Reflectance confocal microscopy - Consensus terminology glossary in Brazilian Portuguese for normal skin, melanocytic and non-melanocytic lesions.

BACKGROUND: Currently, there is no uniform and official terminology in Portuguese for reflectance confocal microscopy analysis, despite the increasing number of Brazilian dermatologists using this new tool. OBJECTIVE: To present the terminology in Brazilian Portuguese for the description of reflectance confocal microscopy and establish the first Brazilian consensus on terms related to normal skin and cutaneous tumors. METHODS: 10 Brazilian specialists from different institutions and states of Brazil were selected to evaluate the best corresponding terms in Portuguese for normal skin, melanocytic and non-melanocytic tumors. The terms used were translated from international consensuses in the English language. The modified Delphi method was used to create the consensus in 3 steps. RESULTS: The terms considered the most appropriate in the Portuguese language to describe the findings of normal skin, melanocytic and non-melanocytic lesions in the reflectance confocal microscopy analysis were presented. STUDY LIMITATIONS: The limitations of the present study include the number of participants and limited regional representation (only two of the five Brazilian regions were represented). CONCLUSION: This Brazilian consensus represents an opportunity for dermatologists and physicians specializing in cutaneous oncology to become familiar with reflectance confocal microscopy, propagating the technique in clinical and research environments to stimulate national and international publications on this subject.

Brazilian Brown Propolis: an Overview About Its Chemical Composition, Botanical Sources, Quality Control, and Pharmacological Properties.

Brazil is one of the largest propolis producers in the world. Propolis is produced by bees from plant exudates and tissues, leading to many variations in the types of propolis. Generally, Brazilian propolis types are green, brown, and red. Despite not being the main research focus as the green and red propolis, brown propolis is the second most produced propolis type in Brazil and has tremendous economic and medicinal importance. Propolis has drawn attention with the rise in the search for healthier lifestyles, functional foods, biocosmetics, and natural products as therapeutic sources. This review covers the main chemical constituents identified in different types of Brazilian brown propolis, and their botanical sources, chemistry, and biological activities. The economic aspect of brown propolis is also presented. There are many gaps to be filled for brown propolis regarding the development of analytical methods, and quality control to allow its standardization, limiting its applicability in the food and pharmaceutical industries. Future perspectives regarding brown propolis research were discussed, especially biological activities, to support the medicinal uses of different types of brown propolis. Supplementary Information: The online version contains supplementary material available at 10.1007/s43450-023-00374-x.

Reflectance confocal microscopy - Consensus terminology glossary in Brazilian Portuguese for normal skin, melanocytic and non-melanocytic lesions

Abstract Background: Currently, there is no uniform and official terminology in Portuguese for reflectance confocal microscopy analysis, despite the increasing number of Brazilian dermatologists using this new tool. Objective: To present the terminology in Brazilian Portuguese for the description of reflectance confocal microscopy and establish the first Brazilian consensus on terms related to normal skin and cutaneous tumors. Methods: 10 Brazilian specialists from different institutions and states of Brazil were selected to evaluate the best corresponding terms in Portuguese for normal skin, melanocytic and non-melanocytic tumors. The terms used were translated from international consensuses in the English language. The modified Delphi method was used to create the consensus in 3 steps. Results: The terms considered the most appropriate in the Portuguese language to describe the findings of normal skin, melanocytic and non-melanocytic lesions in the reflectance confocal microscopy analysis were presented. Study limitations: The limitations of the present study include the number of participants and limited regional representation (only two of the five Brazilian regions were represented). Conclusion: This Brazilian consensus represents an opportunity for dermatologists and physicians specializing in cutaneous oncology to become familiar with reflectance confocal microscopy, propagating the technique in clinical and research environments to stimulate national and international publications on this subject.

