Detalhe da pesquisa
1.
Ontogeny of Scaling Factors for Pediatric Physiologically Based Pharmacokinetic Modeling and Simulation: Cytosolic Protein Per Gram of Liver.
Drug Metab Dispos
; 51(12): 1578-1582, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37735064
2.
Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver.
Drug Metab Dispos
; 50(1): 24-32, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34686522
3.
The Impact of Age and Genetics on Naltrexone Biotransformation.
Drug Metab Dispos
; 50(2): 168-173, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34728519
4.
Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism.
Drug Metab Dispos
; 47(8): 818-831, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31101678
5.
Evaluating metronidazole as a novel, safe CYP2A6 phenotyping probe in healthy adults.
Br J Clin Pharmacol
; 85(5): 960-969, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30706508
6.
Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.
Drug Metab Dispos
; 46(6): 888-896, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29602798
7.
Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver.
J Pharmacol Exp Ther
; 363(2): 265-274, 2017 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28819071
8.
Age-dependent Protein Abundance of Cytosolic Alcohol and Aldehyde Dehydrogenases in Human Liver.
Drug Metab Dispos
; 45(9): 1044-1048, 2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28607029
9.
Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants.
Drug Metab Dispos
; 45(2): 216-223, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27895113
10.
Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children.
Drug Metab Dispos
; 44(7): 1070-9, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27052878
11.
Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation.
Drug Metab Dispos
; 44(7): 948-58, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26608082
12.
In Vitro Hepatic Oxidative Biotransformation of Trimethoprim.
Drug Metab Dispos
; 43(9): 1372-80, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26138612
13.
Variability in Expression of CYP3A5 in Human Fetal Liver.
Drug Metab Dispos
; 43(8): 1286-93, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25979262
14.
Urinary biomarkers of trimethoprim bioactivation in vivo following therapeutic dosing in children.
Chem Res Toxicol
; 27(2): 211-8, 2014 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-24380396
15.
Influence of novel CYP2C-haplotype on proton pump inhibitor pharmacokinetics in children.
Clin Transl Sci
; 17(4): e13782, 2024 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38629502
16.
The role of human cytochrome P450 enzymes in the formation of 2-hydroxymetronidazole: CYP2A6 is the high affinity (low Km) catalyst.
Drug Metab Dispos
; 41(9): 1686-94, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23813797
17.
The Impact of the CYP2D6 "Enhancer" Single Nucleotide Polymorphism on CYP2D6 Activity.
Clin Pharmacol Ther
; 111(3): 646-654, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34716917
18.
A longitudinal study of cytochrome P450 2D6 (CYP2D6) activity during adolescence.
Clin Transl Sci
; 15(10): 2514-2527, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35997001
19.
Utility of the 13 C-pantoprazole breath test as a CYP2C19 phenotyping probe for children.
Clin Transl Sci
; 15(5): 1155-1166, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35099109
20.
Discovery of the nonfunctional CYP2D6 31 allele in Spanish, Puerto Rican, and US Hispanic populations.
Eur J Clin Pharmacol
; 66(9): 859-64, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20473659