Pesquisa | Portal de Pesquisa da BVS

1.

Naturally Occurring Off-Switches for CRISPR-Cas9.

Pawluk, April; Amrani, Nadia; Zhang, Yan; Garcia, Bianca; Hidalgo-Reyes, Yurima; Lee, Jooyoung; Edraki, Alireza; Shah, Megha; Sontheimer, Erik J; Maxwell, Karen L; Davidson, Alan R.

Cell ; 167(7): 1829-1838.e9, 2016 Dec 15.

Artigo em Inglês | MEDLINE | ID: mdl-27984730

2.

Finding Common Ground.

Pawluk, April.

Cell ; 177(6): 1361-1363, 2019 05 30.

Artigo em Inglês | MEDLINE | ID: mdl-31150613

3.

CRISPR: No Sign of Slowing Down.

Pawluk, April.

Cell ; 174(5): 1039-1041, 2018 08 23.

Artigo em Inglês | MEDLINE | ID: mdl-30142340

4.

Breaking the Rules.

Pawluk, April.

Cell ; 173(4): 805-807, 2018 05 03.

Artigo em Inglês | MEDLINE | ID: mdl-29727666

5.

Discovery of bioactive microbial gene products in inflammatory bowel disease.

Zhang, Yancong; Bhosle, Amrisha; Bae, Sena; McIver, Lauren J; Pishchany, Gleb; Accorsi, Emma K; Thompson, Kelsey N; Arze, Cesar; Wang, Ya; Subramanian, Ayshwarya; Kearney, Sean M; Pawluk, April; Plichta, Damian R; Rahnavard, Ali; Shafquat, Afrah; Xavier, Ramnik J; Vlamakis, Hera; Garrett, Wendy S; Krueger, Andy; Huttenhower, Curtis; Franzosa, Eric A.

Nature ; 606(7915): 754-760, 2022 06.

Artigo em Inglês | MEDLINE | ID: mdl-35614211

6.

Tiny Answers to Big Questions.

Pawluk, April.

Cell ; 170(2): 215-217, 2017 07 13.

Artigo em Inglês | MEDLINE | ID: mdl-28708991

7.

Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system.

Bondy-Denomy, Joe; Pawluk, April; Maxwell, Karen L; Davidson, Alan R.

Nature ; 493(7432): 429-32, 2013 Jan 17.

Artigo em Inglês | MEDLINE | ID: mdl-23242138

8.

Bridge RNAs direct modular and programmable recombination of target and donor DNA.

Durrant, Matthew G; Perry, Nicholas T; Pai, James J; Jangid, Aditya R; Athukoralage, Januka S; Hiraizumi, Masahiro; McSpedon, John P; Pawluk, April; Nishimasu, Hiroshi; Konermann, Silvana; Hsu, Patrick D.

bioRxiv ; 2024 Jan 26.

Artigo em Inglês | MEDLINE | ID: mdl-38328150

9.

Deep learning and CRISPR-Cas13d ortholog discovery for optimized RNA targeting.

Wei, Jingyi; Lotfy, Peter; Faizi, Kian; Baungaard, Sara; Gibson, Emily; Wang, Eleanor; Slabodkin, Hannah; Kinnaman, Emily; Chandrasekaran, Sita; Kitano, Hugo; Durrant, Matthew G; Duffy, Connor V; Pawluk, April; Hsu, Patrick D; Konermann, Silvana.

Cell Syst ; 14(12): 1087-1102.e13, 2023 12 20.

Artigo em Inglês | MEDLINE | ID: mdl-38091991

10.

Alterations in the gut microbiome implicate key taxa and metabolic pathways across inflammatory arthritis phenotypes.

Thompson, Kelsey N; Bonham, Kevin S; Ilott, Nicholas E; Britton, Graham J; Colmenero, Paula; Bullers, Samuel J; McIver, Lauren J; Ma, Siyuan; Nguyen, Long H; Filer, Andrew; Brough, India; Pearson, Claire; Moussa, Caroline; Kumar, Vinod; Lam, Lilian H; Jackson, Matthew A; Pawluk, April; Kiriakidis, Serafim; Taylor, Peter C; Wedderburn, Lucy R; Marsden, Brian; Young, Stephen P; Littman, Dan R; Faith, Jeremiah J; Pratt, Arthur G; Bowness, Paul; Raza, Karim; Powrie, Fiona; Huttenhower, Curtis.