O ensino sobre a sistematização da assistência de enfermagem em um curso de graduação / Teaching the systematization of the nursing care in an undergraduate course / Enseñanza sobre la sistematización de la asistencia de enfermería en un curso de pregrado

Objetivo: compreender a percepção de estudantes de um curso de graduação em enfermagem sobre o ensino da sistematização da assistência de enfermagem. Método: pesquisa de métodos mistos, realizada com 156 estudantes de um curso de graduação em enfermagem de uma instituição privada de Belo Horizonte, Minas Gerais, Brasil. Foi utilizado um questionário estruturado e, posteriormente, dez estudantes selecionados aleatoriamente foram entrevistados, sendo utilizado um roteiro semiestruturado. Resultados: os estudantes revelaram ter segurança e conhecimento para implementar a sistematização da assistência de enfermagem e entendem sua importância para a autonomia, segurança e visibilidade profissional, além de avaliar positivamente a forma com que o ensino sobre a temática é desenvolvido na instituição. Conclusão: compreende-se que práticas positivas e metodologias ativas devem ser potencializadas durante a graduação, sendo necessário esforço coletivo que forneça meios para o desenvolvimento da sistematização da assistência de enfermagem.

Objective: to understand the perception of undergraduate nursing students about teaching the systematization of nursing care. Method: mixed methods research, carried out with 156 students from an undergraduate nursing course at a private institution in Belo Horizonte, Minas Gerais, Brazil. A structured questionnaire was used and, later, ten randomly selected students were interviewed, using a semi-structured script. Results: the students showed confidence and knowledge to implement the systematization of nursing care and understand its importance for autonomy, security and professional visibility, in addition to positively evaluating the way in which teaching on the subject is developed in the institution. Conclusion: it is understood that positive practices and active methodologies should be strengthened during graduation, requiring a collective effort to provide means for the development of the systematization of nursing care.

Objetivo: comprender la percepción de los estudiantes de un curso de graduación en enfermería sobre la enseñanza de la sistematización de la asistencia de enfermería. Método: investigación de métodos mixtos, realizada con 156 estudiantes del curso de graduación en enfermería de una institución privada en Belo Horizonte, Minas Gerais, Brasil. Se utilizó un cuestionario estructurado y, posteriormente, se entrevistó a diez estudiantes seleccionados al azar, utilizando un guión semiestructurado. Resultados: los estudiantes mostraron confianza y conocimiento para implementar la sistematización de la asistencia de enfermería y comprender su importancia para la autonomía, seguridad y visibilidad profesional, además de evaluar positivamente la forma en que se desarrolla la enseñanza sobre el tema en la institución. Conclusión: se entiende que las prácticas positivas y las metodologías activas deben ser fortalecidas durante la graduación, requiriendo un esfuerzo colectivo para proporcionar medios para el desarrollo de la sistematización de la asistencia de enfermería.

Method validation and nanoparticle characterization assays for an innovative amphothericin B formulation to reach increased stability and safety in infectious diseases.

Drug Delivery Systems (DDS) of known drugs are prominent candidates towards new and more-effective treatments of various infectious diseases as they may increase drug bioavailability, control drug delivery and target the site of action. In this sense, the encapsulation of Amphotericin B (AmB) in Nanostructured Lipid Carriers (NLCs) designed with pH-sensible phospholipids to target infectious tissues was proposed and suitable analytical methods were validated, as well as, proper nanoparticle characterization were conducted. Characterization assays by Dinamic Light Scattering (DLS) and Atomic Force Microscopy demonstrated spherical particles with nanometric size 268.0±11.8nm and Zeta Potential -42.5±1.5mV suggestive of important stability. DSC/TGA and FT-IR assessments suggested mechanical encapsulation of AmB. The AmB aggregation study indicated that the encapsulation provided AmB at the lowest cytotoxic form, polyaggregate. Analytical methods were developed and validated according to regulatory agencies in order to fast and assertively determine AmB in nanoparticle suspension and, in Drug Encapsulation Efficiency (EE%), release and stability studies. The quantification method for AmB in NLC suspension presented linearity in 5.05-60.60µgmL-1 range (y=0.07659x+0.05344) and for AmB in receptor solution presented linearity in 0.15-10.00µgmL-1 range (y=54609x+263.1), both with r≥0.999. EE% was approximately 100% and according to the release results, at pH 7.4, a sustained controlled profile was observed for up 46h. In the meantime, a micellar AmB solution demonstrated an instability pattern after 7h of contact with the medium. Degradation and release studies under acid conditions (infectious condition) firstly depicted a prominent degradation of AmB (raw-material), with 20.3±3.5% at the first hour, reaching 43.3±7.0% after 7h of study. Next, particles faster disruption in acid environment was evidenced by measuring the NLC size variation by DLS and by the loss of the bluish sheen, characteristic of the nanostructured system macroscopically observed. Finally, safety studies depicted that NLC-AmB presented reduced toxicity in fibroblast cells, corroborating with AmB aggregated form study. Therefore, an innovative AmB formulation was fully characterized and it is a new proposal for in vivo investigations.

