Detalhe da pesquisa
1.
The design, synthesis and structure-activity relationships associated with C28 amine-based betulinic acid derivatives as inhibitors of HIV-1 maturation.
Bioorg Med Chem Lett
; 28(9): 1550-1557, 2018 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29631960
2.
Inhibitors of HIV-1 attachment: The discovery and structure-activity relationships of tetrahydroisoquinolines as replacements for the piperazine benzamide in the 3-glyoxylyl 6-azaindole pharmacophore.
Bioorg Med Chem Lett
; 26(1): 160-7, 2016 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26584882
3.
Inhibitors of HIV-1 maturation: Development of structure-activity relationship for C-28 amides based on C-3 benzoic acid-modified triterpenoids.
Bioorg Med Chem Lett
; 26(8): 1925-30, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26988305
4.
C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors.
Bioorg Med Chem
; 24(8): 1757-70, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26968652
5.
Inhibitors of HIV-1 attachment. Part 10. The discovery and structure-activity relationships of 4-azaindole cores.
Bioorg Med Chem Lett
; 23(1): 213-7, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23200254
6.
Inhibitors of HIV-1 attachment. Part 11: the discovery and structure-activity relationships associated with 4,6-diazaindole cores.
Bioorg Med Chem Lett
; 23(1): 218-22, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23206859
7.
The Discovery of GSK3640254, a Next-Generation Inhibitor of HIV-1 Maturation.
J Med Chem
; 65(18): 11927-11948, 2022 09 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36044257
8.
Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1 H-cyclopenta[ a]chrysen-9-yl)benzoic Acid (GSK3532795, BMS-955176).
J Med Chem
; 61(16): 7289-7313, 2018 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30067361
9.
Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity.
ACS Med Chem Lett
; 7(6): 568-72, 2016 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27326328
10.
Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment 13. Synthesis and profiling of a novel amminium prodrug of the HIV-1 attachment inhibitor BMS-585248.
J Med Chem
; 56(4): 1670-6, 2013 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23374053
11.
Disposition of cisapride appears to be influenced by P-glycoprotein in the mouse.
Clin Pharmacol Ther
; 77(3): 225-6, 2005 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15735616
12.
Characterization of the UDP glucuronosyltransferase activity of human liver microsomes genotyped for the UGT1A1*28 polymorphism.
Drug Metab Dispos
; 35(12): 2270-80, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17898154
13.
The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model.
Drug Metab Dispos
; 33(1): 165-74, 2005 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-15502009