[Problem of false positives in dipyridamole-echocardiography test. Description of a case and review of the literature]. / Il problema dei falsi positivi nel test eco-dipiridamolo. Descrizione di un caso e revisione della letteratura.

Dipyridamole-echocardiography may be considered, at this time, an useful test not only in post-infarction risk stratification, but also in diagnosis and functional evaluation of coronary artery disease, having a satisfying sensibility (67%) and a very high specificity (96%). We report a particular case of "false positive" with a review of the literature. The patient, male, aged 45, without important risk factors for coronary artery disease, experimented recurrent events of spontaneous chest pain, typical per angina pectoris. Physical examination, chest roentgenogram and blood samples were normal. Slight signs of subendocardial ischemia, lateral, were present at ECG. Forced hyperpnea resulted in onset of chest pain, with increase of ECgraphic signs of ischemia; resolution of both was obtained with sublingual nitrate administration. A stress test with myocardial flow scintigraphic assessment using sestaMIBI, was performed: ECG showed significant ST downsloping at low workload (1-11 steps of Bruce protocol) and radionuclide tomography showed reversible hypoperfusion in anterior and septal regions. High dose dipyridamole-echocardiography test (a first bolus of 0.56 mg/kg in 4', followed after 4' by a second bolus of 0.28 mg/kg) gave these results: basal echocardiogram was normal; after first bolus of dipyridamole apical hypokinesia appeared; after second bolus complete akinesia was observed. ECG showed subendocardial injury wave and the patient experimented typical anginal pain. Clinical, electrocardiographic and echocardiographic changes were immediately reversed after intravenous bolus of aminophylline, 240 mgs. Coronary arteriography was performed: coronary arteries were angiographically normal, without even any marginal irregularity: left ventricle was normal in volume, wall kinesis and ejection fraction. Dipyridamole is a powerful ischemic stressor.(ABSTRACT TRUNCATED AT 250 WORDS)

[Calcitonin-induced anaphylactic shock. Case report and review of the literature]. / Shock anafilattico da calcitonina. Descrizione di un caso e revisione della letteratura.

A case of anaphylactic shock determined by intramuscular administration of a dose of synthetic calcitonin in a 64-years-old man is described. The patient had not suffered significant cardiovascular events in the past; he smoked twenty cigarettes a day and he was treated with calcitonin for osteoporosis and polyarthrosis. Allergy to diclofenac was demonstrated in the past while preceding administrations of spray calcification didn't provoke side-effects in the patient. Nevertheless after the second i.m. administration of the drug he suddenly fainted. Dyspnea, severe hypotension and maculo-papular erythema were present at the moment of admission to our hospital. The continuous electrocardiogram monitoring showed a characteristic "migrant" ST elevation at first in the anterior leads, then in inferior and septal leads, and premature ventricular and atrial beats. The echocardiographic transtoracic examination proved an apical and septal akinesia which completely disappeared after one hour at a second echocardiographic examination. In spite of intensive medical treatment (lignocaine and hydrocortisone e.v.) the patient had a sustained ventricular tachycardia that quickly degenerated into ventricular fibrillation. After one DC shock at 300 joules we observed spontaneous spontaneous restoration of the normal sinus rhythm. The following clinical evolution was good and no other arrhythmias or cardiovascular symptoms were observed. In order to estimate the reasons of the clinical picture the patient was submitted to serial blood examinations, serial electrocardiograms, exercise stress test, echodypiridamole stress test and serial echocardiograms. The blood examinations showed a relative eosynophilia (3%), the increase of IgE serum level (316 UI) and transient ipokalemia (2.3 mEq/l). None pathological findings were observed in the other examinations.(ABSTRACT TRUNCATED AT 250 WORDS)

[Pseudoaneurysm and aneurysm of the left ventricle. Discription of a case and long-term follow-up]. / Pseudoaneurisma e aneurisma del ventricolo sinistro. Descrizione di un caso e follow-up a lungo termine.

