Detalhe da pesquisa
1.
Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.
Nature
; 535(7610): 148-52, 2016 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27362227
2.
Randomized window of opportunity trial evaluating high-dose vitamin D in breast cancer patients.
Breast Cancer Res Treat
; 178(2): 347-356, 2019 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-31399931
3.
Discovery of Darovasertib (NVP-LXS196), a Pan-PKC Inhibitor for the Treatment of Metastatic Uveal Melanoma.
J Med Chem
; 67(2): 1447-1459, 2024 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38198520
4.
Cryptosphaerolide, a cytotoxic Mcl-1 inhibitor from a marine-derived ascomycete related to the genus Cryptosphaeria.
J Nat Prod
; 73(5): 998-1001, 2010 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-20462271
5.
Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer.
J Med Chem
; 63(22): 13578-13594, 2020 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32910655
6.
Genetic predictors of antipsychotic response to lurasidone identified in a genome wide association study and by schizophrenia risk genes.
Schizophr Res
; 192: 194-204, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28431800
7.
Dual Allosteric Inhibition of SHP2 Phosphatase.
ACS Chem Biol
; 13(3): 647-656, 2018 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29304282
8.
Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor.
J Med Chem
; 59(17): 7773-82, 2016 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27347692
9.
Estrogen receptor beta isoforms exhibit differences in ligand-activated transcriptional activity in an estrogen response element sequence-dependent manner.
Endocrinology
; 145(1): 149-60, 2004 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-14500565
10.
Glucagon-like peptide 1 receptor (GLP1R) haplotypes correlate with altered response to multiple antipsychotics in the CATIE trial.
Schizophr Res
; 160(1-3): 73-9, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25449714
11.
Replication of SULT4A1-1 as a pharmacogenetic marker of olanzapine response and evidence of lower weight gain in the high response group.
Pharmacogenomics
; 15(7): 933-9, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24956247
12.
Genotypic variation in the SV2C gene impacts response to atypical antipsychotics the CATIE study.
Schizophr Res
; 149(1-3): 21-5, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23886675
13.
Sulfotransferase 4A1 Haplotype 1 (SULT4A1-1) Is Associated With Decreased Hospitalization Events in Antipsychotic-Treated Patients With Schizophrenia.
Prim Care Companion CNS Disord
; 14(3)2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23106027
14.
Evidence for a SULT4A1 haplotype correlating with baseline psychopathology and atypical antipsychotic response.
Pharmacogenomics
; 12(4): 471-80, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21521020
15.
AAL881, a novel small molecule inhibitor of RAF and vascular endothelial growth factor receptor activities, blocks the growth of malignant glioma.
Cancer Res
; 66(17): 8722-30, 2006 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16951188