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1.
Rev Epidemiol Sante Publique ; 71(4): 101858, 2023 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-37271081

RESUMO

OBJECTIVES: Low back pain (LBP) is one of the main expenditure items for health systems. Data on the economic impact of LBP are uncommon from the patient perspective. The aim of this study was to estimate the economic impact of work disability related to chronic LBP from the patient perspective. METHODS: We conducted a cross-sectional analysis from patients aged over 17 years suffering from non-specific LBP for at least 3 months. Systematic medical, social and economic assessments were collected: pain duration and intensity; functional disability with the Quebec Back Pain Disability Scale (0-100); quality of life with the Dallas Pain Questionnaire; job category; employment status; duration of work disability due to LBP, and income. Factors associated with loss of income were identified by multivariable logistic regression analysis. RESULTS: We included 244 workers (mean age 43 ± 9 years; 36% women); 199 patients had work disability, including 196 who were on sick leave, 106 due to job injury. Three were unemployed due to layoff for incapacity. The mean loss of income for patients with work disability was 14% [SD 24, range -100 to 70] and was significantly less for patients on sick leave due to job injury than on sick leave not related to job injury (p < 0.0001). On multivariable analysis, the probability of loss of income with LBP was about 50% less for overseers and senior managers than workers or employees (odds ratio 0.48 [95% confidence interval 0.23-0.99]). CONCLUSION: Work disability due to LBP resulted in loss of income in our study. The loss of income depended on the type of social protection and job category. It was reduced for patients on sick leave related to work injury and for overseers and senior managers.


Assuntos
Dor Lombar , Humanos , Feminino , Idoso , Adulto , Pessoa de Meia-Idade , Masculino , Dor Lombar/epidemiologia , Dor Lombar/complicações , Qualidade de Vida , Estudos Transversais , Emprego , Quebeque/epidemiologia , Licença Médica
2.
Acta Orthop Belg ; 88(3): 483-489, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-36791701

RESUMO

BACKGROUND: Information is lacking on the natural history of early stages of degenerative rotator cuff disease. Such information can be obtained by using clinical and imaging assessment after conservative treatment in affected patients. HYPOTHESIS: Subacromial impingement syndrome is a clinical presentation that can be associated with early stages of the disease. We aimed to describe the natural history of degenerative rotator cuff disease from the early stages by studying clinical and imaging outcomes in non-operated patients with subacromial impingement syndrome. PATIENTS AND METHODS: Patients with subacromial impingement syndrome were prospectively included. They had conservative treatment and were assessed before treatment and during at least 12-month follow-up. Assessment included clinical evaluation on a 0- to 100-point Constant scale and subscales as well as MRI of the rotator cuff. Clinical results were compared to baseline MRI findings and according to lesional progression. RESULTS: We included 26 patients with mean age 59.1 (SD 9.6), mean pain duration 23.1 (31.3) months; mean total Constant score 39.1 (12.1). Overall, 9 patients had no tear, 9 had a partial tear and 8 had a full-thickness tear. Mean follow-up was 21 (SD 10) months. Total Constant score and subscores improved at follow-up in the overall sample. Patients without tear and those with partial or full-thickness tear at baseline showed clinical improvement. MRI of the rotator cuff at follow-up indicated lesional worsening in 7 patients. However, clinical improvement did not differ by lesional progression or not. CONCLUSION: We report on 21-month clinical and MRI assessments of degenerative rotator cuff disorders including early stages of the disease. Clinical improvement was not related to MRI changes over time. Further investigations are needed to verify our findings in larger study populations.


Assuntos
Lesões do Manguito Rotador , Síndrome de Colisão do Ombro , Humanos , Pessoa de Meia-Idade , Síndrome de Colisão do Ombro/terapia , Síndrome de Colisão do Ombro/tratamento farmacológico , Estudos Prospectivos , Manguito Rotador/cirurgia , Imageamento por Ressonância Magnética , Ruptura , Lesões do Manguito Rotador/diagnóstico por imagem , Lesões do Manguito Rotador/terapia
3.
Skeletal Radiol ; 48(11): 1803-1809, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31114970

RESUMO

OBJECTIVE: The purpose was to evaluate, in a cadaveric cohort, the feasibility and the learning curve of ultrasound-guided percutaneous carpal tunnel release. MATERIALS AND METHODS: Fourteen carpal tunnel releases were carried out on unembalmed cadavers by a senior and a junior radiologist. Procedures were realized with an 18-MHz linear probe. An anatomical evaluation was first performed using ultrasound to detect any anatomical variant. After hydrodissection of the carpal tunnel with lidocaine, a 3-mm hook knife was introduced into the security zone to perform a retrograde section of the transverse carpal ligament (TCL) under ultrasound guidance. Anatomical dissection was performed for each wrist. The main evaluation criterion was the complete TCL section. The procedure duration (minutes), skin incision size (millimeters), the integrity of the median nerve, thenar motor branch, and palmar vascular arch were also evaluated. RESULTS: The senior operator was able to perform a complete release after training on three specimens and the junior operator after four specimens (p > 0.05). In most of the cases when complete release was not achieved, it was due to an incomplete section of the distal TCL (10 mm missing section on average). Mean duration time of procedure was 14 min (11 min for the senior versus 17 min for the junior, p > 0.05). Damage of neither the median nerve nor the vascular structure was observed. Mean size of the skin incision was 3 mm. CONCLUSION: The ultrasound-guided percutaneous release of the carpal tunnel is demonstrated to be a procedure with a rapid learning curve.


