Detalhe da pesquisa
1.
Effects of Drug-Antibody Ratio on Pharmacokinetics, Biodistribution, Efficacy, and Tolerability of Antibody-Maytansinoid Conjugates.
Bioconjug Chem
; 28(5): 1371-1381, 2017 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28388844
2.
Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody-Maytansinoid Conjugates.
Bioconjug Chem
; 27(7): 1588-98, 2016 07 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27174129
3.
RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis.
Nature
; 468(7320): 103-7, 2010 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-20881963
4.
A novel anti-CD37 antibody-drug conjugate with multiple anti-tumor mechanisms for the treatment of B-cell malignancies.
Blood
; 122(20): 3500-10, 2013 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24002446
5.
Bioanalysis of an antibody drug conjugate (ADC) PYX-201 in human plasma using a hybrid immunoaffinity LC-MS/MS approach.
J Chromatogr B Analyt Technol Biomed Life Sci
; 1223: 123715, 2023 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37094503
6.
A sensitive and rapid LC-MS/MS assay for quantitation of free payload Aur0101 from antibody drug conjugate (ADC) PYX-201 in human plasma.
J Chromatogr B Analyt Technol Biomed Life Sci
; 1226: 123786, 2023 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37352642
7.
Quantification of antibody-drug conjugate PYX-201 in rat and monkey plasma via ELISA and its application in preclinical studies.
Bioanalysis
; 15(1): 43-52, 2023 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-36876967
8.
Quantitation of total antibody (tAb) from antibody drug conjugate (ADC) PYX-201 in rat and monkey plasma using an enzyme-linked immunosorbent assay (ELISA) and its application in preclinical studies.
J Pharm Biomed Anal
; 233: 115452, 2023 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37167766
9.
A sensitive LC-MS/MS assay to quantitate free payload Aur0101 from ADC PYX-201 in rat and monkey plasma.
Bioanalysis
; 15(14): 833-843, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37584364
10.
Development and validation of a hybrid immunoaffinity LC-MS/MS assay for quantitation of total antibody (TAb) from an antibody drug conjugate (ADC) PYX-201 in human plasma.
J Chromatogr B Analyt Technol Biomed Life Sci
; 1228: 123844, 2023 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37579604
11.
Dual inactivation of Hus1 and p53 in the mouse mammary gland results in accumulation of damaged cells and impaired tissue regeneration.
Proc Natl Acad Sci U S A
; 106(50): 21282-7, 2009 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19918068
12.
Antibody Co-Administration Can Improve Systemic and Local Distribution of Antibody-Drug Conjugates to Increase In Vivo Efficacy.
Mol Cancer Ther
; 20(1): 203-212, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33177153
13.
An Antibody-Drug Conjugate Targeting MUC1-Associated Carbohydrate CA6 Shows Promising Antitumor Activities.
Mol Cancer Ther
; 19(8): 1660-1669, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32451330
14.
Mutation of the murine Bloom's syndrome gene produces global genome destabilization.
Mol Cell Biol
; 26(17): 6713-26, 2006 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16914751
15.
Evaluation of Prophylactic Corticosteroid Eye Drop Use in the Management of Corneal Abnormalities Induced by the Antibody-Drug Conjugate Mirvetuximab Soravtansine.
Clin Cancer Res
; 25(6): 1727-1736, 2019 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30413525
16.
Bone sialoprotein mediates the tumor cell-targeted prometastatic activity of transforming growth factor beta in a mouse model of breast cancer.
Cancer Res
; 66(12): 6327-35, 2006 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16778210
17.
IMGN779, a Novel CD33-Targeting Antibody-Drug Conjugate with DNA-Alkylating Activity, Exhibits Potent Antitumor Activity in Models of AML.
Mol Cancer Ther
; 17(6): 1271-1279, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29588393
18.
A CD123-targeting antibody-drug conjugate, IMGN632, designed to eradicate AML while sparing normal bone marrow cells.
Blood Adv
; 2(8): 848-858, 2018 04 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29661755
19.
A DNA-Interacting Payload Designed to Eliminate Cross-Linking Improves the Therapeutic Index of Antibody-Drug Conjugates (ADCs).
Mol Cancer Ther
; 17(3): 650-660, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29440292
20.
Indatuximab ravtansine (BT062) combination treatment in multiple myeloma: pre-clinical studies.
J Hematol Oncol
; 10(1): 13, 2017 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28077160