UNLABELLED: Left ventricle pseudoaneurysm is an uncommon complication of myocardial infarction; urgent operation is usually recommended, because of the high rate of severe complications. We report a single case with coexistence of a true aneurysm and a pseudoaneurysm, asymptomatic after three years of follow up in the absence of surgery. CASE REPORT: The patient, female, aged 69, was observed after an event of prolonged chest pain; ECG showed inferolateral necrosis. Echocardiographic examination showed: left ventricle enlargement with postero-lateral akinesis and septo-apical aneurysm, thin apical thrombosis and mild mitral regurgitation; a non-contractile concameration, aside of lateral wall, containing some thrombotic material and communicating with the left ventricle through a little hole (gap of echoes), crossed by a very little inflow jet. The diagnosis of coexisting septo-apical "true" aneurysm and postero-lateral pseudoaneurysm was confirmed with CT scan, NMR and left ventriculography. Coronary angiography showed total occlusion of LAD and a critical stenosis of mid LAD. The patient refused the operation. In 36 months follow-up no symptoms nor significant echocardiographic changes were observed. DISCUSSION: The pseudoaneurysm is caused by slow fissuration of the myocardium (after a myocardial infarction) with adhesion of pericardium and fibrosis, resulting in a saccular cavity, communicating with the left ventricle by a little hole; on the contrary the more frequent "true" aneurysm is a progressive dilatation and thinning of the ventricular wall, with parietal fibrotic degeneration. Echocardiography may be useful in differential diagnosis, but an excellent quality of the images is required and false negatives and positives are frequent. In this case the echocardiographic features include the thickness of the pseudoaneurysmal wall, the very low flow through the communication hole and the minimal mitralic involvement. CONCLUSION: This particular pattern, when accurately assessed, could probably be predictive of low risk and favorable prognosis in patients with pseudoaneurysm.

[Pulmonary thromboembolism. A clinical case with unusual presentation]. / Malattia tromboembolica polmonare. Descrizione di un caso clinico a presentazione insolita.

The authors describe a rare case of pulmonary thromboembolism with unusual clinical findings and emphasized the large difficulty encountered in formuling a correct diagnosis in a reasonable time. A man, 60 years old, was admitted to a Medical Division of our hospital for the appearance of chest pain and epigastric pain during effort in the last year. He smoked 20 cigarettes a day and drank wine (1 or 2 litres a day). He was affected by hypercholesterolemia and in the past reported relapsed thrombophlebitis in the left leg. Four years before admission to our hospital he underwent large and small left saphenectomy. He had no cardiac events in the past. After a non significant exercise stress test the patient was treated with nitrates and asa and was discharged from the hospital. At home the symptoms increased and after 8 months the patient was admitted again to the Cardiologic Division of the hospital. At admission he reported dyspnea and chest pain at rest, not only during effort and the ECG showed negative T waves in anterior and inferior leads. Intravenous heparine, nitrates and calcium antagonists stabilized the clinical picture. The following examinations revealed: reduction of the T wave negativity at the ECG registered during chest pain; mild enlargement of the heart at the chest roentgenogram; normal value of the left ventricle and apical and midseptal by ipokinesia at the transthoracic echocardiogram; normal coronary artery at the coronary arteriography. "Vasospastic angina" was diagnosed and the patient was discharged after 20 days, asymptomatic. After 15 days he returned to the hospital again for chest pain, dyspnea, hypotension and syncope despite therapy. At physical examination he showed a painful left tibio-tarsal tumefaction, an increased and splitting second heart sound in the pulmonary area and a systolic murmur in the third and fourth left interspace. The ECG showed a severe anterior ischemia, while a new transthoracic echocardiogram revealed a considerable dilatation of the right atrium, right ventricle and the main pulmonary artery with severe tricuspid regurgitation and pulmonary hypertension (mean PAP about 50 mmHg). The following pulmonary perfusion scintigraphy confirmed the diagnosis of pulmonary embolism and the selective right and left pulmonary arteriography exhibited multiple thrombi and large intravascular filling defects. The right heart catheterization confirmed a chronic precapillary pulmonary hypertension (mean PAP = 55 mmHg). About 24 hours after these examinations the patient died because of a cardiac arrest with electromechanical dissociation. Pulmonary thromboembolism is a potentially fatal disease characterized by a largely variable clinical presentation. Frequently pulmonary embolism diagnosis is difficult especially when clinical findings are unusual. In the case observed the "typical" chest and epigastric pains associated with the electrocardiographic findings directed diagnosis towards myocardial ischemia. Also after the coronary arteriography that showed normal coronary artery, the erroneous diagnosis persisted. Pulmonary embolism was correctly diagnosed too late to begin an effective therapy. These unusual clinical findings and diagnostic mistakes are stressed and critically reviewed in the article.

