RESUMO
Mastocytosis is a rare disease with reported high interleukin-6 (IL6) levels influencing disease severity. The present study investigated polymorphisms within the genes that encode IL6 and its receptor (IL6R) in relation to mastocytosis development in a case-control design. Analysis of the IL6R Asp358Ala polymorphism showed that carriers of the AA genotype had a 2·5-fold lower risk for mastocytosis than those with the AC or CC genotypes. No association with mastocytosis was found for the IL6-174G/C polymorphism, however, it may influence the effect of IL6R polymorphism. To the best of our knowledge this is the first study analysing IL6/IL6R polymorphisms in mastocytosis.
Assuntos
Interleucina-6/genética , Mastocitose/genética , Polimorfismo de Nucleotídeo Único , Receptores de Interleucina-6/genética , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Alelos , Áustria/epidemiologia , Estudos de Casos e Controles , Epistasia Genética , Feminino , Frequência do Gene , Predisposição Genética para Doença , Genótipo , Humanos , Hungria/epidemiologia , Leucemia de Mastócitos/genética , Masculino , Mastocitose/epidemiologia , Pessoa de Meia-Idade , Polônia/epidemiologia , Adulto JovemRESUMO
BACKGROUND: Ischemic heart disease (IDH) mortality is generally accepted as an indicator of socio-economic conditions. In view of the health status of future generations, sudden cardiac deaths among adolescents and young adults are a considerable focus of attention of public health specialists. In a changing social environment, the rate of sudden deaths in youths could be a sensitive indicator in the evaluation of health effects. Coronary artery anomalies, myocarditis and cardiomyopathies are the most common causes of sudden cardiac deaths in adolescents, and young adults. The aim of this study was to detect the changes in the rate of ischemic heart disease mortality among young people before and after the socio-economic change of 1989 in Hungary. MATERIAL AND METHOD: Data on ischemic mortality were collected from the years 1979-2000. Death certificates were obtained from the Office for National Statistics. RESULTS: There was a significant reduction in coronary mortality in young male adults in the age group of 20-24 years (OR=1.69, CI=1.23-2.32, p=0.00082), 25-29 years (OR=1.3, CI=1.11-1.53, p=0.00094) and 30-34 years (OR=1.37, CI=1.25-1.51, p=0.0000001) after the socio-economic change of 1989. Among young females, the mortality showed a reduction only in the age group of 20-24 years (OR=1.69, CI=1.18-2.45, p=0.039). DISCUSSION: Mortality rates of ischemic heart disease in adolescents and young adults may reflect the changes of socio-economic conditions. Early detection and treatment of youths at risk of premature IHD offers the greatest promise and an opportunity for gender-specific interventions.