Assuntos
Síndrome do Túnel Carpal/diagnóstico por imagem , Síndrome do Túnel Carpal/cirurgia , Competência Clínica/estatística & dados numéricos , Nervo Mediano/diagnóstico por imagem , Nervo Mediano/cirurgia , Radiologistas/estatística & dados numéricos , Ultrassonografia de Intervenção/métodos , Cadáver , Estudos de Viabilidade , Humanos , Curva de Aprendizado , Radiologistas/educação , Radiologistas/normas
4.
Eur Radiol ; 27(11): 4883-4888, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-28593429

RESUMO

INTRODUCTION: Anatomic variations of the median nerve (MN) increase the risk of iatrogenic injury during carpal tunnel release surgery. We investigated whether high-frequency ultrasonography could identify anatomic variations of the MN and its thenar motor branch (MBMN) in the carpal tunnel. METHODS: For each volar wrist of healthy non-embalmed cadavers, the type of MN variant (Lanz classification), course and orientation of the MBMN, and presence of hypertrophic muscles were scored by 18-MHz ultrasound and then by dissection. RESULT: MBMN was identified by ultrasound in all 30 wrists (15 subjects). By dissection, type 1, 2 and 3 variants were found in 84%, 3%, and 13% of wrists, respectively. Ultrasound had good agreement with dissection in identifying the variant type (kappa =0.9). With both techniques, extra-, sub-, and transligamentous courses were recorded in 65%, 31%, and 4% of cases, respectively. With both techniques, the bifid nerve, hypertrophic muscles, and bilateral symmetry for variant type were identified in 13.3%, 13.3%, and 86.7% of wrists, respectively. Agreement between ultrasound and dissection was excellent for the MBMN course and orientation (kappa =1). CONCLUSION: Ultrasound can be used reliably to identify anatomic variations of the MN and MBMN. It could be a useful tool before carpal tunnel release surgery. KEY POINTS: • Ultrasound can identify variations of the motor branch of the median nerve. • Ultrasound mapping should be used prior to carpal tunnel release surgery. • All sub-, extra-, and transligamentous courses were accurately identified. • Type 3 variants (bifid nerve), hypertrophic muscles, and bilateral symmetry were accurately identified.


Assuntos
Nervo Mediano/anatomia & histologia , Nervo Mediano/diagnóstico por imagem , Idoso , Cadáver , Síndrome do Túnel Carpal/diagnóstico por imagem , Síndrome do Túnel Carpal/cirurgia , Dissecação , Feminino , Humanos , Masculino , Ultrassonografia , Punho/diagnóstico por imagem
5.
Eur Radiol ; 25(10): 2969-75, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-25875285

RESUMO

PURPOSE: To study the long-term evolution of the bone marrow burden (BMB) score at MRI in patients with Gaucher disease (GD) under enzyme replacement therapy (ERT). MATERIAL AND METHODS: Forty patients treated for GD were retrospectively studied in a referral centre. BMB scores were assessed on spine and femur MR examinations performed between January 2003 and June 2014. The long-term evolution of the BMB scores was analyzed using a linear mixed model. RESULTS: A total of 121 MRI examinations were performed during the study period with a mean follow-up of 7.1 years ± 5.6, an average rate of 3.1 MR examinations ± 1.7 per patient and an interval of 2.3 years ± 1.1 between examinations. Patients had received ERT during 12 years on average ± 6.7. The trend of BMB scores with time decreased significantly by 15% (P = 0.008) during the total study period and 39% (P = 0.01) during the first 5 years of treatment. No changes in BMB scores were observed after five years of treatment. CONCLUSION: In Gaucher patients, the trend of MRI BMB scores with time decreased significantly under ERT the first 5 years of treatment before a long-term stabilization. KEY POINTS: • Bone marrow infiltration of Gaucher patients responds to enzyme replacement therapy • MRI BMB score decreases mainly during the first five years of treatment • MRI BMB score tends to stabilize after five years of treatment • MR examinations could be limited after five years of treatment.


