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Nat Commun ; 7: 10584, 2016 Feb 04.
Artigo em Inglês | MEDLINE | ID: mdl-26843463

RESUMO

GABAergic interneurons play key roles in cortical circuits, yet little is known about their early connectivity. Here we use glutamate uncaging and a novel optogenetic strategy to track changes in the afferent and efferent synaptic connections of developing neocortical interneuron subtypes. We find that Nkx2-1-derived interneurons possess functional synaptic connections before emerging pyramidal cell networks. Subsequent interneuron circuit maturation is both subtype and layer dependent. Glutamatergic input onto fast spiking (FS), but not somatostatin-positive, non-FS interneurons increases over development. Interneurons of both subtype located in layers (L) 4 and 5b engage in transient circuits that disappear after the somatosensory critical period. These include a pathway mediated by L5b somatostatin-positive interneurons that specifically targets L4 during the first postnatal week. The innervation patterns of immature cortical interneuron circuits are thus neither static nor progressively strengthened but follow a layer-specific choreography of transient connections that differ from those of the adult brain.


Assuntos
Neurônios GABAérgicos , Interneurônios , Neocórtex/crescimento & desenvolvimento , Rede Nervosa/crescimento & desenvolvimento , Sinapses , Animais , Animais Recém-Nascidos , Análise por Conglomerados , Proteínas de Fluorescência Verde , Imuno-Histoquímica , Camundongos , Proteínas Nucleares , Optogenética , Técnicas de Patch-Clamp , Análise de Componente Principal , Células Piramidais , Fator Nuclear 1 de Tireoide , Fatores de Transcrição
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