Detalhe da pesquisa
1.
Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis.
EMBO J
; 39(21): e105111, 2020 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32945574
2.
Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death.
Blood
; 137(24): 3351-3364, 2021 06 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33512431
3.
Neurokinin-1 receptor is an effective target for treating leukemia by inducing oxidative stress through mitochondrial calcium overload.
Proc Natl Acad Sci U S A
; 116(39): 19635-19645, 2019 09 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31488714
4.
Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma.
Proc Natl Acad Sci U S A
; 116(36): 17990-18000, 2019 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31439820
5.
The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer.
Br J Cancer
; 124(3): 616-627, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33173151
6.
Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers.
Proc Natl Acad Sci U S A
; 115(18): 4737-4742, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29669917
7.
Altered interactions between unicellular and multicellular genes drive hallmarks of transformation in a diverse range of solid tumors.
Proc Natl Acad Sci U S A
; 114(24): 6406-6411, 2017 06 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28484005
8.
Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population.
Blood
; 129(21): 2882-2895, 2017 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28283481
9.
Palbociclib synergizes with BRAF and MEK inhibitors in treatment naïve melanoma but not after the development of BRAF inhibitor resistance.
Int J Cancer
; 142(10): 2139-2152, 2018 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29243224
10.
How the evolution of multicellularity set the stage for cancer.
Br J Cancer
; 118(2): 145-152, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29337961
11.
A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes.
Genome Res
; 25(2): 201-12, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25452314
12.
The Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer.
Int J Mol Sci
; 18(1)2017 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28117679
13.
The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy.
Biochim Biophys Acta
; 1849(7): 821-9, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25464032
14.
Autophagy induction is a Tor- and Tp53-independent cell survival response in a zebrafish model of disrupted ribosome biogenesis.
PLoS Genet
; 9(2): e1003279, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23408911
15.
Targeting the nucleolus for cancer intervention.
Biochim Biophys Acta
; 1842(6): 802-16, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24389329
16.
Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas.
Blood
; 121(15): 2964-74, 2013 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23403624
17.
Drosophila ribosomal protein mutants control tissue growth non-autonomously via effects on the prothoracic gland and ecdysone.
PLoS Genet
; 7(12): e1002408, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22194697
18.
Targeting the ribosome to treat multiple myeloma.
Mol Ther Oncol
; 32(1): 200771, 2024 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38596309
19.
ERG and c-MYC regulate a critical gene network in BCR::ABL1-driven B cell acute lymphoblastic leukemia.
Sci Adv
; 10(10): eadj8803, 2024 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38457494
20.
Spatial analysis with SPIAT and spaSim to characterize and simulate tissue microenvironments.
Nat Commun
; 14(1): 2697, 2023 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37188662