Assuntos
Doenças da Medula Óssea/etiologia , Terapia de Reposição de Enzimas/métodos , Doença de Gaucher/complicações , Adolescente , Adulto , Idoso , Doenças da Medula Óssea/patologia , Criança , Pré-Escolar , Feminino , Fêmur , Doença de Gaucher/tratamento farmacológico , Doença de Gaucher/patologia , Glucosilceramidase/uso terapêutico , Humanos , Lactente , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Exame Físico/métodos , Encaminhamento e Consulta , Estudos Retrospectivos , Coluna Vertebral , Adulto Jovem
6.
Radiology ; 271(3): 795-804, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-24495266

RESUMO

PURPOSE: To assess the morphologic changes of osteoid osteomas on computed tomographic (CT) scans in association with pain duration. MATERIALS AND METHODS: Institutional review board approval was obtained. Informed consent was waived. From January 2008 to December 2012, 235 patients were treated with interstitial laser ablation at the Hôpital Lariboisière. Ninety-six patients with histopathologically proven osteoid osteomas, complete clinical files, and CT data were studied retrospectively. The following variables were assessed: age, sex, bone location, bone segment, location of the osteoid osteoma in relation to the native cortex, nidus area, nidus calcification area and attenuation at CT, and nidus mineralization ratio (percentage of the calcification area over the total nidus area). Analysis of variance, Kaplan-Meier method, and Cox multivariate regression model were used for statistical analyses. RESULTS: The study sample consisted of 96 patients, 68 of whom were male (71%) and 28 of whom were female (29%) (ratio of male to female patients, 2.4:1). Mean age ± standard deviation was 22.2 years ± 10.4 (range, 4-54 years; median, 18.5 years). The patients' age and nidus mineralization ratio increased significantly with pain duration (hazard ratio, 0.975 [P = .031] and 0.193 [P = .007], respectively). No significant association was found between pain duration and other variables, including the nidus area. In long bones, diaphyseal osteoid osteomas were significantly less mineralized than those in other locations (P = .009). CONCLUSION: The nidus mineralization ratio of osteoid osteomas increases significantly with pain duration and may be a marker of tumor age. Diaphyseal osteoid osteomas demonstrate a lower ratio of nidus mineralization. At the onset of symptoms, older patients experience pain for a longer period before treatment.


Assuntos
Neoplasias Ósseas/diagnóstico por imagem , Osteoma Osteoide/diagnóstico por imagem , Medição da Dor , Dor/patologia , Tomografia Computadorizada por Raios X/métodos , Adolescente , Adulto , Biópsia , Neoplasias Ósseas/patologia , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Osteoma Osteoide/patologia , Estudos Retrospectivos , Fatores de Tempo
7.
Skeletal Radiol ; 42(9): 1323-7, 2013 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-23657611

RESUMO

Intratendinous ganglia are rare. We report the case of a sedentary woman with chronic mechanical anterolateral pain of the knee and an extensive ganglion of the patellar tendon as indicated on magnetic resonance (MR) and ultrasound (US) examinations. There was evidence of a high-riding patella, patellar malalignment and patellar tendon-lateral femoral condyle friction syndrome with significantly close contact between the patellar tendon and the lateral facet of the femoral trochlea. The ultrasound-guided aspiration of the ganglion enabled a localized injection of an anti-inflammatory drug (cortivazol) and the cytopathological examination of the fluid, which confirmed the diagnosis. Clinical improvement was maintained with knee rehabilitation and was satisfactory at follow-up after 1 year. To our knowledge, we report the first case of a ganglion of the patellar tendon subsequent to patellar tendon-lateral femoral condyle friction syndrome. We found that this case was illustrative of mucoid degeneration in connective tissue due to chronic repetitive microtraumas. Additionally, this case provided the opportunity to discuss the management of this condition in a sedentary individual with a high-riding patella and patellar malalignment.


Assuntos
Imageamento por Ressonância Magnética/métodos , Síndrome da Dor Patelofemoral/diagnóstico , Síndrome da Dor Patelofemoral/etiologia , Tendinopatia/complicações , Tendinopatia/diagnóstico , Ultrassonografia/métodos , Adulto , Diagnóstico Diferencial , Feminino , Cistos Glanglionares , Humanos , Ligamento Patelar/diagnóstico por imagem , Ligamento Patelar/patologia
8.
World J Nucl Med ; 22(1): 15-21, 2023 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-36923983

RESUMO

Objective Amyloid positron emission tomography (PET) plays a vital role in the in vivo detection of ß-amyloid accumulation in Alzheimer's disease. Increasingly, trainees and infrequent readers are relying on semiquantitative analyses to support clinical diagnostic efforts. Our objective was to determine if the visual assessment of amyloid PET may be facilitated by relying on semiquantitative analysis. Methods We conducted a retrospective review of [ 18 F]-florbetaben PET/computed tomographies (CTs) from 2016 to 2018. Visual interpretation to determine Aß+ status was conducted by two readers blinded to each other's interpretation. Scans were then post-processed utilizing the MIMneuro software, which generated regional-based semiquantitative Z-scores indicating cortical Aß-burden. Results Of 167 [ 18 F]-florbetaben PET/CTs, 92/167 (reader-1) and 101/167 (reader-2) were positive for amyloid deposition (agreement = 92.2%, κ = 0.84). Additional nine scans were identified as possible Aß-positive based solely on semiquantitative analyses. Largest semiquantitative differences were identified in the left frontal lobe (Z = 7.74 in Aß + ; 0.50 in Aß - ). All unilateral regions showed large statistically significant differences in Aß-burden ( P ≤ 2.08E-28). Semiquantitative scores were highly sensitive to Aß+ status and accurate in their ability to identify amyloid positivity, defined as a positive scan by both readers (AUC ≥ 0.90 [0.79-1.00]). Spread analyses suggested that amyloid deposition was most severe in the left posterior cingulate gyrus. The largest differences between Aß +/Aß- were in the left frontal lobe. Analyses using region-specific cutoffs indicated that the presence of amyloid in the temporal and anterior cingulate cortex, while exhibiting relatively low Z-scores, was most common. Conclusion Visual assessment and semiquantitative analysis provide highly congruent results, thereby enhancing reader confidence and improving scan interpretation. This is particularly relevant, given recent advances in amyloid-targeting disease-modifying therapeutics.

