Confident futures: Community-based organizations as first responders and agents of change in the face of the Covid-19 pandemic.

This comparative study of community organizations serving marginalized youth in New York City and Amsterdam utilized a novel ethnographic approach called reverse engineering to identify techniques for social change that are active in each organization, adaptable and translatable to other contexts. It found that youth-serving organizations led flexible responses to the crisis of COVID-19 as it affected those marginalized by race, immigrant status, housing instability, religion and gender. The organizations employed techniques that they had previously developed to cultivate youth well-being - among them connectivity, safe space, and creativity - to mount tailored responses to COVID-19 related crises. In New York City, these groups addressed crises of material survival resources (personal protective equipment, food, housing) whereas in Amsterdam, youth-serving organizations focused on social connections and emotional well-being as the government met more of participants' material needs.

'We are all in the image of God': reproductive imaginaries and prenatal genetic testing in American Jewish communities.

How are we to understand the complexities of prenatal genetic testing across social and cultural worlds? Availability and uptake of this biotechnology is variable, deeply influenced not only by national frameworks but also by local regimes of value. We argue that these intersections of genetic testing and local cultural worlds must be understood as part of broader 'reproductive imaginaries', including everything from kinship, pregnancy and gender norms to children's links to specific community norms of national and cultural futures. In the USA, preconceptual/prenatal genetic testing is widely available, driven by a neoliberal market-based model of consumer choice. In contrast, such tests are far more restricted by bioethical laws and medical regulations in France. This article will examine how particular cultural and religious communities - primarily American orthodox Jewish communities - shape prenatal genetic testing in their own distinct ways.

Toward an Ethically Sensitive Implementation of Noninvasive Prenatal Screening in the Global Context.

Noninvasive prenatal screening using cell-free DNA, which analyzes placental DNA circulating in maternal blood to provide information about fetal chromosomal disorders early in pregnancy and without risk to the fetus, has been hailed as a potential "paradigm shift" in prenatal genetic screening. Commercial provision of cell-free DNA screening has contributed to a rapid expansion of the tests included in the screening panels. The tests can include screening for sex chromosome anomalies, rare subchromosomal microdeletions and aneuploidies, and most recently, the entire fetal genome. The benefits of this screening tool are generally framed, by both providers and commercial laboratories, as enhancing reproductive autonomy and choice by providing an earlier, simpler, and more accurate screening while potentially reducing the need for invasive follow-up testing. The majority of the literature has explored these issues empirically or conceptually from a European or North American vantage point, one that assumes normative priorities such as individual reproductive autonomy and the clinical availability of maternal health care or prenatal screening programs within which cell-free DNA screening is offered. While its implementation has raised both challenges and opportunities, very little is known about real-world experiences and the implications of the rapid introduction of cell-free DNA screening outside of North America and Europe, especially in low- and middle-income countries. To begin addressing this gap in knowledge, we organized a four-day international workshop to explore the ethical, legal, social, economic, clinical, and practical implications of the global expansion of cell-free DNA screening. We describe eight key insights that arose from the workshop.

The use of race variables in genetic studies of complex traits and the goal of reducing health disparities: a transdisciplinary perspective.

The use of racial variables in genetic studies has become a matter of intense public debate, with implications for research design and translation into practice. Using research on smoking as a springboard, the authors examine the history of racial categories, current research practices, and arguments for and against using race variables in genetic analyses. The authors argue that the sociopolitical constructs appropriate for monitoring health disparities are not appropriate for use in genetic studies investigating the etiology of complex diseases. More powerful methods for addressing population structure exist, and race variables are unacceptable as gross proxies for numerous social/environmental factors that disproportionately affect minority populations. The authors conclude with recommendations for genetic researchers and policymakers, aimed at facilitating better science and producing new knowledge useful for reducing health disparities.

Entangled ethnography: imagining a future for young adults with learning disabilities.

Our article draws on one aspect of our multi-sited long-term ethnographic research in New York City on cultural innovation and Learning Disabilities (LD). We focus on our efforts to help create two innovative transition programs that also became sites for our study when we discovered that young adults with disabilities were too often "transitioning to nowhere" as they left high school. Because of our stakes in this process as parents of children with learning disabilities as well as anthropologists, we have come to think of our method as entangled ethnography, bringing the insights of both insider and outsider perspectives into productive dialog, tailoring a longstanding approach in critical anthropology to research demedicalizing the experience of disability.

Sociocultural differences in the impact of amniocentesis: an anthropological research report.

This research report describes an anthropological study of the social impact and cultural meaning of prenatal diagnosis in New York City. Research parameters, findings and suggestions for designing future prenatal testing services are outlined. The ethnocultural and socioeconomic diversity of those whose lives are touched by prenatal genetic testing is stressed.