Detalhe da pesquisa
1.
Spontaneous Selection of Cryptosporidium Drug Resistance in a Calf Model of Infection.
Antimicrob Agents Chemother
; 65(6)2021 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33753338
2.
Methionyl-tRNA synthetase inhibitor has potent in vivo activity in a novel Giardia lamblia luciferase murine infection model.
J Antimicrob Chemother
; 75(5): 1218-1227, 2020 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32011682
3.
Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Cryptosporidium Infection.
Antimicrob Agents Chemother
; 63(4)2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30745384
4.
Development of Methionyl-tRNA Synthetase Inhibitors as Antibiotics for Gram-Positive Bacterial Infections.
Antimicrob Agents Chemother
; 61(11)2017 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28848016
5.
Optimization of a binding fragment targeting the "enlarged methionine pocket" leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors.
Bioorg Med Chem Lett
; 27(12): 2702-2707, 2017 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28465105
6.
Discovery of N-(2-aminoethyl)-N-benzyloxyphenyl benzamides: New potent Trypanosoma brucei inhibitors.
Bioorg Med Chem
; 25(5): 1571-1584, 2017 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28187957
7.
A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.
Acta Crystallogr D Biol Crystallogr
; 71(Pt 8): 1684-98, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26249349
8.
Inhibitors of methionyl-tRNA synthetase have potent activity against Giardia intestinalis trophozoites.
Antimicrob Agents Chemother
; 59(11): 7128-31, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26324270
9.
Induced resistance to methionyl-tRNA synthetase inhibitors in Trypanosoma brucei is due to overexpression of the target.
Antimicrob Agents Chemother
; 57(7): 3021-8, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23587950
10.
Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against Trypanosoma brucei.
RSC Med Chem
; 11(8): 885-895, 2020 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33479683
11.
Triazolopyrimidines and Imidazopyridines: Structure-Activity Relationships and in Vivo Efficacy for Trypanosomiasis.
ACS Med Chem Lett
; 10(1): 105-110, 2019 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30655955
12.
The crystal structure of the drug target Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with a catalytic intermediate.
Acta Crystallogr F Struct Biol Commun
; 74(Pt 4): 245-254, 2018 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29633973
13.
1-Benzyl-3-aryl-2-thiohydantoin Derivatives as New Anti-Trypanosoma brucei Agents: SAR and in Vivo Efficacy.
ACS Med Chem Lett
; 8(8): 886-891, 2017 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28835807
14.
New Class of Antitrypanosomal Agents Based on Imidazopyridines.
ACS Med Chem Lett
; 8(7): 766-770, 2017 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28740614
15.
Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts.
Biochimie
; 138: 124-136, 2017 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-28427904
16.
From Cells to Mice to Target: Characterization of NEU-1053 (SB-443342) and Its Analogues for Treatment of Human African Trypanosomiasis.
ACS Infect Dis
; 3(3): 225-236, 2017 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28110521
17.
Urea Derivatives of 2-Aryl-benzothiazol-5-amines: A New Class of Potential Drugs for Human African Trypanosomiasis.
J Med Chem
; 60(3): 957-971, 2017 02 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27992217
18.
Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors.
Eur J Med Chem
; 124: 1081-1092, 2016 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-27788467
19.
Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.
PLoS One
; 11(8): e0160350, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27500735
20.
Correction: Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.
PLoS One
; 11(9): e0163641, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27658298