Detalhe da pesquisa
1.
Addressing Today's Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam.
Drug Metab Dispos
; 50(1): 65-75, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34620695
2.
A phase 1 healthy male volunteer single escalating dose study of the pharmacokinetics and pharmacodynamics of risdiplam (RG7916, RO7034067), a SMN2 splicing modifier.
Br J Clin Pharmacol
; 85(1): 181-193, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30302786
3.
In vitro profiling of the metabolism and drug-drug interaction of tofogliflozin, a potent and highly specific sodium-glucose co-transporter 2 inhibitor, using human liver microsomes, human hepatocytes, and recombinant human CYP.
Xenobiotica
; 45(3): 230-8, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25350082
4.
The need for human breast cancer resistance protein substrate and inhibition evaluation in drug discovery and development: why, when, and how?
Drug Metab Dispos
; 42(9): 1466-77, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24989889
5.
Calibration of in vitro multidrug resistance protein 1 substrate and inhibition assays as a basis to support the prediction of clinically relevant interactions in vivo.
Drug Metab Dispos
; 42(9): 1411-22, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24939652
6.
Role of the intestinal peptide transporter PEPT1 in oseltamivir absorption: in vitro and in vivo studies.
Drug Metab Dispos
; 40(8): 1556-65, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22584254
7.
Response to "Breast cancer resistance protein substrate and inhibition evaluation: why, when, and how?".
Drug Metab Dispos
; 42(12): 1981, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25362072
8.
Mechanistic modeling of hepatic transport from cells to whole body: application to napsagatran and fexofenadine.
Mol Pharm
; 6(6): 1716-33, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19739673
9.
Prediction of pharmacokinetic profile of valsartan in human based on in vitro uptake transport data.
J Pharmacokinet Pharmacodyn
; 36(6): 585-611, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19936896
10.
Prediction of pharmacokinetic profile of valsartan in humans based on in vitro uptake-transport data.
Chem Biodivers
; 6(11): 1975-87, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19937834
11.
Design, data analysis, and simulation of in vitro drug transport kinetic experiments using a mechanistic in vitro model.
Drug Metab Dispos
; 36(12): 2434-44, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18809732
12.
Risdiplam distributes and increases SMN protein in both the central nervous system and peripheral organs.
Pharmacol Res Perspect
; 6(6): e00447, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30519476
13.
Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 ( SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA).
J Med Chem
; 61(15): 6501-6517, 2018 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30044619
14.
New strategies to address drug-drug interactions involving OATPs.
Curr Opin Drug Discov Devel
; 10(1): 74-83, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17265745
15.
Effects of Cytochrome P450 3A4 Inhibitors-Ketoconazole and Erythromycin-on Bitopertin Pharmacokinetics and Comparison with Physiologically Based Modelling Predictions.
Clin Pharmacokinet
; 55(2): 237-47, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26341813
16.
Specific Correction of Alternative Survival Motor Neuron 2 Splicing by Small Molecules: Discovery of a Potential Novel Medicine To Treat Spinal Muscular Atrophy.
J Med Chem
; 59(13): 6086-100, 2016 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27299419
17.
Characterization of the transmembrane transport and absolute bioavailability of the HCV protease inhibitor danoprevir.
Clin Pharmacokinet
; 54(5): 537-49, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25488594
18.
PK/PD assessment in CNS drug discovery: Prediction of CSF concentration in rodents for P-glycoprotein substrates and application to in vivo potency estimation.
Biochem Pharmacol
; 85(11): 1684-99, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23454189