Study of endothelial function response to exercise training in hypertensive individuals (SEFRET): study protocol for a randomized controlled trial.

BACKGROUND: Endothelial dysfunction is a hallmark of diabetes mellitus and systemic arterial hypertension (SAH) and an early maker for atherosclerosis. Aerobic exercise training is known to enhance endothelial function, but little is understood about the effects of resistance or combined exercise training on endothelial function. The aim of this study is to investigate the effect of a 12-week aerobic (AT), resistance (RT), or combined (aerobic and resistance, CT) training program on endothelial function and assess associated effects on blood pressure in individuals with SAH. METHODS/DESIGN: Eighty-one subjects with SAH aged 18 to 70 years will be selected and randomly assigned to three types of exercise training: AT, RT or CT. The study will involve the following procedures and tests: anamnesis, anthropometric assessment, echocardiography, blood pressure measurements through ambulatory blood pressure monitoring, flow-mediated dilation, ergospirometry, one repetition maximum test (1-RM), and blood collection (number of circulating endothelial progenitor cells, number of circulating endothelial microparticles, lipid profile, glucose, glycated hemoglobin, and creatinine). The AT intervention will consist of a 40-min exercise session with progressive intensities ranging from 50 to 75% of heart rate reserve. The RT intervention will consist of a 40-minute session with four sets of six to 12 repetitions with a rest period of 60 to 90 seconds between each set and each type of exercise. Weight loads will be adjusted to 60 to 80% of 1-RM for six types of exercise. The CT intervention will consist of a 20-min aerobic exercise session, followed by an additional 20-min resistance exercise session; each resistance exercise will have two sets less to match the total training volume. DISCUSSION: The study results are expected evidence of cardiovascular protective effects of different types of exercise training through the modulation of endothelial function in hypertensive individuals. Knowing the magnitude of improvement of endothelium-dependent vasodilation for the different types of exercise training can provide scientific evidence for the prescription of exercise programs for vascular protection targeting hypertensive individuals. TRIAL REGISTRATION: The Brazilian Clinical Trials Registry ( http://www.ensaiosclinicos.gov.br/) under RBR-9ygmdn and dated 1 March 2015.

Estudo multidimensional das condições de vida do idoso que freqüenta os serviços da Unisc campus Santa Cruz do Sul, RS / Multidimensional study of the life conditions of the elderly who are assisted at UNISC, campus Santa Cruz do Sul/RS

Este texto apresenta parte dos resultado da pesquisa entitulada Estudo multidimensional das condições de vida do idoso que freqüenta os serviços da Unisc - campus de Santa Cruz do Sul, realizada com indivíduos de 60 anos ou mais. O estudo tem por objetivo descrever o perfil biopsicossocial do idoso que freqüenta os serviços da Unisc. Dentre os resultados obtidos, observou-se que os idosos pesquisados estão inseridos na categoria das pessoas que sofrem de doenças não transmissíveis associadas ao estilo de vida.

This paper presents part of the results of the research "Multidimensional Study of the Life Conditions of Elderly People who are assisted at UNISC - Campus Santa Cruz do Sul", carried ou with subjects who are 60 years old or older. The study aims to describe the byopsychosocial profile of the elderly people who are assisted at UNISC. Among the results, we notice that the elderly who were part of the research belong to a group of people who suffer from non-transmissible diseases associate with their life style.