9.
J Psychosom Res ; 173: 111469, 2023 10.
Artigo em Inglês | MEDLINE | ID: mdl-37639884

RESUMO

OBJECTIVE: Little is known about the longitudinal relationship between carpal tunnel syndrome (CTS) and mental health. Therefore, this retrospective cohort study investigated the association between CTS and the five-year incidence of anxiety disorder and depression in adults from Germany. METHODS: Data from the Disease Analyzer database (IQVIA) were used for the present study. Patients aged ≥18 years diagnosed for the first time with CTS in one of 1284 general practices in Germany in 2005-2020 were included (index date). Individuals without CTS were matched to those with CTS using a propensity score based on age, sex, the mean number of consultations per year during the follow-up, and the index year. In people without CTS, the index date was a randomly selected consultation in 2005-2020. RESULTS: There were 75,135 patients with and 75,135 patients without CTS included in the study (mean [SD] age 57.2 [16.5] years; 59.7% women). Within five years of the index date, the incidence of anxiety disorder was 3.9% and 3.6% in the group with and the group without CTS, respectively (log-rank p-value<0.001), while figures for depression were 14.8% and 11.5% (log-rank p-value<0.001). These findings were corroborated in the Cox regression analyses adjusted for multiple physical conditions, as CTS was associated with anxiety disorder (HR = 1.14, 95% CI = 1.08-1.21) and depression (HR = 1.29, 95% CI = 1.25-1.33) in the overall sample. CONCLUSION: CTS was associated with an increased incidence of anxiety disorder and depression in Germany. Further research should identify the mediators involved in these relationships.


Assuntos
Síndrome do Túnel Carpal , Adolescente , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Transtornos de Ansiedade/epidemiologia , Síndrome do Túnel Carpal/epidemiologia , Síndrome do Túnel Carpal/psicologia , Depressão/etiologia , Alemanha/epidemiologia , Incidência , Estudos Retrospectivos , Idoso
10.
J Back Musculoskelet Rehabil ; 35(5): 1119-1124, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35342077

RESUMO

BACKGROUND: Dynamic humeral centering (DHC) is a physiotherapy modality that aims to prevent sub-acromial impingement of rotator cuff tendons. We recently developed a new clinical manoeuver - the Viggo-Cochin test - to enhance the ability of the Neer test to detect sub-acromial impingement. Here we hypothesised whether the DHC effect may differ between individuals with positive and negative Viggo-Cochin test results. OBJECTIVE: To assess the association between DHC and Viggo-Cochin test results. METHODS: Individuals with shoulder pain due to sub-acromial impingement underwent the Neer and Viggo-Cochin tests at baseline. They were assessed before and after DHC by the Shoulder Pain and Disability Index (SPADI). A positive response to DHC was defined as a 20% reduction in the SPADI. RESULTS: We included 50 individuals (53 shoulders). The response to DHC did not differ by Neer test result at baseline: OR 0.73 [95% CI 0.22-2.38] (p= 0.601). By contrast, the response to DHC was 5-fold higher with a positive than negative Viggo-Cochin test result: OR 5.11 [95% CI 1.47-17.78] (p= 0.010). CONCLUSIONS: We found a higher clinical response to DHC with a positive than negative Viggo-Cochin test result at baseline in individuals with shoulder pain due to rotator cuff disease.


