Detalhe da pesquisa
1.
MAA868, a novel FXI antibody with a unique binding mode, shows durable effects on markers of anticoagulation in humans.
Blood
; 133(13): 1507-1516, 2019 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30692123
2.
Structure-based design and optimization of potent inhibitors of the adenoviral protease.
Bioorg Med Chem Lett
; 25(3): 438-43, 2015 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25571794
3.
Ligandability Assessment of IL-1ß by Integrated Hit Identification Approaches.
J Med Chem
; 67(10): 8141-8160, 2024 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38728572
4.
Discovery of a selective and biologically active low-molecular weight antagonist of human interleukin-1ß.
Nat Commun
; 14(1): 5497, 2023 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37679328
5.
Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors.
ACS Med Chem Lett
; 11(2): 188-194, 2020 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32071687
6.
Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach.
J Med Chem
; 63(15): 8088-8113, 2020 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32551603
7.
Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
J Med Chem
; 63(11): 5697-5722, 2020 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32073845
8.
Affinity classification of kinase inhibitors by mass spectrometric methods and validation using standard IC(50) measurements.
Anal Chem
; 81(1): 408-19, 2009 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19067573
9.
Chaperone over-expression in Escherichia coli: apparent increased yields of soluble recombinant protein kinases are due mainly to soluble aggregates.
Protein Expr Purif
; 64(2): 185-93, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19038347
10.
NMR-Based Strategies to Elucidate Bioactive Conformations of Weakly Binding Ligands.
Top Curr Chem
; 273: 1-14, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-23605457
11.
Structure of neprilysin in complex with the active metabolite of sacubitril.
Sci Rep
; 6: 27909, 2016 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27302413
12.
Selective estrogen receptor modulators with conformationally restricted side chains. Synthesis and structure-activity relationship of ERalpha-selective tetrahydroisoquinoline ligands.
J Med Chem
; 48(2): 364-79, 2005 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-15658851
13.
Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics.
J Med Chem
; 48(16): 5175-90, 2005 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-16078837
14.
The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1ß.
MAbs
; 7(6): 1151-60, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26284424
15.
The likelihood of aggregation during protein renaturation can be assessed using the second virial coefficient.
Protein Sci
; 12(4): 708-16, 2003 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-12649429
16.
Discovery and structure-based optimization of adenain inhibitors.
ACS Med Chem Lett
; 5(8): 937-41, 2014 Aug 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-25147618
17.
Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes.
J Biol Chem
; 284(13): 8812-21, 2009 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-19153082
18.
Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1.
J Mol Biol
; 380(5): 828-43, 2008 Jul 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-18589439
19.
Remedial strategies in structural proteomics: expression, purification, and crystallization of the Vav1/Rac1 complex.
Protein Expr Purif
; 53(1): 51-62, 2007 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-17275330
20.
Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs.
ChemMedChem
; 1(2): 267-73, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16892359