Neural processes related to negative self-concept in adult and adolescent anorexia nervosa.

OBJECTIVE: Negative self-concept is characteristic of anorexia nervosa (AN), but the neural processes mediating this component of AN is unknown. These studies investigated how valence and social perspectives impact neural processing in both adults and adolescents with AN. METHOD: In an fMRI task, participants evaluated positive and negative adjectives from three social perspectives. Two studies were completed, one in 59 women (healthy, with AN, recovered from AN) and one in 42 adolescents (healthy, with AN). Neural regions of interest (ROIs) related to valence were identified and activations compared across groups and social perspectives. RESULTS: Behaviourally, both adult and adolescent cohorts with AN were less positive during self-evaluations. In the adult study, neural differences related to clinical group and condition were observed in ROIs more responsive to positive social stimuli (medial prefrontal cortex, precuneus, left temporoparietal junction) but not in ROIs more responsive to negative social stimuli. No neural differences in relation to clinical group were observed in the adolescents. CONCLUSIONS: Behavioural differences related to negative self-concept are present in both adolescents and adults with AN, and neural differences, selective for positive social stimuli, were also observed in adults. AN may interfere with neurodevelopmental processes involved in positive self-concept.

Normative feedback and intentions to help friends with bulimic symptoms.

OBJECTIVE: The current study examined accuracy in estimating campus norms for eating disorder (ED) pathology and the impact of normative feedback on intentions to help friends. Participants: The sample included 130 undergraduate women. Method: Participants estimated prevalence of ED pathology and were randomly assigned to normative feedback or a control condition. Vignettes were presented describing bulimic and sleep disorder symptoms. After presentation of each vignette, participants reported sympathy for and intentions to help friends with similar symptoms. Results: Nine ED pathology estimates were significantly higher than comparison values documented in a larger survey of women attending their university in the previous year. Those who received normative feedback reported lower intentions to help and lower sympathy for a student with bulimic symptoms compared to sleep disorder symptoms. Conclusion: Results raise the possibility that normative feedback could reduce support for friends with bulimic symptoms.