Detalhe da pesquisa
1.
Correction of both NBD1 energetics and domain interface is required to restore ΔF508 CFTR folding and function.
Cell
; 148(1-2): 150-63, 2012 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-22265408
2.
pH profiles of 3-chymotrypsin-like protease (3CLpro) from SARS-CoV-2 elucidate its catalytic mechanism and a histidine residue critical for activity.
J Biol Chem
; 299(2): 102790, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36509143
3.
Key Allosteric and Active Site Residues of SARS-CoV-2 3CLpro Are Promising Drug Targets.
Biochem J
; 2023 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37254750
4.
Key dimer interface residues impact the catalytic activity of 3CLpro, the main protease of SARS-CoV-2.
J Biol Chem
; 298(6): 102023, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35568197
5.
Therapeutic potential of metal ions for COVID-19: insights from the papain-like protease of SARS-CoV-2.
Biochem J
; 479(20): 2175-2193, 2022 10 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36205308
6.
The Discovery of Novel Small Oxindole-Based Inhibitors Targeting the SARS-CoV-2 Main Protease (Mpro ).
Chem Biodivers
; 20(11): e202301176, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37861105
7.
Linker residues regulate the activity and stability of hexokinase 2, a promising anticancer target.
J Biol Chem
; 296: 100071, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33187984
8.
Dimethyl sulfoxide reduces the stability but enhances catalytic activity of the main SARS-CoV-2 protease 3CLpro.
FASEB J
; 35(8): e21774, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34324734
9.
The Discovery of Small Allosteric and Active Site Inhibitors of the SARS-CoV-2 Main Protease via Structure-Based Virtual Screening and Biological Evaluation.
Molecules
; 27(19)2022 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36235244
10.
Hexokinase II-derived cell-penetrating peptide targets mitochondria and triggers apoptosis in cancer cells.
FASEB J
; 31(5): 2168-2184, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28183803
11.
Modular Bi-Directional One-Pot Strategies for the Diastereoselective Synthesis of Structurally Diverse Collections of Constrained ß-Carboline-Benzoxazepines.
Chemistry
; 23(57): 14182-14192, 2017 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28770556
12.
Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect.
Hum Mol Genet
; 21(3): 623-34, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22038833
13.
Discovery of pyrimidoindol and benzylpyrrolyl inhibitors targeting SARS-CoV-2 main protease (Mpro) through pharmacophore modelling, covalent docking, and biological evaluation.
J Mol Graph Model
; 127: 108672, 2024 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37992552
14.
SARS-CoV-2 variants, its recombinants and epigenomic exploitation of host defenses.
Biochim Biophys Acta Mol Basis Dis
; 1869(8): 166836, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37549720
15.
Catalytic Dyad Residues His41 and Cys145 Impact the Catalytic Activity and Overall Conformational Fold of the Main SARS-CoV-2 Protease 3-Chymotrypsin-Like Protease.
Front Chem
; 9: 692168, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34249864
16.
Nicotinamide riboside kinase structures reveal new pathways to NAD+.
PLoS Biol
; 5(10): e263, 2007 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-17914902
17.
Biochemical and biophysical characterization of the main protease, 3-chymotrypsin-like protease (3CLpro) from the novel coronavirus SARS-CoV 2.
Sci Rep
; 10(1): 22200, 2020 12 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33335206
18.
Effect of mutation of lysine-120, located at the entry to the active site of O-acetylserine sulfhydrylase-A from Salmonella typhimurium.
Biochim Biophys Acta
; 1784(4): 629-37, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18243146
19.
Role of Histidine-152 in cofactor orientation in the PLP-dependent O-acetylserine sulfhydrylase reaction.
Arch Biochem Biophys
; 472(2): 115-25, 2008 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18275838
20.
The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation.
Biosci Rep
; 38(1)2018 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29298880