1.
Bioorg Med Chem Lett
; 22(7): 2565-71, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22370269
RESUMO
Purinergic receptor P2X3 has been linked to analgesia in a number of pre-clinical models of pain, and is expressed in the human pain perception pathway. Only few P2X3-selective antagonists have been reported to date. This Letter describes the SAR and in vivo analgesic profile of a novel scaffold of selective P2X3 antagonists.