Detalhe da pesquisa
1.
The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia.
Nature
; 615(7954): 920-924, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36922593
2.
Mezigdomide is effective alone and in combination with menin inhibition in preclinical models of KMT2A-r and NPM1c AML.
Blood
; 143(15): 1513-1527, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38096371
3.
The dTAG system for immediate and target-specific protein degradation.
Nat Chem Biol
; 14(5): 431-441, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29581585
4.
Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands.
Nat Chem Biol
; 14(4): 405-412, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29507391
5.
Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma.
Proc Natl Acad Sci U S A
; 113(46): 13162-13167, 2016 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27799547
6.
Novel inhibitors of the histone methyltransferase DOT1L show potent antileukemic activity in patient-derived xenografts.
Blood
; 136(17): 1983-1988, 2020 10 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32575123
7.
Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma.
Proc Natl Acad Sci U S A
; 111(51): E5564-73, 2014 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25512523
8.
Inherent genome instability underlies trisomy 21-associated myeloid malignancies.
Leukemia
; 38(3): 521-529, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38245602
9.
Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts.
Cancer Discov
; 12(7): 1760-1781, 2022 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35405016
10.
A role for Cdc2- and PP2A-mediated regulation of Emi2 in the maintenance of CSF arrest.
Curr Biol
; 17(3): 213-24, 2007 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-17276914
11.
DNA replication checkpoint control of Wee1 stability by vertebrate Hsl7.
J Cell Biol
; 167(5): 841-9, 2004 Dec 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-15583029
12.
A role for PP1 in the Cdc2/Cyclin B-mediated positive feedback activation of Cdc25.
Mol Biol Cell
; 17(4): 1779-89, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16467385
13.
A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia.
Cancer Cell
; 36(6): 660-673.e11, 2019 12 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31821784
14.
Correction to 'Walking with wider steps changes foot placement control, increases kinematic variability and does not improve linear stability'.
R Soc Open Sci
; 5(1): 172000, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29412194
15.
Structure-Guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitors.
J Med Chem
; 61(17): 7785-7795, 2018 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30125504
16.
YAP1-Mediated Suppression of USP31 Enhances NFκB Activity to Promote Sarcomagenesis.
Cancer Res
; 78(10): 2705-2720, 2018 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29490948
17.
Walking with wider steps changes foot placement control, increases kinematic variability and does not improve linear stability.
R Soc Open Sci
; 4(9): 160627, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28989728
18.
PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer.
Cancer Res
; 77(17): 4613-4625, 2017 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28655788
19.
Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer.
Cancer Discov
; 6(9): 1006-21, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27312177
20.
Preclinical antitumor efficacy of selective exportin 1 inhibitors in glioblastoma.
Neuro Oncol
; 17(5): 697-707, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25366336