Aplasia Cutis Congenita: Trichoscopy Findings.

Aplasia cutis congenita (ACC) is a rare disorder characterized by localized absence of skin that most commonly affects the scalp. We present a case of ACC in a 45-day-old girl and the dermoscopic findings. Dermoscopy has shown to be an easy, fast and useful method for the diagnosis of this condition.

Dermoscopy findings in tinea capitis: case report and literature review.

Dermoscopy is a method of increasing importance in the diagnoses of cutaneous diseases. On the scalp, dermoscopic aspects have been described in psoriasis, lichen planus, seborrheic dermatitis and discoid lupus. We describe the "comma" and "corkscrew hair" dermoscopic aspects found in a child of skin type 4, with tinea capitis.

Spitz nevus: a case report and the use of dermoscopy.

The Spitz nevus is a benign melanocytic lesion with clinical and histopathological features similar to those of melanoma. It was first described in 1948 but great controversy still remains today with respect to its diagnosis and management. The use of dermoscopy may increase diagnostic accuracy. In Spitz nevus, the most common dermoscopic finding is a starburst-like pattern, followed by globular and atypical patterns. Diagnosis must be confirmed by histopathology, particularly in atypical cases.

Clinical and epidemiological study of leprosy cases in the University Hospital of Brasília: 20 years -- 1985 to 2005.

Hansen's disease, also known as leprosy, is an infectious disease still prevalent in Brazil. It is a chronic illness with acute immunological phenomena known as leprosy reactions. In the Federal District of Brazil, the University Hospital of Brasília is the reference centre for leprosy care. The study aimed to characterize the clinical and epidemiological profile of Hansen's disease patients at the University Hospital of Brasília, by descriptive, retrospective analysis of 1,124 patients over the period from 1985 to 2005. The pattern of leprosy in this study demonstrated that type 2 leprosy reactions were common, especially in the lepromatous form and presented a direct correlation with the bacilloscopic index. The prevalence and frequency of severe complications, such as leprosy reactions, emphasize the importance of the ongoing study of leprosy and the need for continual improvement in the scope of knowledge concerning its treatment.

Dermoscopy findings in tinea capitis: case report and literature review / Achados dermatoscópicos na tinea capitis: relato de caso e revisão da literatura

Dermoscopy is a method of increasing importance in the diagnoses of cutaneous diseases. On the scalp, dermoscopic aspects have been described in psoriasis, lichen planus, seborrheic dermatitis and discoid lupus. We describe the "comma" and "corkscrew hair" dermoscopic aspects found in a child of skin type 4, with tinea capitis.

A dermatoscopia é um método que ganha cada vez mais importância na diagnose de diversas dermatoses. No couro cabeludo, já foram descritos os aspectos dermatoscópicos presentes na psoríase, no líquen plano, na dermatite seborréica e no lúpus discóide. Nós descrevemos padrão dermatoscópico de "cabelos em vírgula e em saca rolhas" encontrado em uma criança com fototipo 4, com tinha do couro cabeludo.

