Detalhe da pesquisa
1.
Antibody-mediated neutralization of autocrine Gas6 inhibits the growth of pancreatic ductal adenocarcinoma tumors in vivo.
Int J Cancer
; 139(6): 1340-9, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27170265
2.
Antagonism of Ang-Tie2 and Dll4-Notch signaling has opposing effects on tumor endothelial cell proliferation, evidenced by a new flow cytometry method.
Lab Invest
; 94(11): 1296-308, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25243900
3.
AMG 900, a potent inhibitor of aurora kinases causes pharmacodynamic changes in p-Histone H3 immunoreactivity in human tumor xenografts and proliferating mouse tissues.
J Transl Med
; 12: 307, 2014 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-25367255
4.
Wild-Type KRAS Is Required for Panitumumab Efficacy in Patients With Metastatic Colorectal Cancer.
J Clin Oncol
; 41(18): 3278-3286, 2023 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37315390
5.
Tumor penetration and epidermal growth factor receptor saturation by panitumumab correlate with antitumor activity in a preclinical model of human cancer.
Mol Cancer
; 11: 47, 2012 Jul 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-22830443
6.
Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2.
Cancer Cell
; 6(5): 507-16, 2004 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-15542434
7.
Efficacy of ganitumab (AMG 479), alone and in combination with rapamycin, in Ewing's and osteogenic sarcoma models.
J Pharmacol Exp Ther
; 337(3): 644-54, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21385891
8.
Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors.
Bioorg Med Chem Lett
; 21(8): 2394-9, 2011 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21414779
9.
Broad antitumor activity in breast cancer xenografts by motesanib, a highly selective, oral inhibitor of vascular endothelial growth factor, platelet-derived growth factor, and Kit receptors.
Clin Cancer Res
; 15(1): 110-8, 2009 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19118038
10.
Effects of palifermin on antitumor activity of chemotherapeutic and biological agents in human head and neck and colorectal carcinoma xenograft models.
Mol Cancer Res
; 6(8): 1337-46, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18708365
11.
Augmentation of radiation response by panitumumab in models of upper aerodigestive tract cancer.
Int J Radiat Oncol Biol Phys
; 72(2): 534-42, 2008 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18793955
12.
Association of K-ras mutational status and clinical outcomes in patients with metastatic colorectal cancer receiving panitumumab alone.
Clin Colorectal Cancer
; 7(3): 184-90, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18621636
13.
AMG 102, a fully human anti-hepatocyte growth factor/scatter factor neutralizing antibody, enhances the efficacy of temozolomide or docetaxel in U-87 MG cells and xenografts.
Clin Cancer Res
; 13(22 Pt 1): 6735-42, 2007 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18006775
14.
Discovery and evaluation of dual CDK1 and CDK2 inhibitors.
Cancer Res
; 66(8): 4299-308, 2006 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16618755
15.
Fully human monoclonal antibodies to hepatocyte growth factor with therapeutic potential against hepatocyte growth factor/c-Met-dependent human tumors.
Cancer Res
; 66(3): 1721-9, 2006 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16452232
16.
Down-regulation of c-Met inhibits growth in the liver of human colorectal carcinoma cells.
Cancer Res
; 63(11): 2990-6, 2003 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12782608
17.
In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models.
Mol Cancer Ther
; 15(7): 1568-79, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27196782
18.
Blockade of insulin-like growth factor I receptor function inhibits growth and angiogenesis of colon cancer.
Clin Cancer Res
; 8(10): 3259-69, 2002 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-12374697
19.
The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents.
Mol Cancer Ther
; 14(3): 649-58, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25567130
20.
Oxopyrido[2,3-d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors.
ACS Med Chem Lett
; 6(9): 987-92, 2015 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26396685