[An unusual case of "catecholamine necrosis" caused by accidental digitalis poisoning]. / Un raro caso di "necrosi catecolaminica" da intossicazione digitalica accidentale.

Toxic manifestations of digitalis are one of the most prevalent adverse drug reactions encountered in clinical practice. The estimated incidence is about 20% in hospitalized patients in the USA. The authors describe a rare case of myocardial "catecholamine necrosis" (anteroseptal myocardial infarction) during accidental digitalis intoxication. A male patient, 75 years old, suffering from cirrhosis and ascites, take on by mistake a tablet of digoxin 0.25 mg. four times at day for eleven days. He hadn't heart disease in the past. At the eleventh day the patient showed a deep tiredness and so he was submitted to a clinical examination and electrocardiogram. The ECG demonstrated an anteroseptal myocardial infarction in the second-third electrical stage. The patient was hospitalized. The successive examination revealed: very high plasma digitalis concentrations; an increase of the serum levels of CPK and LDH; a significant increase of plasmatic and urinary catecholamine levels which return to normal values after fifteen days; apical akinesia at the echocardiographic examination; no signs of residual myocardial ischemia to the echo-dypiridamole stress test; normal coronary artery to the coronary arteriography and absence of coronary artery spasm to the ergonovine test. Furthermore the abdominal echography and the abdominal computerized tomography didn't reveal surrenal disease but showed an important liver disease. The patient was free from other cardiac events in the follow-up. Generally, during the digitalis intoxication we observe various rhythm and conduction disturbances. Instead in this case no serious arrhythmias were registered and the main expression of the drug toxicity was an anteroseptal myocardial infarction with undamaged coronary artery. Also the usual extracardiac symptoms and signs of the digitalis intoxication were absent in this case. All these observations can be explained with the pathological increase of the cathecholamine levels, indirectly induced by digitalis; with the direct toxic effect of the drug at the myocardic level; with the contemporary absence of ionic disturbances; with the concomitant liver disease. The direct toxic effect of the digitalis produced an increase in calcium ions availability for the electromechanical coupling and an increase of the intramyocardial pressure; the increase of the adrenergic activity determined contemporary an increase in the oxygen consumption of the myocardial cells, a rise of vascular tone and coronary artery tone and a reduction of the duration of the diastole. All these factors provoked a "primary and secondary" ischemia which evolved toward a real "cathecholamine necrosis" and produced a myocardial infarction. This hypothesis explains the myocardial infarction in absence of injury at the coronary arteriography and without coronary spasm at the ergonovine test; moreover it explains the transient increase in cathecholamine plasma levels observed in the acute phases an normalized after fifteen days. The "cathecholamine necrosis" is an anatomical definition, nevertheless in our opinion it gives account of the rare clinical situation observed.

[The role of the echo-dipyridamole test in the differential diagnosis of chest pain]. / Ruolo del test all'eco-dipiridamolo nella diagnosi differenziale del dolore toracico.

We have verified the utility of echo-dipyridamole test in the diagnosis of chest pain of unsure origin, especially in patients who cannot be quickly submitted to exercise stress test because of permanent abnormalities at basal ECG or because of clinical reasons. 17 patients with chest pain, abnormalities at basal ECG not evolutive and insignificant for myocardial ischemia, absence of enzymatic curve, were admitted to our hospital from September 1988 to January 1990. All these patients were submitted before the ninth and fifteenth day of hospitalization to the echo-dipyridamole test. Drugs were discontinued 3 days before the test. Dipyridamole was administered intravenously in 4 minutes at dosage of 0.56 mg/kg during ECG and echocardiographic monitoring. If no ECG or echocardiographic changes were observed, a second intravenous bolus of dipyridamole at a dosage of 0.28 mg/kg in 2 minutes was made. After the end of infusion continuous ECG and echocardiographic monitoring was performed for 20 minutes at least. Blood pressure was controlled every 3 minutes. Only the major changes in segmental wall motion were considered for analysis to minimize possible errors. Moreover a second physician not present during the test, revised in following the wall motion changes of all the tests. The test was positive in 5 patients (29%) (positive group) and negative in 12 (71%) (negative group). The changes in the heart rate and blood pressure observed during the test were not significantly different in the two groups.(ABSTRACT TRUNCATED AT 250 WORDS)

[Percutaneous coronary angioplasty in the elderly: a report of 2 cases in patients over 90]. / Angioplastica coronarica percutanea nei vecchi: descrizione di due casi in pazienti ultranovantenni.

