1.
J Org Chem
; 87(21): 13763-13789, 2022 11 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36206491
RESUMO
A systematic study of the effect of various 6-O-acyl groups on anomeric selectivity in glucosylations with thioglycoside donors was conducted. All eight different esters were found to induce moderate-to-high α-selectivity in glucosylation with l-menthol with the best being 6-O-p-nitrobenzoyl. The effect appears to be general across various glucosyl acceptors, glucosyl donor types, and modes of activation. No evidence was found in favor of distal participation.