RESUMO
OBJECTIVE: To evaluate the occurrence and in vitro minimum inhibitory concentrations of different Candida species against nine antifungal agents in blood and urine. METHODS: The prospective descriptive study was conducted at The Children's Hospital, Lahore, Pakistan, from June 2015 to May 2016. Identification of the Candid aspecies was done by API (Analytical Profile Index) Candida (bioMerieux) and in vitro minimum inhibitory concentration break points were reported by using Sensititre Yeast One. Data was analysed using SPSS 20. RESULTS: Of the 87 samples, 68(78.2%) were isolated from blood and 19(21.8%) from urine specimens. Also, 66 (75.9%) samples were non-albicans Candida, 31(35.6%) Candida parapsilosis and 21(24.1%) were Candida albicans. Besides, 83(95.4%) strains exhibited excellent susceptibility pattern with the three echinocandins at minimum inhibitory concentration endpoint of ≤2µg/ml and all (100%) the strains inhibited by ≤1µg/ml of voriconazole. None (0%) of the C. albicans isolates was resistant to an antifungal agent. CONCLUSIONS: Excellent susceptibility pattern against antifungal agents was found with an increasing resistance trend towards non-albicans Candida species.