RESUMO
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 324 Mexicans from the state of Yucatán living in the city of Mérida (Nâ¯=â¯192) and rural communities (Nâ¯=â¯132), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes in the state of Yucatán include 16 Native American and one European haplotype. Admixture estimates revealed that the main genetic components in Yucatán are Native American (81.54⯱â¯4.99% by ML; 62.92% of Native American haplotypes) and European (11.50⯱â¯15.43% by ML; 23.26% of European haplotypes), and a less prominent African genetic component (6.96⯱â¯10.47% by ML; 5.93% of African haplotypes).
Assuntos
Etnicidade/genética , Variação Genética , Genética Populacional , Antígenos HLA/genética , Alelos , Cidades , Frequência do Gene , Geografia , Haplótipos , Humanos , Desequilíbrio de Ligação , México , População RuralRESUMO
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 98 Mexicans from the state of Quintana Roo living in the city of Cancún (Nâ¯=â¯48) and rural communities (Nâ¯=â¯50), to obtain information regarding allelic and haplotypic frequencies and their linkage disequilibrium. We found that the most frequent haplotypes in Quintana Roo include ten Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in Quintana Roo are Native American (80.85⯱â¯3.70% by ML; 60.20% of Native American haplotypes) and European (15.19⯱â¯14.25% by ML; 26.02% of European haplotypes), and a less prominent African genetic component (3.96⯱â¯10.75% by ML; 6.63% of African haplotypes).
Assuntos
Etnicidade/genética , Variação Genética , Genética Populacional , Antígenos HLA/genética , Alelos , Cidades , Frequência do Gene , Geografia , Haplótipos , Humanos , Desequilíbrio de Ligação , México , População RuralRESUMO
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 81 Mexicans from the state of Campeche living in the city of Campeche (Nâ¯=â¯34) and rural communities (Nâ¯=â¯47), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in the state of Campeche include ten Native American, three European, one African and one Asian haplotype. Admixture estimates revealed that the main genetic components in the state of Campeche are Native American (65.56⯱â¯0.96% by ML; 51.24% of Native American haplotypes), European (34.44⯱â¯10.94% by ML; 30.25% of European haplotypes), and a virtually absent African genetic component (0.00⯱â¯10.31% by ML; 9.26% of African haplotypes).
Assuntos
Etnicidade/genética , Variação Genética , Genética Populacional , Antígenos HLA/genética , Alelos , Cidades , Frequência do Gene , Genótipo , Geografia , Haplótipos , Humanos , Desequilíbrio de Ligação , México , População RuralRESUMO
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 224 Mexicans from the state of Tabasco living in the city of Villahermosa (Nâ¯=â¯82) and rural communities (Nâ¯=â¯142), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes in Tabasco include 13 Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in Tabasco are Native American (67.79⯱â¯1.59% by ML; 56.25% of Native American haplotypes) and European (27.21⯱â¯3.97% by ML; 29.91% of European haplotypes), and a less prominent African genetic component (5.01⯱â¯4.42% by ML; 8.93% of African haplotypes).
Assuntos
Etnicidade/genética , Variação Genética , Genética Populacional , Antígenos HLA/genética , Alelos , Cidades , Frequência do Gene , Geografia , Haplótipos , Humanos , Desequilíbrio de Ligação , México , População RuralRESUMO
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 173 Mexicans from the state of Chiapas living in the city of Tuxtla Gutiérrez (Nâ¯=â¯52) and rural communities (Nâ¯=â¯121), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes in Chiapas include 12 Native American and one European haplotype. Admixture estimates revealed that the main genetic components in Chiapas are Native American (71.61⯱â¯0.58% by ML; 53.16% of Native American haplotypes) and European (26.39⯱â¯5.05% by ML; 25.86% of European haplotypes), and a less prominent African genetic component (2.00⯱â¯5.20% by ML; 9.77% of African haplotypes).