Detalhe da pesquisa
1.
A human microdose study of the antimalarial drug GSK3191607 in healthy volunteers.
Br J Clin Pharmacol
; 84(3): 482-489, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29168205
2.
Design and synthesis of 6-phenylnicotinamide derivatives as antagonists of TRPV1.
Bioorg Med Chem Lett
; 18(20): 5609-13, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18809327
3.
Characterization of SB-705498, a potent and selective vanilloid receptor-1 (VR1/TRPV1) antagonist that inhibits the capsaicin-, acid-, and heat-mediated activation of the receptor.
J Pharmacol Exp Ther
; 321(3): 1183-92, 2007 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-17392405
4.
Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development.
Bioorg Med Chem Lett
; 16(12): 3287-91, 2006 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16580202
5.
N-Tetrahydroquinolinyl, N-quinolinyl and N-isoquinolinyl biaryl carboxamides as antagonists of TRPV1.
Bioorg Med Chem Lett
; 16(17): 4533-6, 2006 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16806913
6.
3,4-Dihydro-2H-benzoxazinones are 5-HT(1A) receptor antagonists with potent 5-HT reuptake inhibitory activity.
Bioorg Med Chem Lett
; 15(3): 737-41, 2005 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15664848
7.
Evidence for a molecular mechanism of teratogenicity of SB-236057, a 5-HT1B receptor inverse agonist that alters axial formation.
Birth Defects Res A Clin Mol Teratol
; 70(10): 789-807, 2004 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-15472891
8.
Discovery of small molecule antagonists of TRPV1.
Bioorg Med Chem Lett
; 14(14): 3631-4, 2004 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-15203132