1.
Org Biomol Chem
; 12(22): 3744-54, 2014 Jun 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24789544
RESUMO
Aryl ethynyl anthraquinones have been synthesized by Sonogashira cross-coupling and evaluated as telomeric G-quadruplex ligands, by the FRET melting assay, circular dichroism, the DNA synthesis arrest assay and molecular docking. Both the binding properties and G-quadruplex vs. duplex selectivity are controlled by the structures of the aryl ethynyl moieties.