Assuntos
Lesões do Manguito Rotador , Síndrome de Colisão do Ombro , Acrômio , Humanos , Úmero , Modalidades de Fisioterapia , Síndrome de Colisão do Ombro/diagnóstico , Dor de Ombro/diagnóstico , Dor de Ombro/terapia
11.
Orthop Traumatol Surg Res ; 108(3): 103255, 2022 05.
Artigo em Inglês | MEDLINE | ID: mdl-35183755

RESUMO

INTRODUCTION: Abnormal biceps femoris distal tendon insertion can cause tendon snapping, as is well-known in the literature. The presenting symptom is lateral knee pain, often during sports activities and cycling in particular. The present study tested two hypotheses: abnormal biceps femoris insertion on the fibular head may cause painful friction without clinical snapping, whether visible, audible or palpable; surgical correction achieves good results for pain and return to sport, regarding both snapping and friction. MATERIAL AND METHODS: Between 2006 and 2017, 11 patients were managed for pain secondary to abnormal biceps femoris insertion. In 4 cases, pain was bilateral, resulting in a total of 15 knees: 9 with snapping (in 6 patients), and 6 with friction syndrome without snapping (in 5 patients). All 6 patients with snapping were male, with a mean age of 29 years. Friction without snapping concerned 3 female and 2 male patients, with a mean age of 30 years. Study data included type and level of sport, clinical signs, imaging, type and results of treatment, and type of abnormality. RESULTS: The insertion abnormality consisted in excessively anterior insertion in the fibular arm in 6 cases, in predominantly tibial insertion in 2 cases, and in isolated tibial insertion in 4 cases. Surgery mainly consisted inrelease and reinsertion of the distal biceps femoris tendon (in 7 cases). All patients were able to return to sport. The mechanism underlying snapping and friction was the same: distal biceps tendon friction on the fibular head secondary to unduly anterior fibular or predominantly or exclusively tibial insertion. DISCUSSION: The literature reports 24 cases, all of snapping, with between 1 and 3 cases per author. These findings were compared with the present results. With or without snap, symptoms are secondary to abnormal tendon insertion and to activity or sport requiring repeated knee flexion greater than 90°. CONCLUSIONS: (1) Case studies show that lateral knee pain by friction on the fibular head is not systematically accompanied by snapping. (2) In all reports and in the present series, surgery was highly effective on snapping and pain, and patients returned to sport at their previous level. LEVEL OF EVIDENCE: IV.


Assuntos
Músculos Isquiossurais , Adulto , Feminino , Fíbula/cirurgia , Fricção , Humanos , Masculino , Dor/etiologia , Tendões/cirurgia
12.
Clin Imaging ; 90: 63-70, 2022 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-35926315

RESUMO

INTRODUCTION: Cerebral Venous Thrombosis (CVT), prior to the COVID pandemic, was rare representing 0.5 of all strokes, with the diagnosis made by MRI or CT venography.1-,3 COVID-19 patients compared to general populations have a 30-60 times greater risk of CVT compared to non-affected populations, and up to a third of severe COVID patients may have thrombotic complications.4-8 Currently, vaccines are the best way to prevent severe COVID-19. In February 2021, reports of CVT and Vaccine-induced immune thrombotic thrombocytopenia (VITT) related to adenovirus viral vector vaccines including the Oxford-AstraZeneca vaccine (AZD1222 (ChAdOx1)) and Johnson & Johnson COVID-19 vaccine (JNJ-78436735 (Ad26.COV2·S)), were noted, with a 1/583,000 incidence from Johnson and Johnson vaccine in the United States.11, 12 This study retrospectively analyzed CVT and cross-sectional venography at an Eastern Medical Center from 2018 to 2021, and presents radiographic examples of CVT and what is learned from the immune response. METHODS: After IRB approval, a retrospective review of cross-sectional CTV and MRVs from January 1st 2018 to April 30th 2021, at a single health system was performed. Indications, vaccine status, patient age, sex, and positive finding incidence were specifically assessed during March and April for each year. A multivariable-adjusted trends analysis using Poisson regression estimated venogram frequencies and multivariable logistic regression compared sex, age, indications and vaccination status. RESULTS AND DISCUSSION: From January 1, 2018 to April 30, 2021, (Fig. 1), a total of n = 2206 in patient and emergency room cross-sectional venograms were obtained, with 322 CTVs and 1884 MRVs. In 2018, 2019, 2020, respective totals of cross-sectional venograms were 568, 657, 660, compared to 321 cross-sectional venograms in the first four months of 2021. CTV in 2018, 2019, 2020, respective totals were 51, 86, 97, MRV totals were 517, 571, 563, compared to the 2021 first four month totals of 88 CTVs and 233 MRVs. March, April 2018, 2019, 2020, CTVs respectively were 6, 17, 11, compared to the 2021 first four months of 59 CTVs, comprising 63% of the total 93 CTVs, respective MRVs were 79, 97, 52, compared to 143 MRVs in the first four months of 2021 for 39% of the total 371 MRVs. In March, April 2020 during the pandemic onset, cross-sectional imaging at the East Coast Medical Center decreased, as priorities were on maintaining patient ventilation, high level of care and limiting spread of disease. In March/April 2021, reports of VITT and CVT likely contributed to increased CTVs and MRVs, of 39.65% [1.20-1.63] increase (P < 0.001) from prior. In March, April 2021 of 202 venograms obtained, 158 (78.2.%) were unvaccinated patients, 16 positive for CVT (10.1%), 44 were on vaccinated patients (21.7%), 8 specifically ordered with vaccination as a clinical indication, 2 positive for CVT (4.5%), (odds ratio = 0.52 [0.12-2.38], p = 0.200). CONCLUSION: CTV prior to the COVID pandemic, was rare, responsible for 0.5 of all strokes, at the onset of the pandemic in the East Coast, overall cross-sectional imaging volumes declined due to maintaining ventilation, high levels of care and limiting disease spread, although COVID-19 patients have a 30-60 times greater risk of CVT compared to the general population, and vaccination is currently the best option to mitigate severe disease. In early 2021, reports of adenoviral vector COVID vaccines causing CTV and VITT, led to at 39.65% increase in cross-sectional venography, however, in this study unvaccinated patients in 2021 had higher incidence of CVT (10.1%), compared to the vaccinated patients (4.5%). Clinicians should be aware that VITT CVT may present with a headache 5-30 days post-vaccination with thrombosis best diagnosed on CTV or MRV. If thrombosis is present with thrombocytopenia, platelets <150 × 109, elevated D-Dimer >4000 FEU, and positive anti-PF4 ELISA assay, the diagnosis is definitive.13 VITT CVT resembles spontaneous autoimmune heparin induced thrombocytopenia (HIT), and is postulated to occur from platelet factor 4 (PF4) binding to vaccine adenoviral vectors forming a novel antigen, anti-PF4 memory B-cells and anti-PF4 (VITT) antibodies.14-17.


