Expectation violations produce error signals in mouse V1.

Repeated exposure to visual sequences changes the form of evoked activity in the primary visual cortex (V1). Predictive coding theory provides a potential explanation for this, namely that plasticity shapes cortical circuits to encode spatiotemporal predictions and that subsequent responses are modulated by the degree to which actual inputs match these expectations. Here we use a recently developed statistical modeling technique called Model-Based Targeted Dimensionality Reduction (MbTDR) to study visually evoked dynamics in mouse V1 in the context of an experimental paradigm called "sequence learning." We report that evoked spiking activity changed significantly with training, in a manner generally consistent with the predictive coding framework. Neural responses to expected stimuli were suppressed in a late window (100-150 ms) after stimulus onset following training, whereas responses to novel stimuli were not. Substituting a novel stimulus for a familiar one led to increases in firing that persisted for at least 300 ms. Omitting predictable stimuli in trained animals also led to increased firing at the expected time of stimulus onset. Finally, we show that spiking data can be used to accurately decode time within the sequence. Our findings are consistent with the idea that plasticity in early visual circuits is involved in coding spatiotemporal information.

Efficient Temporal Coding in the Early Visual System: Existing Evidence and Future Directions.

While it is universally accepted that the brain makes predictions, there is little agreement about how this is accomplished and under which conditions. Accurate prediction requires neural circuits to learn and store spatiotemporal patterns observed in the natural environment, but it is not obvious how such information should be stored, or encoded. Information theory provides a mathematical formalism that can be used to measure the efficiency and utility of different coding schemes for data transfer and storage. This theory shows that codes become efficient when they remove predictable, redundant spatial and temporal information. Efficient coding has been used to understand retinal computations and may also be relevant to understanding more complicated temporal processing in visual cortex. However, the literature on efficient coding in cortex is varied and can be confusing since the same terms are used to mean different things in different experimental and theoretical contexts. In this work, we attempt to provide a clear summary of the theoretical relationship between efficient coding and temporal prediction, and review evidence that efficient coding principles explain computations in the retina. We then apply the same framework to computations occurring in early visuocortical areas, arguing that data from rodents is largely consistent with the predictions of this model. Finally, we review and respond to criticisms of efficient coding and suggest ways that this theory might be used to design future experiments, with particular focus on understanding the extent to which neural circuits make predictions from efficient representations of environmental statistics.