Detalhe da pesquisa
1.
A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease.
J Autoimmun
; 95: 1-14, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30446251
2.
Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs.
Nucleic Acids Res
; 44(16): 7804-16, 2016 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27466392
3.
Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping.
PLoS Genet
; 11(6): e1005272, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-26106896
4.
Human IL-6RhiTIGIT- CD4+CD127lowCD25+ T cells display potent in vitro suppressive capacity and a distinct Th17 profile.
Clin Immunol
; 179: 25-39, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28284938
5.
Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity.
J Autoimmun
; 84: 75-86, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28747257
6.
Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial.
PLoS Med
; 13(10): e1002139, 2016 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-27727279
7.
Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases.
PLoS Genet
; 9(4): e1003444, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23593036
8.
IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients.
Diabetologia
; 58(4): 781-90, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25652388
9.
Sustained in vivo signaling by long-lived IL-2 induces prolonged increases of regulatory T cells.
J Autoimmun
; 56: 66-80, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25457307
10.
Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors.
J Immunol
; 190(6): 2554-66, 2013 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23418630
11.
Thymocyte regulatory variant alters transcription factor binding and protects from type 1 diabetes in infants.
Sci Rep
; 12(1): 14137, 2022 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35986039
12.
Low-dose IL-2 reduces IL-21+ T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes.
Nat Commun
; 13(1): 7324, 2022 11 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36443294
13.
Epigenetic analysis of regulatory T cells using multiplex bisulfite sequencing.
Eur J Immunol
; 45(11): 3200-3, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26420295
14.
Supplementation with Bifidobacterium longum subspecies infantis EVC001 for mitigation of type 1 diabetes autoimmunity: the GPPAD-SINT1A randomised controlled trial protocol.
BMJ Open
; 11(11): e052449, 2021 11 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34753762
15.
Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp620 Risk Allele Drive the Expansion of FOXP3+ Regulatory T Cells and PD-1 Expression.
Front Immunol
; 10: 2606, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31781109
16.
The DILfrequency study is an adaptive trial to identify optimal IL-2 dosing in patients with type 1 diabetes.
JCI Insight
; 3(19)2018 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30282826
17.
Macropinocytic entry of isolated mitochondria in epidermal growth factor-activated human osteosarcoma cells.
Sci Rep
; 7(1): 12886, 2017 10 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29018288
18.
In-depth immunophenotyping data of IL-6R on the human peripheral regulatory T cell (Treg) compartment.
Data Brief
; 12: 676-691, 2017 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-28567438
19.
Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial.
Wellcome Open Res
; 2: 28, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28815218
20.
Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2.
JCI Insight
; 2(16)2017 Aug 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28814669