Detalhe da pesquisa
1.
Efficacy and safety of temelimab in multiple sclerosis: Results of a randomized phase 2b and extension study.
Mult Scler
; 28(3): 429-440, 2022 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-34240656
2.
DSM265 at 400 Milligrams Clears Asexual Stage Parasites but Not Mature Gametocytes from the Blood of Healthy Subjects Experimentally Infected with Plasmodium falciparum.
Antimicrob Agents Chemother
; 63(4)2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30858218
3.
A Single-Dose Combination Study with the Experimental Antimalarials Artefenomel and DSM265 To Determine Safety and Antimalarial Activity against Blood-Stage Plasmodium falciparum in Healthy Volunteers.
Antimicrob Agents Chemother
; 64(1)2019 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31685476
4.
A Phase II pilot trial to evaluate safety and efficacy of ferroquine against early Plasmodium falciparum in an induced blood-stage malaria infection study.
Malar J
; 15: 469, 2016 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27624471
5.
Critical role for phosphoinositide 3-kinase gamma in parasite invasion and disease progression of cutaneous leishmaniasis.
Proc Natl Acad Sci U S A
; 109(4): 1251-6, 2012 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-22232690
6.
The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors.
Nat Chem Biol
; 6(2): 117-24, 2010 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20081827
7.
PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus.
Nat Med
; 11(9): 933-5, 2005 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16127435
8.
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.
Nat Med
; 11(9): 936-43, 2005 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16127437
9.
Phosphoinositide-3 kinase gamma activity contributes to sepsis and organ damage by altering neutrophil recruitment.
Am J Respir Crit Care Med
; 182(6): 762-73, 2010 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20508212
10.
PI3Kgamma (PI3Kgamma) is essential for efficient induction of CXCR3 on activated T cells.
Blood
; 112(8): 3048-51, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18658026
11.
PI3Kgamma regulates cartilage damage in chronic inflammatory arthritis.
FASEB J
; 23(12): 4288-98, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19734303
12.
Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes.
Circulation
; 117(10): 1310-7, 2008 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-18268153
13.
PI3Kgamma inhibition: towards an 'aspirin of the 21st century'?
Nat Rev Drug Discov
; 5(11): 903-18, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17080027
14.
Improved safety margin for embryotoxicity in rats for the new endoperoxide artefenomel (OZ439) as compared to artesunate.
Birth Defects Res
; 110(7): 553-578, 2018 04 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-29193867
15.
Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study.
Lancet Infect Dis
; 18(8): 874-883, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29909069
16.
The p110delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors.
Nat Chem Biol
; 6(3): 244, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20154668
17.
Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study.
Lancet Infect Dis
; 17(6): 626-635, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28363636
18.
DSM265 for Plasmodium falciparum chemoprophylaxis: a randomised, double blinded, phase 1 trial with controlled human malaria infection.
Lancet Infect Dis
; 17(6): 636-644, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28363637
19.
Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma.
J Med Chem
; 49(13): 3857-71, 2006 Jun 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-16789742
20.
Isoform-selective phosphoinositide 3-kinase inhibitors induce apoptosis in chronic lymphocytic leukaemia cells.
Br J Haematol
; 150(1): 108-11, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20230409