Detalhe da pesquisa
1.
Fragment-based lead discovery of indazole-based compounds as AXL kinase inhibitors.
Bioorg Med Chem
; 49: 116437, 2021 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34600239
2.
Combination treatment for myeloproliferative neoplasms using JAK and pan-class I PI3K inhibitors.
J Cell Mol Med
; 17(11): 1397-409, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24251790
3.
Lumefantrine solid dispersions with piperine for the enhancement of solubility, bioavailability and anti-parasite activity.
Int J Pharm
; 628: 122354, 2022 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36341917
4.
First-in-Human Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Rapidly Developed SARS-CoV-2 Therapeutic Antibody, AOD01, in Healthy Adults.
Infect Dis Ther
; 11(5): 1999-2015, 2022 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-36058990
5.
Stepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2.
J Med Chem
; 63(2): 621-637, 2020 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31910010
6.
Correction to "Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3".
ACS Med Chem Lett
; 10(8): 1240, 2019 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31413812
7.
Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3.
ACS Med Chem Lett
; 10(6): 978-984, 2019 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31223458
8.
Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria.
Eur J Med Chem
; 157: 610-621, 2018 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30125722
9.
Fragment-Based Drug Discovery of Potent Protein Kinase C Iota Inhibitors.
J Med Chem
; 61(10): 4386-4396, 2018 05 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29688013
10.
Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia.
J Med Chem
; 61(10): 4348-4369, 2018 05 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29683667
11.
Toward Resolving the Resveratrol Conundrum: Synthesis and in Vivo Pharmacokinetic Evaluation of BCP-Resveratrol.
ACS Med Chem Lett
; 8(5): 516-520, 2017 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28523103
12.
Scaffold Hopping and Optimization of Maleimide Based Porcupine Inhibitors.
J Med Chem
; 60(15): 6678-6692, 2017 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28671458
13.
p53 Maintains Genomic Stability by Preventing Interference between Transcription and Replication.
Cell Rep
; 15(1): 132-146, 2016 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27052176
14.
Structure-Activity Relationship Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 and BCR-ABL1 Inhibitors Targeting Chronic Myeloid Leukemic Cells.
J Med Chem
; 59(7): 3063-78, 2016 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27011159
15.
Feedback regulation on PTEN/AKT pathway by the ER stress kinase PERK mediated by interaction with the Vault complex.
Cell Signal
; 27(3): 436-42, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25530215
16.
Discovery and Optimization of a Porcupine Inhibitor.
J Med Chem
; 58(15): 5889-99, 2015 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26110200
17.
Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer.
Cancer Res
; 73(2): 502-7, 2013 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23188502
18.
Reduction of influenza virus-induced lung inflammation and mortality in animals treated with a phosophodisestrase-4 inhibitor and a selective serotonin reuptake inhibitor.
Emerg Microbes Infect
; 2(8): e54, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26038487
19.
Identification and characterization of a small-molecule inhibitor of Wnt signaling in glioblastoma cells.
Mol Cancer Ther
; 12(7): 1180-9, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23619303
20.
Fragment-based ligand design of novel potent inhibitors of tankyrases.
J Med Chem
; 56(11): 4497-508, 2013 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23672613