Detalhe da pesquisa
1.
SARS-CoV-2 nsp15 endoribonuclease antagonizes dsRNA-induced antiviral signaling.
Proc Natl Acad Sci U S A
; 121(15): e2320194121, 2024 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38568967
2.
SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in cell culture and in mice.
Proc Natl Acad Sci U S A
; 120(35): e2302083120, 2023 08 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-37607224
3.
PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell- and tissue-specific manner.
J Virol
; 97(9): e0088523, 2023 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37695054
4.
Discovery of 2-Amide-3-methylester Thiophenes that Target SARS-CoV-2 Mac1 and Repress Coronavirus Replication, Validating Mac1 as an Antiviral Target.
J Med Chem
; 67(8): 6519-6536, 2024 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38592023
5.
Mutation of highly conserved residues in loop 2 of the coronavirus macrodomain demonstrates that enhanced ADP-ribose binding is detrimental to infection.
bioRxiv
; 2024 Jan 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38260573
6.
PARP14 is pro- and anti-viral host factor that promotes IFN production and affects the replication of multiple viruses.
bioRxiv
; 2024 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38712082
7.
SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in mice.
bioRxiv
; 2023 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37066301
8.
SARS-CoV-2 nsp15 endoribonuclease antagonizes dsRNA-induced antiviral signaling.
bioRxiv
; 2023 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38014074
9.
Discovery of 2-amide-3-methylester thiophenes that target SARS-CoV-2 Mac1 and repress coronavirus replication, validating Mac1 as an anti-viral target.
bioRxiv
; 2023 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38234730