Detalhe da pesquisa
1.
Nonclinical cardiovascular safety evaluation of romosozumab, an inhibitor of sclerostin for the treatment of osteoporosis in postmenopausal women at high risk of fracture.
Regul Toxicol Pharmacol
; 115: 104697, 2020 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-32590049
2.
Scientific Review of the Proarrhythmic Risks of Oligonucleotide Therapeutics: Are Dedicated ICH S7B/E14 Studies Needed for Low-Risk Modalities?
Clin Pharmacol Ther
; 116(1): 96-105, 2024 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-38362953
3.
Supporting an integrated QTc risk assessment using the hERG margin distributions for three positive control agents derived from multiple laboratories and on multiple occasions.
J Pharmacol Toxicol Methods
; 128: 107524, 2024 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38852689
4.
Itraconazole decreases left ventricular contractility in isolated rabbit heart: mechanism of action.
Toxicol Appl Pharmacol
; 268(2): 113-22, 2013 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23416206
5.
Time Is a Critical Factor When Evaluating Oligonucleotide Therapeutics in hERG Assays.
Nucleic Acid Ther
; 33(2): 132-140, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36576986
6.
Assessment of sarcomere shortening and calcium transient in primary human and dog ventricular myocytes.
J Pharmacol Toxicol Methods
; 123: 107278, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37268094
7.
BeKm-1, a peptide inhibitor of human ether-a-go-go-related gene potassium currents, prolongs QTc intervals in isolated rabbit heart.
J Pharmacol Exp Ther
; 337(1): 2-8, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21205913
8.
Validation of using cardioplegic solutions for preserving cardiac function in isolated rabbit heart assays.
J Pharmacol Toxicol Methods
; 111: 107082, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34082139
9.
Comprehensive in vitro pro-arrhythmic assays demonstrate that omecamtiv mecarbil has low pro-arrhythmic risk.
Clin Transl Sci
; 14(4): 1600-1610, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33955165
10.
Time for a Fully Integrated Nonclinical-Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective.
Clin Pharmacol Ther
; 109(2): 310-318, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32866317
11.
Effects of omecamtiv mecarbil on calcium-transients and contractility in a translational canine myocyte model.
Pharmacol Res Perspect
; 8(5): e00656, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32969560
12.
Inotropic assessment in engineered 3D cardiac tissues using human induced pluripotent stem cell-derived cardiomyocytes in the BiowireTM II platform.
J Pharmacol Toxicol Methods
; 105: 106886, 2020 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-32629159
13.
Cardiovascular response to small-molecule APJ activation.
JCI Insight
; 5(8)2020 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32208384
14.
Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors.
Bioorg Med Chem Lett
; 19(22): 6307-12, 2009 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19819693
15.
Blinded In Silico Drug Trial Reveals the Minimum Set of Ion Channels for Torsades de Pointes Risk Assessment.
Front Pharmacol
; 10: 1643, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-32082155
16.
Decreased contractility and altered responses to inotropic agents in myocytes from tachypacing-induced heart failure canines.
J Pharmacol Toxicol Methods
; 93: 98-107, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29908289
17.
Action Potential Recording and Pro-arrhythmia Risk Analysis in Human Ventricular Trabeculae.
Front Physiol
; 8: 1109, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29354071
18.
Proarrhythmia Risk Assessment in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Using the Maestro MEA Platform.
Toxicol Sci
; 147(1): 286-95, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26117837
19.
Oxytocin does not directly alter cardiac repolarization in rabbit or human cardiac myocytes.
Pharmacol Res Perspect
; 3(1): e00102, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25692020
20.
Human embryonic stem cell derived cardiac myocytes detect hERG-mediated repolarization effects, but not Nav1.5 induced depolarization delay.
J Pharmacol Toxicol Methods
; 68(1): 74-81, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23518063