RESUMO
The rat experiments were made to compare the wound-healing action of solubilized (aqueous) alpha-tocopherol acetate (SATA) prepared by the original techniques and its official oil-based preparation. A course intravenous SATA (2 mg four times at an interval of 4 days) administration was found to stimulate epithelial regeneration and suppress the formation of connective tissue of uncomplicated skin wounds. By healing the complicated wounds, SATA potentiated the occurrence of an inflammatory reaction and slowed down regeneration, whereas its oily solution failed to produce this effect.
Assuntos
Antioxidantes/farmacologia , Vitamina E/análogos & derivados , Cicatrização/efeitos dos fármacos , alfa-Tocoferol/análogos & derivados , Animais , Antioxidantes/administração & dosagem , Masculino , Ratos , Pele/efeitos dos fármacos , Pele/lesões , Pele/patologia , Solubilidade , Fatores de Tempo , Tocoferóis , Vitamina E/administração & dosagem , Vitamina E/farmacologiaAssuntos
Face , Doenças Maxilomandibulares/diagnóstico , Abscesso/sangue , Abscesso/diagnóstico , Adolescente , Adulto , Ensaios Enzimáticos Clínicos , Feminino , Infecção Focal Dentária/sangue , Infecção Focal Dentária/diagnóstico , Humanos , Doenças Maxilomandibulares/sangue , Masculino , Pessoa de Meia-IdadeRESUMO
The ways of penetration of submandibular salivary degeneration products into the blood after partial gland resection have been studied on 97 rats. Using isoenzyme LDH spectrum of the blood, as well as of gland and regional lymph node tissue, the acid-base balance values and morphological data, it has been shown that degeneration products of salivary glands penetrate into the general blood flow through regional lymph nodes, where they are partly modified. The true changes in LDH spectrum can be already registered half an hour after the injury of the gland. The influence of the degeneration products of gland tissue on the initiation of the compensation processes in cellular hyperplasia is discussed.
Assuntos
Regeneração , Glândula Submandibular/fisiologia , Equilíbrio Ácido-Base , Animais , Dióxido de Carbono/sangue , Isoenzimas , L-Lactato Desidrogenase/sangue , L-Lactato Desidrogenase/metabolismo , Masculino , Necrose , Oxigênio/sangue , Ratos , Glândula Submandibular/metabolismo , Glândula Submandibular/patologiaRESUMO
Experiments on Wistar rats were carried out to examine the changes in protein, glycoprotein, enzymatic and antigenic blood content after sialotomy of the salivary gland with an object of detecting mitogens. It was demonstrated that injury is accompanied by a moderately pronounced dysproteinemia, an increase in the seromucoid fraction, 48 hours after injury, and by variation in the ratio of LDH isozyme fractions, characteristic of the anaerobic metabolic pattern. No antigens of the injured gland were seen in the blood. The evidence obtained does not confirm the participation of high-molecular proteins of the injured gland in the activation of distant proliferation in the corneal epithelium.
Assuntos
Antígenos/análise , Proteínas Sanguíneas/análise , Glicoproteínas/sangue , L-Lactato Desidrogenase/análise , Glândula Submandibular/lesões , Animais , Feminino , Isoenzimas , Masculino , Mitógenos/sangue , Ratos , Ratos Endogâmicos , Regeneração , Glândula Submandibular/enzimologia , Glândula Submandibular/imunologia , Fatores de TempoRESUMO
The preparation KG-62 related to iodomethylates of hydroxyalkyl phosphinic acids with muscarinolytic effect has been studied. The study provides data on the development of experimental gastric ulcer among rats after injections of the preparation. On the basis of morphologic, morphometric and biochemical data it has been stated that the preparation KG-62 in a 5 mg/kg dose has a more strong effect leading to quick gastric ulcer healing. It was supposed that not only suppressing action on hydrochloric acid and pepsinogen secretion lies in the mechanism of the effect but also the activation of physiologic regulation in intact tissue.