Nevo de Spitz: relato de caso e dermatoscopia / Spitz nevus: a case report and the use of dermoscopy

O nevo de Spitz é uma lesão melanocítica benigna com características clínicas e histopatológicas semelhantes às do melanoma. Foi descrito em 1948, mas até hoje, ainda, existe grande controvérsia no seu diagnóstico e conduta. A utilização da dermatoscopia pode aumentar a sua acurácia diagnóstica. As características dermatoscópicas do nevo de Spitz incluem um padrão estelar (starburst), que é o mais frequente, seguido do padrão globular e do padrão atípico. O diagnóstico deve ser confirmado por exame histopatológico, principalmente, nos casos atípicos.

The Spitz nevus is a benign melanocytic lesion with clinical and histopathological features similar to those of melanoma. It was first described in 1948 but great controversy still remains today with respect to its diagnosis and management. The use of dermoscopy may increase diagnostic accuracy. In Spitz nevus, the most common dermoscopic finding is a starburst-like pattern, followed by globular and atypical patterns. Diagnosis must be confirmed by histopathology, particularly in atypical cases.

Estudo epidemiológico dos pacientes idosos queimados no Centro de Tratamento de Queimados do Hospital Instituto Doutor José Frota do município de Fortaleza-CE, no período de 2004 a 2008 / Epidemiological survey of elderly burned patients admitted on Centro de Tratamento de Queimados of Instituto Doutor José Frota Hospital in Fortaleza-CE, from 2004 to 2008

Objetivo: Analisar o perfil epidemiológico dos pacientes idosos internados no Centro de Tratamento de Queimados (CTQ) do Hospital Instituto Doutor José Frota (IJF), no período de 2004 a 2008. Método: Foram avaliados registros de 79 pacientes com idade igual ou superior a 60 anos que estiveram internados no CTQ do IJF durante o período de 2004 a 2008, por meio de um formulário específico. Resultados: Observou-se predominância das internações em indivíduos do sexo masculino (55,7%), com idade média de 72,7 ± 9,03 anos, provenientes de municípios do interior do estado Ceará (58,2%), tendo o fogo como principal agente causal (31,6%) e predominância para as queimaduras de 2º grau, sendo evidenciada taxa de 30% de superfície corporal queimada e 41,8% de mortalidade. Conclusão: Conclui-se que o perfil dos pacientes idosos vítimas de queimaduras internados no CTQ do Instituto Doutor José Frota, no período de 2004 a 2008, é constituído por indivíduos do sexo masculino, procedentes de cidades interioranas do estado do Ceará, tendo o fogo como principal agente causal e predominância para as queimaduras de 2º grau e 41,8% de mortalidade.

Objective: To analyze the elderly patients epidemiological profile in the Centro de Tratamento dos Queimados (CTQ) of Hospital Instituto Doutor José Frota (IJF), between 2004 and 2008. Methods: Records of 79 patients were evaluated, all of them 60 or older that had been hospitalized in the CTQ between 2004 and 2008, using a specific form. Results: The majority of patients were male (55.7%), aged 72.7 ± 9.03 years old, originated from the state's countryside (58.2%), fire was the main causal agent (31.6%), with second degree burns the most common, averaging 30% of burned surface area and 41.8% of mortality was observed. Conclusion: The conclusion was that the profile of burned elderly patients hospitalized in the CTQ of Hopital Instituto José Frota (IJF) between 2004 and 2008, are male patients, from the state's countryside, fire was the principal causal agent and second degree burns the most common with 41.8% of mortality.

Clinical and epidemiological study of leprosy cases in the University Hospital of Brasília: 20 years - 1985 to 2005 / Estudo clínico-epidemiológico dos casos de hanseníase do Hospital Universitário de Brasília: 20 anos - 1985 a 2005

Hansen's disease, also known as leprosy, is an infectious disease still prevalent in Brazil. It is a chronic illness with acute immunological phenomena known as leprosy reactions. In the Federal District of Brazil, the University Hospital of Brasília is the reference centre for leprosy care. The study aimed to characterize the clinical and epidemiological profile of Hansen's disease patients at the University Hospital of Brasília, by descriptive, retrospective analysis of 1,124 patients over the period from 1985 to 2005. The pattern of leprosy in this study demonstrated that type 2 leprosy reactions were common, especially in the lepromatous form and presented a direct correlation with the bacilloscopic index. The prevalence and frequency of severe complications, such as leprosy reactions, emphasize the importance of the ongoing study of leprosy and the need for continual improvement in the scope of knowledge concerning its treatment.

