61%) than the residents (14%), p < 0.001. CONCLUSION: Sonography to rule out appendicitis in the pediatric patient is in general most successful when performed by experienced sonographers with adequate time to perform the scan. Triaging patients to those sonographers who have displayed optimal perceptual ability of the normal appendix may help optimize patient care and hospital resources. Having experienced sonographers available after hours would allow for optimal care in the setting of 'query' appendicitis.

Tuberculous osteomyelitis/arthritis of the first costo-clavicular joint and sternum.

A young Somali immigrant presents with a two-year history of a large, firm, painful right anterolateral chest wall sternal mass. The patient denied any history of trauma or infection at the site and did not have a fever, erythematous lesion at the site, clubbing, or lymphadenopathy. A lateral chest radiograph demonstrated a low density mass isolated to the subcutaneous soft tissue overlying the sternum, ribs and clavicle. Computed tomography (CT) with contrast demonstrated a cystic lesion in the right anterolateral chest wall deep to the pectoralis muscle. Enhanced CT of the chest demonstrated sclerosis and destruction of the rib and costochondral joint and manubrio-sternal joint narrowing. Ultrasound-guided biopsy and aspiration returned 500 cc of purulent, cloudy yellow, foul-smelling fluid. Acid-fact bacilli stain and the nucleic acid amplification test identified and confirmed Mycobacterium tuberculosis. A diagnosis of tuberculous osteomyelitis/septic arthritis was made and antibiotic coverage for tuberculosis was initiated.