Detalhe da pesquisa
1.
Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.
Mol Cell
; 73(5): 1001-1014.e8, 2019 03 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30527540
2.
Dynamic reversibility of α-synuclein serine-129 phosphorylation is impaired in synucleinopathy models.
EMBO Rep
; 24(12): e57145, 2023 Dec 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37870370
3.
Activation of ß2-adrenergic receptors prevents AD-type synaptotoxicity via epigenetic mechanisms.
Mol Psychiatry
; 28(11): 4877-4888, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37365243
4.
Pathogenic Mechanisms of Cytosolic and Membrane-Enriched α-Synuclein Converge on Fatty Acid Homeostasis.
J Neurosci
; 42(10): 2116-2130, 2022 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35086904
5.
The effects of KTKEGV repeat motif and intervening ATVA sequence on α-synuclein solubility and assembly.
J Neurochem
; 165(2): 246-258, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36625497
6.
Excess membrane binding of monomeric alpha-, beta- and gamma-synuclein is invariably associated with inclusion formation and toxicity.
Hum Mol Genet
; 30(23): 2332-2346, 2021 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34254125
7.
Temperature is a key determinant of alpha- and beta-synuclein membrane interactions in neurons.
J Biol Chem
; 296: 100271, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33428933
8.
Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase.
Proc Natl Acad Sci U S A
; 116(41): 20760-20769, 2019 10 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31548371
9.
Functional integrity of the contractile actin cortex is safeguarded by multiple Diaphanous-related formins.
Proc Natl Acad Sci U S A
; 116(9): 3594-3603, 2019 02 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30808751
10.
Upregulation of Cellular Palmitoylation Mitigates α-Synuclein Accumulation and Neurotoxicity.
Mov Disord
; 36(2): 348-359, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33103814
11.
Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor.
Int J Mol Sci
; 21(15)2020 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32707907
12.
Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells.
Hum Mol Genet
; 26(18): 3466-3481, 2017 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28911198
13.
Adding hydrophobicity or positive charges to the cytosolic half of the α-synuclein 3-11 helix increases membrane association and S129 phosphorylation.
FEBS Lett
; 598(2): 210-219, 2024 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37989349
14.
A stem cell-based assay platform demonstrates alpha-synuclein dependent synaptic dysfunction in patient-derived cortical neurons.
NPJ Parkinsons Dis
; 10(1): 107, 2024 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38773105
15.
Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity.
NPJ Parkinsons Dis
; 9(1): 4, 2023 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36646701
16.
Studying α-Synuclein Conformation by Intact-Cell Cross-Linking.
Methods Mol Biol
; 1948: 77-91, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30771172
17.
α-Synuclein serine129 phosphorylation - the physiology of pathology.
Mol Neurodegener
; 18(1): 84, 2023 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37953316
18.
Guanabenz promotes neuronal survival via enhancement of ATF4 and parkin expression in models of Parkinson disease.
Exp Neurol
; 303: 95-107, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29432724
19.
Characterization of the Ste20-like kinase Krs1 of Dictyostelium discoideum.
Eur J Cell Biol
; 85(9-10): 1059-68, 2006 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16842885
20.
An mDia1-INF2 formin activation cascade facilitated by IQGAP1 regulates stable microtubules in migrating cells.
Mol Biol Cell
; 27(11): 1797-808, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27030671