Assuntos
Vacinas contra COVID-19 , COVID-19 , Trombose Intracraniana , Trombocitopenia , Trombose Venosa , Ad26COVS1 , COVID-19/prevenção & controle , Vacinas contra COVID-19/efeitos adversos , ChAdOx1 nCoV-19 , Humanos , Imunidade , Trombose Intracraniana/induzido quimicamente , Trombose Intracraniana/imunologia , Estudos Retrospectivos , Trombocitopenia/induzido quimicamente , Trombocitopenia/imunologia , Trombose Venosa/induzido quimicamente , Trombose Venosa/imunologia
13.
Eur Radiol ; 20(1): 181-9, 2010 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-19680658

RESUMO

BACKGROUND: Selective steroid injections of the lumbar spine carry a risk of paraplegia of sudden onset. Seven cases have been reported in the English literature since 2002. MATERIALS AND METHODS: Five new cases have been analyzed, all coming from Paris area centers. Injections were performed between 2003 and 2008. The following items were searched for: location of a previous lumbar spine surgery if any, symptoms indicating the procedure, route of injection, imaging technique used for needle guidance, injection of a contrast medium, type of steroid, other drugs injected if any, paraplegia level, post-procedure MR findings. The current and reported cases were compared. RESULTS: MR findings were consistent with spinal cord ischemia of arterial origin. The high rate of patients who had been operated on in these cases does not correspond to that of patients undergoing injections. The presence of epidural scar might increase the risk. The foraminal route was the only one involved in nonoperated patients. Foraminal, interlaminar, or juxta-zygoapophyseal routes were used in operated-on patients. CONCLUSION: The high rate of French cases when compared to the literature might arise from the almost exclusive use of prednisolone acetate, a molecule with a high tendency to coalesce in macro-aggregates, putting the spinal cord at risk of arterial supply embolization.


Assuntos
Injeções Espinhais/efeitos adversos , Vértebras Lombares , Paraplegia/diagnóstico , Paraplegia/etiologia , Esteroides/administração & dosagem , Esteroides/efeitos adversos , Adulto , Idoso , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade
14.
Arthroscopy ; 26(3): 302-9, 2010 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-20206038

RESUMO

PURPOSE: The aim of this study was to assess tendon healing and clinical results of rotator cuff tears (RCTs) repaired arthroscopically in patients aged 65 years or older. METHODS: Between January 2001 and December 2004, 88 patients with a mean age of 70 years (range, 65 to 85 years) had arthroscopic RCT repair. The repair was performed on 54 women (61%). The dominant arm was involved in 72 patients (82%). RCT included more than 2 tendons in 45 cases. Functional outcomes were assessed by use of the Constant score and Simple Shoulder Test. Tendon healing was estimated by use of a computed tomography (CT) arthrogram, which was obtained 6 months postoperatively, and was classified into 3 categories: stage 1, watertight and anatomic healing; stage 2, watertight and partial healing; and stage 3, not watertight and retear. RESULTS: The mean duration of follow-up was 41 months (range, 24 to 77 months). The mean clinical outcome scores all improved significantly at the time of the final follow-up (P < .01). Computed tomography arthrogram imaging showed 27 shoulders with a stage 1 repair, 20 with a stage 2 repair, and 34 with a stage 3 repair. The retear rate was 42% (34 of 81). The patients with tendon healing stage 1 or 2 had a significantly superior functional outcome in terms of overall scores and strength compared with the stage 3 repairs (P < .01). In our study we had 39 isolated supraspinatus tears (small or medium tears); 11 (28.9%) had a retear (stage 3). CONCLUSIONS: Arthroscopic repair in patients aged 65 years or older can yield tendon healing resulting in significant functional improvement. Our data suggest that arthroscopic repair can be considered successful for the older patient specifically when the tear is limited to the supraspinatus tendon. LEVEL OF EVIDENCE: Level IV, therapeutic case series.


