Detalhe da pesquisa
1.
Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming.
Nat Chem Biol
; 16(10): 1052-1061, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32690944
2.
Divergent Proteome Reactivity Influences Arm-Selective Activation of Pharmacological Endoplasmic Reticulum Proteostasis Regulators.
bioRxiv
; 2023 Jan 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36712115
3.
Divergent Proteome Reactivity Influences Arm-Selective Activation of the Unfolded Protein Response by Pharmacological Endoplasmic Reticulum Proteostasis Regulators.
ACS Chem Biol
; 18(8): 1719-1729, 2023 08 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37523656
4.
Blinded potency comparison of transthyretin kinetic stabilisers by subunit exchange in human plasma.
Amyloid
; 28(1): 24-29, 2021 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-32811187
5.
Pharmacologic targeting of plasma cell endoplasmic reticulum proteostasis to reduce amyloidogenic light chain secretion.
Blood Adv
; 5(4): 1037-1049, 2021 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-33599742
6.
Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis.
Nat Commun
; 10(1): 187, 2019 01 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30643122
7.
Modulating protein quality control.
Elife
; 52016 07 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27435959
8.
Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation.
Elife
; 52016 07 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27435961