Detalhe da pesquisa
1.
Tumor-targeting bacteria as immune stimulants - the future of cancer immunotherapy?
Crit Rev Microbiol
; : 1-16, 2024 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38346140
2.
Directed evolution of the B. subtilis nitroreductase YfkO improves activation of the PET-capable probe SN33623 and CB1954 prodrug.
Biotechnol Lett
; 43(1): 203-211, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-32851465
3.
Design, Synthesis and In-Vitro Biological Evaluation of Antofine and Tylophorine Prodrugs as Hypoxia-Targeted Anticancer Agents.
Molecules
; 26(11)2021 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34206005
4.
Alanine scan-guided synthesis and biological evaluation of analogues of culicinin D, a potent anticancer peptaibol.
Bioorg Med Chem Lett
; 30(11): 127135, 2020 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32229061
5.
Synthesis and antiproliferative activity of C- and N-terminal analogues of culicinin D.
Bioorg Med Chem Lett
; 30(16): 127331, 2020 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32631536
6.
Subcellular Location of Tirapazamine Reduction Dramatically Affects Aerobic but Not Anoxic Cytotoxicity.
Molecules
; 25(21)2020 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33105798
7.
Engineering Escherichia coli NfsB To Activate a Hypoxia-Resistant Analogue of the PET Probe EF5 To Enable Non-Invasive Imaging during Enzyme Prodrug Therapy.
Biochemistry
; 58(35): 3700-3710, 2019 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31403283
8.
Prototyping kinase inhibitor-cytotoxin anticancer mutual prodrugs activated by tumour hypoxia: A chemical proof of concept study.
Bioorg Med Chem Lett
; 29(10): 1215-1219, 2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30885680
9.
Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility.
Biochem J
; 471(2): 131-53, 2015 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26431849
10.
Binding mode of the breakthrough inhibitor AZD9291 to epidermal growth factor receptor revealed.
J Struct Biol
; 192(3): 539-544, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26522274
11.
Zinc finger nuclease knock-out of NADPH:cytochrome P450 oxidoreductase (POR) in human tumor cell lines demonstrates that hypoxia-activated prodrugs differ in POR dependence.
J Biol Chem
; 288(52): 37138-53, 2013 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24196959
12.
Characterisation of radicals formed by the triazine 1,4-dioxide hypoxia-activated prodrug, SN30000.
Org Biomol Chem
; 12(21): 3386-92, 2014 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24737463
13.
Bioreductive prodrugs as cancer therapeutics: targeting tumor hypoxia.
Chin J Cancer
; 33(2): 80-6, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23845143
14.
Clostridium Bacteria: Harnessing Tumour Necrosis for Targeted Gene Delivery.
Mol Diagn Ther
; 28(2): 141-151, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38302842
15.
Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity.
J Med Chem
; 67(4): 2667-2689, 2024 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38348819
16.
Pseudomonas aeruginosa NfsB and nitro-CBI-DEI--a promising enzyme/prodrug combination for gene directed enzyme prodrug therapy.
Mol Cancer
; 12: 58, 2013 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-23758947
17.
Synthesis and cytotoxicity of pyranonaphthoquinone natural product analogues under bioreductive conditions.
Bioorg Med Chem
; 21(24): 7971-80, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24436995
18.
Structural Mechanism and Inhibitors Targeting EGFR Exon 20 Insertion (Ex20ins) Mutations.
J Med Chem
; 66(17): 11656-11671, 2023 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37669428
19.
Design and Biological Evaluation of Piperazine-Bearing Nitrobenzamide Hypoxia/GDEPT Prodrugs: The Discovery of CP-506.
ACS Med Chem Lett
; 14(11): 1517-1523, 2023 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37974941
20.
Diflavin oxidoreductases activate the bioreductive prodrug PR-104A under hypoxia.
Mol Pharmacol
; 81(1): 31-40, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21984255