Assuntos
Artroscopia/métodos , Lesões do Manguito Rotador , Manguito Rotador/cirurgia , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Distribuição de Qui-Quadrado , Feminino , Seguimentos , Humanos , Modelos Logísticos , Masculino , Recuperação de Função Fisiológica , Manguito Rotador/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Cicatrização/fisiologia
15.
Arthroscopy ; 24(1): 25-33, 2008 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-18182198

RESUMO

PURPOSE: We investigated how soon postoperative functional recovery became significant after arthroscopic rotator cuff repair and the influence of tendon healing. METHODS: We conducted a prospective study on 114 cases of full-thickness rotator cuff tears arthroscopically repaired from January 2001 to December 2003. All patients were evaluated by the Constant scoring system at 3, 6, 12, and 24 months after surgery and at last follow-up. Computed tomography arthrography was done at 6 months postoperatively to study the progression of tendon healing. RESULTS: The Constant score significantly improved from the third month after surgery (P < .0001) until the twelfth month, after which it stabilized (P < .0001). At last follow-up (31 months), the mean score was 80.1 points (range, 50 to 95 points). Female sex (P < .0001), upper-limb heavy work (P < .0001), poor bone quality (P = .039), and absence of healing (P = .002) were negative predictive factors. In particular, the absence of tendon healing leads to a worsening of the results from the twelfth month onward. CONCLUSIONS: Arthroscopic repair of rotator cuff lesions as performed in this study gives very good results in terms of functional recovery. Our study showed functional recovery as early as 3 months after surgery and further improvement over the first year, followed by stabilization. We found that female sex, upper-limb heavy work, poor bone quality, and lack of tendon healing were all negatively associated with outcome. Patients presenting with a retear differed from the other patients, in that their clinical progression showed a significant rise in the Constant score over the first year, with a lowering of the score thereafter. LEVEL OF EVIDENCE: Level IV, therapeutic case series.


Assuntos
Artrografia , Artroscopia , Manguito Rotador/diagnóstico por imagem , Traumatismos dos Tendões/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Cicatrização , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Recuperação de Função Fisiológica , Manguito Rotador/cirurgia , Traumatismos dos Tendões/cirurgia , Fatores de Tempo
16.
Rev Prat ; 58(3): 273-8, 2008 Feb 15.
Artigo em Francês | MEDLINE | ID: mdl-18536201

RESUMO

Non-specific low-back pain (LBP) should de differentiated from symptomatic LBP, attributed to recognisable, known specific pathology (e.g. tumour, infection, inflammatory disease...). The initial clinical history taking should aim at identifying "red flags", associated with a higher risk of serious disorders. Rapid MRI of the spine should be performed in order to make a specific diagnosis. In chronic LBP, X-rays of the spine are always performed, first to rule out underlying specific diagnosis, then to describe degenerative spine changes. At MRI and X-rays, most of degenerative disc abnormalities are non-specific, frequently found in the asymptomatic subjects. On fat-suppressed T2WI, edema of endplates in degenerative disc disease and of posterior arches in facet arthropathy and spondylolysis is well-correlated to LBP. Such edema may be useful to guide the treatment.


Assuntos
Dor Lombar/diagnóstico , Doença Crônica , Humanos , Dor Lombar/patologia , Imageamento por Ressonância Magnética
17.
Joint Bone Spine ; 85(5): 545-552, 2018 10.
Artigo em Inglês | MEDLINE | ID: mdl-29154980

RESUMO

Carpal tunnel syndrome is the most common nerve entrapment syndrome. The majority of cases are due to compression or irritation of the median nerve in the carpal canal. It is diagnosed clinically, often being confirmed by an electromyogram, while ultrasonography criteria have become increasingly useful for the diagnosis. Ultrasonography is better tolerated, less expensive, yet just as effective as other diagnostic methods. It provides a good indication of the severity of the condition and it allows anatomical variants to be discerned. In light of this, for a number of medical professionals it is the first-line examination. In terms of therapeutic use, ultrasound can be used to guide infiltrations. In case medical treatment is unsuccessful, release by transection of the flexor retinaculum is generally done surgically as an open procedure or by endoscopy. A new minimally invasive percutaneous treatment to release the nerve based on ultrasonography guided or ultrasound surgery appears to be a promising alternative, however, to conventional open surgery or endoscopic treatments.


