Detalhe da pesquisa
1.
A kinase-cGAS cascade to synthesize a therapeutic STING activator.
Nature
; 603(7901): 439-444, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35296845
2.
Two-Dimensional SEC-SEC-UV-MALS-dRI Workflow for Streamlined Analysis and Characterization of Biopharmaceuticals.
Anal Chem
; 96(12): 4960-4968, 2024 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38436624
3.
Accelerating Pharmaceutical Process Development with an Acoustic Droplet Ejection-Multiple Reaction Monitoring-Mass Spectrometry Workflow.
Anal Chem
; 96(3): 1138-1146, 2024 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38165811
4.
Automated Online-Sampling Multidimensional Liquid Chromatography with Feedback-Control Capability as a Framework for Real-Time Monitoring of mAb Critical Quality Attributes in Multiple Bioreactors.
Anal Chem
; 95(49): 18130-18138, 2023 12 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38015205
5.
In Silico Method Development of Achiral and Chiral Tandem Column Reversed-phase Liquid Chromatography for Multicomponent Pharmaceutical Mixtures.
Anal Chem
; 94(9): 4065-4071, 2022 03 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35199987
6.
Deuterated Modifiers in Sub/Supercritical Fluid Chromatography for Streamlined NMR Structure Elucidation.
Anal Chem
; 94(35): 12176-12184, 2022 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36001377
7.
Automated Hydrophobic Interaction Chromatography Screening Combined with In Silico Optimization as a Framework for Nondenaturing Analysis and Purification of Biopharmaceuticals.
Anal Chem
; 94(49): 17131-17141, 2022 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36441925
8.
Selective Plate-Based Assay for Trace EDTA Analysis via Boron Trifluoride-methanol Derivatization UHPLC-QqQ-MS/MS Enabling Biologic and Vaccine Processes.
Anal Chem
; 94(3): 1678-1685, 2022 01 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34928586
9.
Enantioselective UHPLC Screening Combined with In Silico Modeling for Streamlined Development of Ultrafast Enantiopurity Assays.
Anal Chem
; 94(3): 1804-1812, 2022 01 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34931812
10.
Automated ion exchange chromatography screening combined with in silico multifactorial simulation for efficient method development and purification of biopharmaceutical targets.
Anal Bioanal Chem
; 414(12): 3581-3591, 2022 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-35441858
11.
Dual-Gradient Unified Chromatography: A New Paradigm for Versatility in Simultaneous Multicomponent Analysis.
Angew Chem Int Ed Engl
; 61(45): e202208854, 2022 11 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36111975
12.
Trapping-Enrichment Multi-dimensional Liquid Chromatography with On-Line Deuterated Solvent Exchange for Streamlined Structure Elucidation at the Microgram Scale.
Angew Chem Int Ed Engl
; 61(21): e202117655, 2022 05 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35139257
13.
In Silico Multifactorial Modeling for Streamlined Development and Optimization of Two-Dimensional Liquid Chromatography.
Anal Chem
; 93(33): 11532-11539, 2021 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34375071
14.
Mapping the Separation Landscape in Two-Dimensional Liquid Chromatography: Blueprints for Efficient Analysis and Purification of Pharmaceuticals Enabled by Computer-Assisted Modeling.
Anal Chem
; 93(2): 964-972, 2021 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33301312
15.
Electrochemical Synthesis of Hindered Primary and Secondary Amines via Proton-Coupled Electron Transfer.
J Am Chem Soc
; 142(1): 468-478, 2020 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31849221
16.
Introducing Multifactorial Peak Crossover in Analytical and Preparative Chromatography via Computer-Assisted Modeling.
Anal Chem
; 92(19): 13443-13451, 2020 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32786491
17.
The Emergence of Universal Chromatographic Methods in the Research and Development of New Drug Substances.
Acc Chem Res
; 52(7): 1990-2002, 2019 07 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31198042
18.
Comprehensive online multicolumn two-dimensional liquid chromatography-diode array detection-mass spectrometry workflow as a framework for chromatographic screening and analysis of new drug substances.
Anal Bioanal Chem
; 412(11): 2655-2663, 2020 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-32128644
19.
Denigrins and Dactylpyrroles, Arylpyrrole Alkaloids from a Dactylia sp. Marine Sponge.
J Nat Prod
; 83(11): 3464-3470, 2020 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33151696
20.
Chaotropic Effects in Sub/Supercritical Fluid Chromatography via Ammonium Hydroxide in Water-Rich Modifiers: Enabling Separation of Peptides and Highly Polar Pharmaceuticals at the Preparative Scale.
Anal Chem
; 91(21): 13907-13915, 2019 11 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31549812