Sci Transl Med ; 15(706): eabn4722, 2023 07 26.

Artigo em Inglês | MEDLINE | ID: mdl-37494472

11.

Anti-CRISPR AcrIE2 Binds the Type I-E CRISPR-Cas Complex But Does Not Block DNA Binding.

Mejdani, Marios; Pawluk, April; Maxwell, Karen L; Davidson, Alan R.

J Mol Biol ; 433(3): 166759, 2021 02 05.

Artigo em Inglês | MEDLINE | ID: mdl-33338493

12.

Anti-CRISPR: discovery, mechanism and function.

Pawluk, April; Davidson, Alan R; Maxwell, Karen L.

Nat Rev Microbiol ; 16(1): 12-17, 2018 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-29062071

13.

Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins.

Lee, Jooyoung; Mir, Aamir; Edraki, Alireza; Garcia, Bianca; Amrani, Nadia; Lou, Hannah E; Gainetdinov, Ildar; Pawluk, April; Ibraheim, Raed; Gao, Xin D; Liu, Pengpeng; Davidson, Alan R; Maxwell, Karen L; Sontheimer, Erik J.

mBio ; 9(6)2018 12 04.

Artigo em Inglês | MEDLINE | ID: mdl-30514786

14.

Disabling a Type I-E CRISPR-Cas Nuclease with a Bacteriophage-Encoded Anti-CRISPR Protein.

Pawluk, April; Shah, Megha; Mejdani, Marios; Calmettes, Charles; Moraes, Trevor F; Davidson, Alan R; Maxwell, Karen L.

mBio ; 8(6)2017 12 12.

Artigo em Inglês | MEDLINE | ID: mdl-29233895

15.

Inactivation of CRISPR-Cas systems by anti-CRISPR proteins in diverse bacterial species.

Pawluk, April; Staals, Raymond H J; Taylor, Corinda; Watson, Bridget N J; Saha, Senjuti; Fineran, Peter C; Maxwell, Karen L; Davidson, Alan R.

Nat Microbiol ; 1(8): 16085, 2016 06 13.

Artigo em Inglês | MEDLINE | ID: mdl-27573108

16.

A new group of phage anti-CRISPR genes inhibits the type I-E CRISPR-Cas system of Pseudomonas aeruginosa.

Pawluk, April; Bondy-Denomy, Joseph; Cheung, Vivian H W; Maxwell, Karen L; Davidson, Alan R.

mBio ; 5(2): e00896, 2014 Apr 15.

Artigo em Inglês | MEDLINE | ID: mdl-24736222

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Naturally Occurring Off-Switches for CRISPR-Cas9.

Finding Common Ground.

CRISPR: No Sign of Slowing Down.

Breaking the Rules.

Discovery of bioactive microbial gene products in inflammatory bowel disease.

Tiny Answers to Big Questions.

Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system.

Bridge RNAs direct modular and programmable recombination of target and donor DNA.

Deep learning and CRISPR-Cas13d ortholog discovery for optimized RNA targeting.

Alterations in the gut microbiome implicate key taxa and metabolic pathways across inflammatory arthritis phenotypes.

Anti-CRISPR AcrIE2 Binds the Type I-E CRISPR-Cas Complex But Does Not Block DNA Binding.

Anti-CRISPR: discovery, mechanism and function.

Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins.

Disabling a Type I-E CRISPR-Cas Nuclease with a Bacteriophage-Encoded Anti-CRISPR Protein.

Inactivation of CRISPR-Cas systems by anti-CRISPR proteins in diverse bacterial species.

A new group of phage anti-CRISPR genes inhibits the type I-E CRISPR-Cas system of Pseudomonas aeruginosa.