Assuntos
Síndrome do Túnel Carpal/diagnóstico por imagem , Síndrome do Túnel Carpal/cirurgia , Descompressão Cirúrgica/métodos , Cirurgia Assistida por Computador/métodos , Síndrome do Túnel Carpal/fisiopatologia , Eletromiografia/métodos , Feminino , Humanos , Masculino , Prognóstico , Recuperação de Função Fisiológica , Índice de Gravidade de Doença , Resultado do Tratamento , Ultrassonografia de Intervenção
18.
Semin Intervent Radiol ; 35(4): 248-254, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30402007

RESUMO

Carpal tunnel syndrome (CTS) may be treated surgically if medical treatment fails. The classical approach involves release of the flexor retinaculum by endoscopic or open surgery. Meta-analyses have shown that the risk of nerve injury may be higher with endoscopic treatment. The recent contribution of ultrasound to the diagnosis and therapeutic management of CTS opens new perspectives. Ultrasound-guided carpal tunnel release via a minimally invasive approach enables the whole operation to be performed as a percutaneous radiological procedure. The advantages are a smaller incision compared with classical techniques; great safety during the procedure by visualization of anatomic structures, particularly variations in the median nerve; and realization of the procedure under local anesthesia. These advantages lead to a reduction in postsurgical sequelae and more rapid resumption of daily activities and work. Dressings are removed by the third day postsurgery. Recent studies seem to confirm the medical, economic, and aesthetic benefits of this new approach.

19.
Ann Phys Rehabil Med ; 61(3): 151-155, 2018 May.
Artigo em Inglês | MEDLINE | ID: mdl-29452331

RESUMO

BACKGROUND: The Neer, Hawkins, and Yocum clinical tests detect sub-acromial impingement as a pathogenic process of degenerative rotator cuff disease. Their reproducibility has been little investigated. OBJECTIVES: We tested the reproducibility of the Neer, Hawkins, and Yocum clinical tests for detecting this sub-acromial impingement and also an original clinical manoeuver, the countertest with elevation with lateral rotation (CELR), which is a test of sub-acromial impingement. METHODS: Patients with shoulder pain due to degenerative rotator cuff disease were prospectively included. They were assessed with the Neer, Hawkins and Yocum tests as well as the CELR twice at a 1 week interval. Intra- and inter-observer reproducibility was assessed by percentage agreement and the kappa coefficient of concordance with 95% confidence intervals (CIs). Concordance was poor with kappa ≤0.4, moderate >0.4, and good >0.61. It was considered suitable for clinical use with kappa >0.4. RESULTS: We included 34 patients (mean [SD] age 60 [11] years; 26 females). For intra-observer reproducibility, agreement was 80% to 88%. By the kappa coefficient, intra-observer reproducibility was poor for the Neer test and moderate for the Hawkins test (0.56 [95% CI 0;0.9]) and Yocum test (0.48 [0;0.8]) and CELR (0.6 [0.2;0.9]). For inter-observer reproducibility, agreement was 73% to 88%. By the kappa coefficient, inter-observer reproducibility was poor for the Yocum test, moderate for the Hawkins test (0.54 [0.2;0.8]) and CELR (0.58 [0.2;0.8]), and good for the Neer test (0.64 [0.2;0.9]). CONCLUSION: The Hawkins test and CELR had a balanced profile of reproducibility suitable for clinical practice. We underline the potential interest of CELR, an original manoeuver.


Assuntos
Exame Físico , Lesões do Manguito Rotador/diagnóstico , Manguito Rotador/fisiopatologia , Dor de Ombro/diagnóstico , Idoso , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Reprodutibilidade dos Testes , Lesões do Manguito Rotador/fisiopatologia , Dor de Ombro/fisiopatologia
20.
Am J Sports Med ; 35(8): 1247-53, 2007 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-17452513

RESUMO

BACKGROUND: Increasing the rate of watertight tendon healing has been suggested as an important criterion for optimizing clinical results in rotator cuff arthroscopic repair. HYPOTHESIS: A double-row anchorage technique for rotator cuff repair will produce better clinical results and a better rate of tendon healing than a single-row technique. STUDY DESIGN: Cohort study; Level of evidence, 2. METHODS: We compared 31 patients undergoing surgery with a double-row anchorage technique using Panalok anchors and Cuff Tack anchors and 35 patients with rotator cuff tear undergoing surgery with a single-row anchorage arthroscopic technique using Panalok anchors. We compared pre- and postoperative Constant score and tendon healing, as evaluated by computed tomographic arthrography 6 months after surgery, in these 2 groups. RESULTS: The Constant score increased significantly in both groups, with no difference between the 2 groups (P = .4). Rotator cuff healing was judged anatomic in 19 patients with double-row anchorage and in 14 patients with single-row anchorage; this difference between the groups was significant (P = .03). CONCLUSION: In this first study comparing double- and single-row anchorage techniques, we found no significant difference in clinical results, but tendon healing rates were better with the double-row anchorage. Improvements in the double-row technique might lead to better clinical and tendon healing results.


Assuntos
Artrografia , Artroscopia/normas , Lesões do Manguito Rotador , Manguito Rotador/cirurgia , Âncoras de Sutura , Técnicas de Sutura/normas , Traumatismos dos Tendões/cirurgia , Tomografia Computadorizada por Raios X , Cicatrização , Adulto , Estudos de Coortes , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos
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