Detalhe da pesquisa
1.
Pharmacological Characterization of the Imipridone Anticancer Drug ONC201 Reveals a Negative Allosteric Mechanism of Action at the D2 Dopamine Receptor.
Mol Pharmacol
; 100(4): 372-387, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34353882
2.
Simulator-based assessment of haptic surgical skill: a comparative study.
Surg Innov
; 22(2): 183-8, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25053621
3.
Integrated stress response and immune cell infiltration in an ibrutinib-refractory mantle cell lymphoma patient following ONC201 treatment.
Br J Haematol
; 185(1): 133-136, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29740811
4.
Imipridones inhibit tumor growth and improve survival in an orthotopic liver metastasis mouse model of human uveal melanoma.
bioRxiv
; 2024 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38293232
5.
The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia.
Cancer Res
; 84(7): 1084-1100, 2024 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38266099
6.
Novel antineoplastics targeting genetic changes in colorectal cancer.
Adv Exp Med Biol
; 779: 1-34, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23288633
7.
ONC201/TIC10 plus TLY012 anti-cancer effects via apoptosis inhibitor downregulation, stimulation of integrated stress response and death receptor DR5 in gastric adenocarcinoma.
Am J Cancer Res
; 13(12): 6290-6312, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-38187068
8.
A novel dopamine receptor D2 antagonist (ONC206) potentiates the effects of olaparib in endometrial cancer.
Cancer Biol Ther
; 24(1): 2202104, 2023 12 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37069726
9.
Novel combination of imipridones and histone deacetylase inhibitors demonstrate cytotoxic effect through integrated stress response in pediatric solid tumors.
Am J Cancer Res
; 13(12): 6241-6255, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-38187038
10.
Resveratrol induces p53-independent, X-linked inhibitor of apoptosis protein (XIAP)-mediated Bax protein oligomerization on mitochondria to initiate cytochrome c release and caspase activation.
J Biol Chem
; 286(33): 28749-28760, 2011 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-21712378
11.
Assessing surgeon and novice force skill on a haptic stiffness simulator for laparoscopic surgery.
Stud Health Technol Inform
; 173: 469-74, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22357038
12.
Phase II Study of ONC201 in Neuroendocrine Tumors including Pheochromocytoma-Paraganglioma and Desmoplastic Small Round Cell Tumor.
Clin Cancer Res
; 28(9): 1773-1782, 2022 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35022321
13.
ONC206 has anti-tumorigenic effects in human ovarian cancer cells and in a transgenic mouse model of high-grade serous ovarian cancer.
Am J Cancer Res
; 12(2): 521-536, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35261784
14.
Anti-Tumor and Anti-Invasive Effects of ONC201 on Ovarian Cancer Cells and a Transgenic Mouse Model of Serous Ovarian Cancer.
Front Oncol
; 12: 789450, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35372029
15.
Induction of Synthetic Lethality by Activation of Mitochondrial ClpP and Inhibition of HDAC1/2 in Glioblastoma.
Clin Cancer Res
; 28(9): 1881-1895, 2022 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35417530
16.
Quantitation of the next-generation imipridone ONC206 in human plasma by a simple and sensitive UPLC-MS/MS assay for clinical pharmacokinetic application.
J Pharm Biomed Anal
; 213: 114685, 2022 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35219065
17.
Extracellular Matrix in Synthetic Hydrogel-Based Prostate Cancer Organoids Regulate Therapeutic Response to EZH2 and DRD2 Inhibitors.
Adv Mater
; 34(2): e2100096, 2022 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-34676924
18.
Role of haptic feedback in a basic laparoscopic task requiring hand-eye coordination.
Stud Health Technol Inform
; 163: 591-3, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21335862
19.
Potent preclinical sensitivity to imipridone-based combination therapies in oncohistone H3K27M-mutant diffuse intrinsic pontine glioma is associated with induction of the integrated stress response, TRAIL death receptor DR5, reduced ClpX and apoptosis.
Am J Cancer Res
; 11(9): 4607-4623, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34659909
20.
Highly potent dopamine receptor D2 antagonist ONC206 demonstrates anti-tumorigenic activity in endometrial cancer.
Am J Cancer Res
; 11(11): 5374-5387, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34873466