1.
Bioorg Med Chem Lett
; 14(24): 6017-21, 2004 Dec 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15546720
RESUMO
New inhibitors of palmitoyl-CoA oxidation are based on the introduction of nitrogen heterocycles in the 'Western Portion' of the molecule. SAR studies led to the discovery of CVT-4325 (shown), a potent FOXi (IC50=380 nM rat mitochondria) with favorable PK properties (F=93%, t(1/2)=13.6h, dog).