The involvement of neuroinflammation in an animal model of dementia and depression.

Alzheimer's disease (AD) and depression are inflammatory pathologies, leading to increased inflammatory response and neurotoxicity. Therefore, this study aimed to evaluate the effect of the treatment with fluoxetine and/or galantamine and/or donepezil on the levels of proinflammatory and anti-inflammatory cytokines in a mixed animal model of depression and dementia. Adult male Wistar rats underwent chronic mild stress (CMS) protocol for 40 days and were subjected to stereotaxic surgery for intra-hippocampal administration of amyloid-beta (Aꞵ) peptide or artificial cerebrospinal fluid (ACSF) to mimic the dementia animal model. On the 42nd day, animals were treated with water, galantamine, donepezil, and/or fluoxetine, orally for 17 days. On the 57th and 58th days, the Splash and Y-maze tests for behavior analysis were performed. The frontal cortex and hippocampus were used to analyze the tumor necrosis factor alfa (TNF-α), interleukin 1 beta (IL-1ꞵ), IL-6, and IL-10 levels. The results of this study show that animals subjected to CMS and administration of Aꞵ had anhedonia, cognitive impairment, increased TNF-α and IL-1ꞵ levels in the frontal cortex, and reduced IL-10 levels in the hippocampus. All treatment groups were able to reverse the cognitive impairment. Only donepezil did not decrease the TNF-α levels in the hippocampus. Fluoxetine + galantamine and fluoxetine + donepezil reversed the anhedonia. Fluoxetine reversed the anhedonia and IL-1ꞵ levels in the frontal cortex. In addition, fluoxetine + donepezil reversed the reduction of IL-10 levels in the hippocampus. The results indicate a pathophysiological interaction between AD and depression, and the association of medications in the future may be a possible therapeutic strategy to reduce inflammation, especially the fluoxetine-associated treatments.

Practice recommendations for the role of physiotherapy in the management of sleep disorders: the 2022 Brazilian Sleep Association Guidelines.

This clinical guideline supported by the Brazilian Sleep Association comprises a brief history of the development of Brazilian sleep physiotherapy, outlines the role of the physiotherapist as part of a sleep health team, and describes the clinical guidelines in respect of the management of some sleep disorders by the physiotherapist (including sleep breathing disorders, i.e., obstructive sleep apnea, central sleep apnea, upper airway resistance syndrome, hypoventilation syndromes and overlap syndrome, and pediatric sleep breathing disorders; sleep bruxism; circadian rhythms disturbances; insomnia; and Willis-Ekbom disease/periodic limb movement disorder. This clinical practice guideline reflects the state of the art at the time of publication and will be reviewed and updated as new information becomes available.

Prevalência de apneia obstrutiva do sono em pacientes que serão submetidos à cirurgia cardíaca internados em uma UTI de alta complexidade / Prevalence of obstructive sleep apnea in patients submitted to heart surgery in a high complexity ICU

Introdução: A apneia obstrutiva do sono (AOS) é caracterizada por obstrução das vias aéreas superiores durante o sono e provoca uma série de consequências para o sistema cardiovascular. Estudos mostram associação de apneia obstrutiva do sono com um mau prognóstico em longo prazo após intervenção coronariana e elevação do índice de infarto agudo do miocárdio. Objetivo: Analisar a prevalência de apneia obstrutiva do sono em pacientes no pré-operátorio de cirurgia cardíaca. Métodos: Estudo transversal no qual foi avaliado prevalência de apneia obstrutiva do sono através do Questionário de Berlin e da Escala de Sonolência de Epworth (ESE). Foram incluídos pacientes no período de julho a outubro de 2017, com idade igual ou superior a 18 anos. Resultados: Foram avaliados 40 pacientes, com idade média de 62,35 ± 7,9 anos e a maioria do sexo masculino (72,5%). O procedimento mais prevalente foi à Cirurgia de Revascularização do Miocárdio (CRM) (80%). Foi identificado alto índice de prevalência de AOS em 62,5% dos participantes; 65% dos pacientes não apresentaram índices significativos de sonolência. Conclusão: Com este estudo vimos que pacientes que realizam cirurgia cardíaca, apresentam alta prevalência de AOS, mas não apresentam necessariamente altos índices de sonolência. Percebe-se que entre os pacientes com maior prevalência de AOS existe uma maior prevalência da realização de Cirurgia de Revascularização do Miocárdio (CRM), mostrando a relação direta de doença cardiovascular com AOS.(AU)

Introduction: Obstructive sleep apnea (OSA) is characterized by obstruction of the upper airways during sleep and causes a number of consequences for the cardiovascular system. Studies show an association of obstructive sleep apnea with a poor long-term prognosis after coronary intervention and elevation of the acute myocardial infarction index. Objective: To analyze the prevalence of OSA in patients in the preoperative period of cardiac surgery. Methods: A cross-sectional study evaluating the prevalence of OSA using the Berlin Questionnaire and the Epworth Sleepiness Scale. Patients were included in the period from July to October 2017, aged 18 years or over. Results: A total of 40 patients were evaluated, with a mean age of 62.35 ± 7.9 years and the majority males (72.5%). The most prevalent procedure was coronary artery bypass grafting (80%). A high prevalence rate of OSA was identified in 62.5% of the participants; 65% of the patients did not present significant drowsiness indexes. Conclusion: With this study, we observed that patients who undergo cardiac surgery have a high prevalence of OSA, but do not necessarily present high rates of sleepiness. Among patients with a higher prevalence of OSA, there is a higher prevalence of coronary artery bypass grafting, showing a direct relationship between cardiovascular disease and OSA. (AU)