Detalhe da pesquisa
1.
Translation of nonclinical to clinical safety findings for 27 biotherapeutics.
Toxicol Appl Pharmacol
; 484: 116854, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38346540
2.
Nonclinical Safety Signals in PharmaPendium Improve the Predictability of Human Drug-Induced Liver Injury.
Chem Res Toxicol
; 35(11): 2133-2144, 2022 11 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36287557
3.
Most Influential Physicochemical and In Vitro Assay Descriptors for Hepatotoxicity and Nephrotoxicity Prediction.
Chem Res Toxicol
; 33(7): 1780-1790, 2020 07 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32338883
4.
Evaluation of in Vitro Mitochondrial Toxicity Assays and Physicochemical Properties for Prediction of Organ Toxicity Using 228 Pharmaceutical Drugs.
Chem Res Toxicol
; 32(1): 156-167, 2019 01 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30525499
5.
Prediction of metabolism-induced hepatotoxicity on three-dimensional hepatic cell culture and enzyme microarrays.
Arch Toxicol
; 92(3): 1295-1310, 2018 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-29167929
6.
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Bioorg Med Chem Lett
; 26(16): 4003-6, 2016 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27397500
7.
Juvenile toxicity study of PF-07256472/recifercept, a recombinant human soluble fibroblast growth factor receptor 3, in 2-3-month-old cynomolgus monkeys.
Birth Defects Res
; 115(3): 348-356, 2023 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36367445
8.
Fingerprinting heterocellular ß-adrenoceptor functional expression in the brain using agonist activity profiles.
Front Mol Biosci
; 10: 1214102, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37664183
9.
Assessment of drug-induced mitochondrial dysfunction via altered cellular respiration and acidification measured in a 96-well platform.
J Bioenerg Biomembr
; 44(4): 421-37, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22689143
10.
Cyclosporine A and palmitic acid treatment synergistically induce cytotoxicity in HepG2 cells.
Toxicol Appl Pharmacol
; 261(2): 172-80, 2012 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22521608
11.
Burden of cytokines storm on prognosis of SARS-CoV-2 infection through immune response: dynamic analysis and optimal control with immunomodulatory therapy.
Eur Phys J Spec Top
; 231(18-20): 3297-3315, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35103099
12.
Hepatotoxicity reports in the FDA adverse event reporting system database: A comparison of drugs that cause injury via mitochondrial or other mechanisms.
Acta Pharm Sin B
; 11(12): 3857-3868, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-35024312
13.
Novel, Selective Inhibitors of USP7 Uncover Multiple Mechanisms of Antitumor Activity In Vitro and In Vivo.
Mol Cancer Ther
; 19(10): 1970-1980, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32788207
14.
Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity.
J Med Chem
; 63(10): 5398-5420, 2020 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32302140
15.
Utilization of iPSC-derived human neurons for high-throughput drug-induced peripheral neuropathy screening.
Toxicol In Vitro
; 45(Pt 1): 111-118, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28843493
16.
Palmitate increases the susceptibility of cells to drug-induced toxicity: an in vitro method to identify drugs with potential contraindications in patients with metabolic disease.
Toxicol Sci
; 129(2): 346-62, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22700542
17.
Characterization of human-induced pluripotent stem cell-derived cardiomyocytes: bioenergetics and utilization in safety screening.
Toxicol Sci
; 130(1): 117-31, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22843568
18.
Profiling of toxicity and identification of distinct apoptosis profiles using a 384-well high-throughput flow cytometry screening platform.
J Biomol Screen
; 17(6): 806-12, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22496094
19.
Mitochondrial membrane potential measurement of H9c2 cells grown in high-glucose and galactose-containing media does not provide additional predictivity towards mitochondrial assessment.
Toxicol In Vitro
; 25(2): 580-7, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21126567