Hanseníase, também conhecida como lepra, é doença infecciosa prevalente no Brasil. Caracteriza-se por curso crônico, com fenômenos imunológicos agudos denominados episódios reacionais. No Distrito Federal, o Hospital Universitário de Brasília é referência na assistência da hanseníase. O objetivo do estudo foi caracterizar o perfil clínico-epidemiológico dos doentes portadores de hanseníase do Hospital Universitário de Brasília. Foi realizada análise descritiva e retrospectiva de 1124 doentes portadores de hanseníase no período de 1985 a 2005. O padrão da hanseníase no nosso estudo concretizou-se por apresentar maior prevalência de reações do tipo 2, especialmente na forma lepromatosa e correlacionando-se diretamente com o índice baciloscópico. A significativa prevalência e freqüência de complicações graves como os episódios reacionais ressaltam a importância do estudo da doença e a necessidade de aprimoramento contínuo dos conhecimentos sobre a mesma.

Hamartoma angiomatoso écrino: relato de caso e estudo clinicopatológico e ultra-sonográfico / Eccrine angiomatous hamartoma: case report and clinical, pathologic and ultrasonographic studies

O hamartoma angiomatoso écrino é neoplasia benigna rara, caracterizada pela proliferação hamartomatosa das glândulas sudoríparas écrinas e dos pequenos vasos sangüíneos. Descrevem-se as características clinicopatológicas e ultra-sonográficas de um nódulo azulado na polpa digital da mão direita, doloroso e produtor de suor, que acometeu uma mulher de 19 anos de idade.

Melanoma cutâneo: características clínicas, epidemiológicas e histopatologicas no Hospital Universitário de Brasília entre janeiro de 1994 e abril de 1999 / Cutaneous melanoma: clinical, epidemiological and histopathological characteristics at the University Hospital of Brasília between january 1994 and april 1999

A incidência do melanoma cutâneo tem aumentado cerca de 4 a 6por cento anualmente. Esse tumor ocorre preferencialmente no sexo feminino, entre 30 e 79 anos de idade e predominantemente em indivíduos de cor branca. A forma anatomopatológica mais freqüente é a extensivo-superficial, e sua localização varia com o sexo. O objetivo deste estudo foi avaliar as características clínicas, epidemiológicas e histológicas do melanoma cutâneo primário, no Hospital Universitário de Brasília, em um período de cinco anos. Foi realizado estudo de revisão dos prontuários dos casos de melanoma cutâneo primário, do Hospital Universitário de Brasília, diagnosticados e tratados entre janeiro de 1994 e abril de 1999, totalizando 32 casos. Os pacientes foram analisados, caracterizando-se a distribuição do tumor por sexo, idade, cor da pele, topografia, sintomatologia, tipo de crescimento, nível de Clark, índice de Breslow e presença de metástases. A análise dos dados foi realizada por meio de estatística simples e pelo teste do qui-quadrado (c2). Neste estudo há predomínio das lesões localizadas nos membros, correspondendo a 16 pacientes (50 por cento). Em nove pacientes (45 por cento) a forma primária era do tipo nodular, e 17 pacientes (58,6 por cento) não apresentavam queixas...

SAE: sistematização da assistência de enfermagem: guia prático / SAE: systematization of nursing care: practical guide

A Sistematização da Assistência de Enfermagem (SAE) é uma atividade privativa do enfermeiro, que através de um método e estratégia de trabalho científico realiza a identificação das situações de saúde / saúde, subsidiando a prescrição e implementação das ações de Assistência de Enfermagem, que possam contribuir para a promoção, prevenção, recuperação e reabilitação em saúde do indivíduo, família e comunidade. A SAE requer do enfermeiro interesse em conhecer o paciente como indivíduo, utilizando para isto seus conhecimentos e habilidades, além de orientação e treinamento da equipe de enfermagem para a implementação das ações sistematizadas