Percutaneous transluminal coronary angioplasty is a validated method for coronary revascularization over coronary surgery in elderly patients. We describe two cases in patients in their nineties. Case n. 1: a 95-year-old patient with post-infarction angina that was not controlled well by medical therapy. On admission to our department, the patient was in good hemodynamic condition and a transthoracic echocardiographic examination confirmed normal left ventricular systolic function. Coronary angiography showed a severe calcified stenosis of the left anterior descending coronary artery, which was successfully treated with coronary angioplasty and stenting. After three months, the patient was readmitted because of angina. A new coronary angiogram showed diffuse in-stent restenosis, which was successfully treated with rotational atherectomy and angioplasty. The patient was asymptomatic at follow-up after 6 months. Case n. 2: a 91-year-old patient was admitted for an unstable angina. On admission to our department the patient was in good hemodynamic condition. Coronary angiography showed a severe stenosis of the left anterior descending coronary artery that was successfully treated with angioplasty and stenting. The patient was asymptomatic at 6-month follow-up. These cases show that coronary revascularization can successfully be performed even in patients in their nineties when medical therapy is unsuccessful and the patients are considered at high risk for surgery.

[Progression of cardiopathology in Friedreich ataxia: clinico-instrumental study]. / Evoluzione della cardiopatia nell'atassia di Friedreich: studio clinico-strumentale.

Clinical, electrocardiographic and echocardiographic 5-year follow-up was performed in our institution on 61 patients with Friedreich's ataxia. Cardiac failure was evident in 5% of the patients, and was the most common cause of death. Cardiac arrhythmias, most commonly supraventricular in origin, usually occurred together with the onset of cardiac failure and in 1 case resulted in sudden death. ST-T abnormalities were present in 91% of the cases, and were independent from other clinical parameters. On the contrary, pseudonecrotic (5%) and right ventricular hypertrophy pattern were associated with a poor prognosis. Left ventricular hypertrophy was evident at the echocardiogram in 75% of cases and remained unchanged throughout the entire follow-up period. In 1 case left ventricular hypertrophy turned to dilative cardiomyopathy. Autopsy was performed in 2 out of 4 decreased patients and revealed massive interstitial fibrosis with cellular degeneration in the absence of coronary lesions.

Echocardiographic evaluation of verapamil in Friedreich's ataxia.

Nine patients with hypertrophic cardiomyopathy associated with Friedreich's ataxia were treated with the calcium antagonist verapamil, which is known to reduce myocardial hypertrophy and improve diastolic function in patients with idiopathic hypertrophic cardiomyopathy. Daily oral doses of 7 mg/kg were given for a mean (SD) of 24 (8) months. M mode echocardiography performed at the start of the study and at the end of follow up showed no significant difference between the treated group and an untreated control group of nine patients. Verapamil produced no changes in left ventricular wall thickness, mass index, left ventricular internal diameter, fractional shortening, peak normalised lengthening rate, peak rate of septal and posterior wall thinning, and time from minimum ventricular cavity dimension to mitral valve opening. Myocardial calcium overload has been suggested as a cause of cardiac disease in Friedreich's ataxia; however, verapamil had no beneficial effect on these patients with established myocardial hypertrophy.

[Polycardiographic researches on over 90 years old subjects (author's transl)]. / Rilievi policardiografici su soggetti ultranovantenni.

In the recent years an increasing attention has been focused on the systolic time intervals (STI) as reliable indicators of left ventircular contractile performance. As regards the diagnostic usefulness of STI in old persons only few papers can be found in the literature, all of them being concerned with subjects aged less than 90 years. With the aim to assess the usefulness and the reliability of the method and the caracteristics of left ventricular function in the tenth decade, STI as well as heart volume (HV) were determined on a group of 35 subjects aged 90 years and over (mean age 93.2 years) normotensive and free from clinical evidence of heart disease. STI (PEPI, LVETI, QS2I, PEP/LVET) values showed no differences with those considered as normal. A marked increase was recorded for the HV values. These results suggest that in the very advanced age a good level of left ventricular contractile performance can be mantained by the compensatory mechanism represented by heart dilation according to the Frank Starling principle.