Detalhe da pesquisa
1.
Rewiring mitochondrial pyruvate metabolism: switching off the light in cancer cells?
Mol Cell
; 56(3): 343-344, 2014 Nov 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-25514180
2.
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.
Nature
; 477(7363): 225-8, 2011 Aug 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-21849978
3.
OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation.
Proc Natl Acad Sci U S A
; 111(11): 4031-6, 2014 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24550447
4.
Germline mutations in FH confer predisposition to malignant pheochromocytomas and paragangliomas.
Hum Mol Genet
; 23(9): 2440-6, 2014 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24334767
5.
Concise review: genetic dissection of hypoxia signaling pathways in normal and leukemic stem cells.
Stem Cells
; 32(6): 1390-7, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24496882
6.
Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway.
Cancer Cell
; 11(4): 311-9, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17418408
7.
Current morphologic criteria perform poorly in identifying hereditary leiomyomatosis and renal cell carcinoma syndrome-associated uterine leiomyomas.
Int J Gynecol Pathol
; 33(6): 560-7, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25272294
8.
Renal cell carcinoma: translational aspects of metabolism and therapeutic consequences.
Kidney Int
; 84(4): 667-81, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23823604
9.
SDH mutations in cancer.
Biochim Biophys Acta
; 1807(11): 1432-43, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21771581
10.
Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism.
Hum Mol Genet
; 19(19): 3844-51, 2010 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20660115
11.
In the ring with polycystic kidney disease--avoiding the knockout punch.
J Pathol
; 223(1): 1-3, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20938930
12.
Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status.
J Pathol
; 225(1): 4-11, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21630274
13.
Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts.
J Biol Chem
; 284(25): 16767-16775, 2009 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-19386601
14.
An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis.
Lancet Oncol
; 10(8): 764-71, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19576851
15.
Contrasting clinical manifestations of SDHB and VHL associated chromaffin tumours.
Endocr Relat Cancer
; 16(2): 515-25, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19208735
16.
Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha.
Biochem J
; 416(3): 387-94, 2008 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18713068
17.
Clinical manifestations of familial paraganglioma and phaeochromocytomas in succinate dehydrogenase B (SDH-B) gene mutation carriers.
Clin Endocrinol (Oxf)
; 69(4): 587-96, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18419787
18.
Fumarate Hydratase Deletion in Pancreatic ß Cells Leads to Progressive Diabetes.
Cell Rep
; 20(13): 3135-3148, 2017 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28954230
19.
Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions.
J Exp Med
; 214(3): 719-735, 2017 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28202494
20.
Expression of HIF-1alpha, HIF-2alpha (EPAS1), and their target genes in paraganglioma and pheochromocytoma with VHL and SDH mutations.
J Clin Endocrinol Metab
; 91(11): 4593-8, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16954163