Detalhe da pesquisa
1.
Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40.
J Biol Chem
; 298(7): 102127, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35709986
2.
Structural Insights into Inhibition of the Acinetobacter-Derived Cephalosporinase ADC-7 by Ceftazidime and Its Boronic Acid Transition State Analog.
Antimicrob Agents Chemother
; 64(12)2020 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32988830
3.
Multiple substitutions lead to increased loop flexibility and expanded specificity in Acinetobacter baumannii carbapenemase OXA-239.
Biochem J
; 475(1): 273-288, 2018 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29229762
4.
Structural basis of activity against aztreonam and extended spectrum cephalosporins for two carbapenem-hydrolyzing class D ß-lactamases from Acinetobacter baumannii.
Biochemistry
; 54(10): 1976-87, 2015 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25710192
5.
Biochemical and structural analysis of inhibitors targeting the ADC-7 cephalosporinase of Acinetobacter baumannii.
Biochemistry
; 53(48): 7670-9, 2014 Dec 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25380506
6.
Structural origins of oxacillinase specificity in class D ß-lactamases.
Antimicrob Agents Chemother
; 58(1): 333-41, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24165180
7.
Class D ß-lactamases: a reappraisal after five decades.
Acc Chem Res
; 46(11): 2407-15, 2013 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-23902256
8.
Structure-based efforts to optimize a non-ß-lactam inhibitor of AmpC ß-lactamase.
Bioorg Med Chem
; 22(13): 3351-9, 2014 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24835785
9.
Structural and Dynamic Features of Acinetobacter baumannii OXA-66 ß-Lactamase Explain Its Stability and Evolution of Novel Variants.
J Mol Biol
; 436(12): 168603, 2024 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38729259
10.
Structures of the class D Carbapenemases OXA-23 and OXA-146: mechanistic basis of activity against carbapenems, extended-spectrum cephalosporins, and aztreonam.
Antimicrob Agents Chemother
; 57(10): 4848-55, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23877677
11.
Sulfonamidoboronic Acids as "Cross-Class" Inhibitors of an Expanded-Spectrum Class C Cephalosporinase, ADC-33, and a Class D Carbapenemase, OXA-24/40: Strategic Compound Design to Combat Resistance in Acinetobacter baumannii.
Antibiotics (Basel)
; 12(4)2023 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-37107006
12.
Synthesis of a Novel Boronic Acid Transition State Inhibitor, MB076: A Heterocyclic Triazole Effectively Inhibits Acinetobacter-Derived Cephalosporinase Variants with an Expanded-Substrate Spectrum.
J Med Chem
; 66(13): 8510-8525, 2023 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37358467
13.
Structural analysis of the Asn152Gly mutant of P99 cephalosporinase.
Acta Crystallogr D Biol Crystallogr
; 68(Pt 9): 1189-93, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22948919
14.
A comprehensive and contemporary "snapshot" of ß-lactamases in carbapenem resistant Acinetobacter baumannii.
Diagn Microbiol Infect Dis
; 99(2): 115242, 2021 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-33248392
15.
1,2,3-Triazolylmethaneboronate: A Structure Activity Relationship Study of a Class of ß-Lactamase Inhibitors against Acinetobacter baumannii Cephalosporinase.
ACS Infect Dis
; 6(7): 1965-1975, 2020 07 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32502340
16.
The 1.4 A crystal structure of the class D beta-lactamase OXA-1 complexed with doripenem.
Biochemistry
; 48(50): 11840-7, 2009 Dec 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-19919101
17.
Structure-Based Analysis of Boronic Acids as Inhibitors of Acinetobacter-Derived Cephalosporinase-7, a Unique Class C ß-Lactamase.
ACS Infect Dis
; 4(3): 325-336, 2018 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29144724
18.
Inhibition of Acinetobacter-Derived Cephalosporinase: Exploring the Carboxylate Recognition Site Using Novel ß-Lactamase Inhibitors.
ACS Infect Dis
; 4(3): 337-348, 2018 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29144725
19.
Exploring the potential of boronic acids as inhibitors of OXA-24/40 ß-lactamase.
Protein Sci
; 26(3): 515-526, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27997706
20.
Structure-based discovery of a novel, noncovalent inhibitor of AmpC beta-lactamase.
Structure
; 10(7): 1013-23, 2002 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12121656