Detalhe da pesquisa
1.
Piperlongumine and some of its analogs inhibit selectively the human immunoproteasome over the constitutive proteasome.
Biochem Biophys Res Commun
; 496(3): 961-966, 2018 02 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29355526
2.
Insights into the activity control of the kallikrein-related peptidase 6: small-molecule modulators and allosterism.
Biol Chem
; 399(9): 1073-1078, 2018 09 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29641412
3.
Phenoxypropanolamine derivatives as selective inhibitors of the 20S proteasome ß1 and ß5 subunits.
Bioorg Med Chem Lett
; 27(23): 5172-5178, 2017 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29113763
4.
Identification of a ß1/ß2-specific sulfonamide proteasome ligand by crystallographic screening.
Angew Chem Int Ed Engl
; 54(38): 11275-8, 2015 Sep 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26242779
5.
New C(4)- and C(1)-derivatives of furo[3,4-c]pyridine-3-ones and related compounds: evidence for site-specific inhibition of the constitutive proteasome and its immunoisoform.
Bioorg Med Chem Lett
; 24(6): 1571-80, 2014 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24534487
6.
1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases.
Bioorg Med Chem Lett
; 23(16): 4547-51, 2013 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23849879
7.
C1 and N5 derivatives of cerpegin: synthesis of a new series based on structure-activity relationships to optimize their inhibitory effect on 20S proteasome.
Bioorg Med Chem Lett
; 23(9): 2696-703, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23541650
8.
A new series of N5 derivatives of the 1,1,5-trimethyl furo[3,4-c]pyridine-3,4-dione (cerpegin) selectively inhibits the post-acid activity of mammalian 20S proteasomes.
Bioorg Med Chem Lett
; 22(11): 3822-7, 2012 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22560566
9.
[The proteasome - structural aspects and inhibitors: a second life for a validated drug target]. / Le protéasome, la seconde vie d'une cible thérapeutique validée : aspects structuraux et nouveaux inhibiteurs.
Biol Aujourdhui
; 215(1-2): 1-23, 2021.
Artigo
em Francês
| MEDLINE | ID: mdl-34397372
10.
[Induced degradation of proteins by PROTACs and other strategies: towards promising drugs]. / Dégradation induite des protéines par des molécules PROTAC et stratégies apparentées : développements à visée thérapeutique.
Biol Aujourdhui
; 215(1-2): 25-43, 2021.
Artigo
em Francês
| MEDLINE | ID: mdl-34397373
11.
The HIV-1 Nucleocapsid Regulates Its Own Condensation by Phase-Separated Activity-Enhancing Sequestration of the Viral Protease during Maturation.
Viruses
; 13(11)2021 11 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34835118
12.
Mutational analysis of the CG recognizing DNA methyltransferase SssI: insight into enzyme-DNA interactions.
Biochim Biophys Acta
; 1794(11): 1654-62, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19654054
13.
Structural Studies on the Inhibitory Binding Mode of Aromatic Coumarinic Esters to Human Kallikrein-Related Peptidase 7.
J Med Chem
; 63(11): 5723-5733, 2020 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32374603
14.
Dimer disruption and monomer sequestration by alkyl tripeptides are successful strategies for inhibiting wild-type and multidrug-resistant mutated HIV-1 proteases.
Biochemistry
; 48(2): 379-87, 2009 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-19105629
15.
Coumarinic derivatives show anti-inflammatory effects on alveolar macrophages, but their anti-elastase activity is essential to reduce lung inflammation in vivo.
Int Immunopharmacol
; 9(1): 49-54, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18840548
16.
Novel fluorinated pseudopeptides as proteasome inhibitors.
Bioorg Med Chem Lett
; 19(1): 83-6, 2009 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19041239
17.
Towards the control of intracellular protein turnover: mitochondrial Lon protease inhibitors versus proteasome inhibitors.
Biochimie
; 90(2): 260-9, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18021745
18.
Liberation of an N-terminal proline-rich peptide from the cryptic proteinase of fibronectin by auto-proteolysis.
Arch Biochem Biophys
; 479(2): 158-62, 2008 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18789884
19.
Structure-based design of human immuno- and constitutive proteasomes inhibitors.
Eur J Med Chem
; 145: 570-587, 2018 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29339252
20.
Linear TMC-95-based proteasome inhibitors.
J Med Chem
; 50(12): 2842-50, 2007 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17511440