1.
Am J Geriatr Psychiatry
; 32(5): 644-645, 2024 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38216356
2.
Mol Cell Endocrinol
; 418 Pt 3: 298-305, 2015 Dec 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26184856
RESUMO
The F domain located at the C-terminus of proteins is one of the least conserved regions of the estrogen receptors alpha and beta, members of the nuclear hormone receptor superfamily. Indeed, many members of the superfamily lack the F domain. However, when present, removing the F domain entirely or mutating it alters transactivation, dimerization, and the responses to agonist and antagonist ligands. This review focuses on the functions of the F domain of the estrogen receptors, particularly in relation to other members of the superfamily.