Detalhe da pesquisa
1.
Zinc finger nuclease knock-out of NADPH:cytochrome P450 oxidoreductase (POR) in human tumor cell lines demonstrates that hypoxia-activated prodrugs differ in POR dependence.
J Biol Chem
; 288(52): 37138-53, 2013 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24196959
2.
Mechanism of action of AminoCBIs: highly reactive but highly cytotoxic analogues of the duocarmycins.
Chembiochem
; 15(13): 1998-2006, 2014 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25087870
3.
Novel nitroimidazole alkylsulfonamides as hypoxic cell radiosensitisers.
Bioorg Med Chem
; 22(7): 2123-32, 2014 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24650701
4.
Clinical relevance and therapeutic predictive ability of hypoxia biomarkers in head and neck cancer tumour models.
Mol Oncol
; 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38426642
5.
The effect of sulfonate leaving groups on the hypoxia-selective toxicity of nitro analogs of the duocarmycins.
Bioorg Med Chem
; 19(16): 4851-60, 2011 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21767954
6.
The effect of a bromide leaving group on the properties of nitro analogs of the duocarmycins as hypoxia-activated prodrugs and phosphate pre-prodrugs for antitumor therapy.
Bioorg Med Chem
; 19(20): 5989-98, 2011 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21920763
7.
Engineering the Escherichia coli Nitroreductase NfsA to Create a Flexible Enzyme-Prodrug Activation System.
Front Pharmacol
; 12: 701456, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34163368
8.
Spatially-resolved pharmacokinetic/pharmacodynamic modelling of bystander effects of a nitrochloromethylbenzindoline hypoxia-activated prodrug.
Cancer Chemother Pharmacol
; 88(4): 673-687, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34245333
9.
Hypoxic selectivity and solubility--investigating the properties of A-ring substituted nitro seco-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-ones (nitroCBIs) as hypoxia-activated prodrugs for antitumor therapy.
Bioorg Med Chem
; 18(14): 4997-5006, 2010 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20580559
10.
The cytotoxicity of duocarmycin analogues is mediated through alkylation of DNA, not aldehyde dehydrogenase 1: a comment.
Angew Chem Int Ed Engl
; 52(21): 5442-6, 2013 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-23616474
11.
Bystander Effects of Hypoxia-Activated Prodrugs: Agent-Based Modeling Using Three Dimensional Cell Cultures.
Front Pharmacol
; 9: 1013, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30279659
12.
Cellular pharmacology of evofosfamide (TH-302): A critical re-evaluation of its bystander effects.
Biochem Pharmacol
; 156: 265-280, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30134191
13.
Next-Generation Hypoxic Cell Radiosensitizers: Nitroimidazole Alkylsulfonamides.
J Med Chem
; 61(3): 1241-1254, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29253343
14.
Oxygen dependence and extravascular transport of hypoxia-activated prodrugs: comparison of the dinitrobenzamide mustard PR-104A and tirapazamine.
Int J Radiat Oncol Biol Phys
; 69(2): 560-71, 2007 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17869669
15.
Synthesis and structure-activity relationships for 2,4-dinitrobenzamide-5-mustards as prodrugs for the Escherichia coli nfsB nitroreductase in gene therapy.
J Med Chem
; 50(6): 1197-212, 2007 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-17326614
16.
Pharmacokinetic/pharmacodynamic model-guided identification of hypoxia-selective 1,2,4-benzotriazine 1,4-dioxides with antitumor activity: the role of extravascular transport.
J Med Chem
; 50(25): 6392-404, 2007 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-18001018
17.
Hypoxia-selective 3-alkyl 1,2,4-benzotriazine 1,4-dioxides: the influence of hydrogen bond donors on extravascular transport and antitumor activity.
J Med Chem
; 50(26): 6654-64, 2007 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-18052317
18.
Influence of a Basic Side Chain on the Properties of Hypoxia-Selective Nitro Analogues of the Duocarmycins: Demonstration of Substantial Anticancer Activity in Combination with Irradiation or Chemotherapy.
J Med Chem
; 60(13): 5834-5856, 2017 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28644035
19.
Reductive Metabolism Influences the Toxicity and Pharmacokinetics of the Hypoxia-Targeted Benzotriazine Di-Oxide Anticancer Agent SN30000 in Mice.
Front Pharmacol
; 8: 531, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28848445
20.
Multicellular resistance to tirapazamine is due to restricted extravascular transport: a pharmacokinetic/pharmacodynamic study in HT29 multicellular layer cultures.
Cancer Res
; 63(18): 5970-7, 2003 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-14522924