Detalhe da pesquisa
1.
Late-Stage Carbon Isotope Exchange of Aryl Nitriles through Ni-Catalyzed C-CN Bond Activation.
J Am Chem Soc
; 143(12): 4817-4823, 2021 03 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-33725443
2.
Late-Stage 18 O Labeling of Primary Sulfonamides via a Degradation-Reconstruction Pathway.
Chemistry
; 26(19): 4251-4255, 2020 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32003092
3.
Synthesis and evaluation of an AZD2461 [18F]PET probe in non-human primates reveals the PARP-1 inhibitor to be non-blood-brain barrier penetrant.
Bioorg Chem
; 83: 242-249, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30390553
4.
Pd-catalyzed arylation of linear and angular spirodiamine salts under aerobic conditions.
Tetrahedron Lett
; 58(5): 466-469, 2017 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31762498
5.
Evaluation of a Low-Toxicity PARP Inhibitor as a Neuroprotective Agent for Parkinson's Disease.
Mol Neurobiol
; 58(8): 3641-3652, 2021 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-33788167
6.
A Chemical Approach for Programmable Protein Outputs Based on Engineered Cell Interactions.
ACS Chem Biol
; 16(1): 52-57, 2021 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33351606
7.
Ligand with Two Modes of Interaction with the Dopamine D2 Receptor-An Induced-Fit Mechanism of Insurmountable Antagonism.
ACS Chem Neurosci
; 11(19): 3130-3143, 2020 10 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32865974
8.
Improved production of 76Br, 77Br and 80mBr via CoSe cyclotron targets and vertical dry distillation.
Nucl Med Biol
; 80-81: 32-36, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-31575457
9.
Leveraging a Low-Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine D3 Receptor (D3R) Ligand Promiscuity across Highly Conserved Aminergic G-Protein-Coupled Receptors (GPCRs).
J Med Chem
; 62(10): 5132-5147, 2019 05 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31021617
10.
Targeting PARP-1 with Alpha-Particles Is Potently Cytotoxic to Human Neuroblastoma in Preclinical Models.
Mol Cancer Ther
; 18(7): 1195-1204, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31072830
11.
Rapid Cu-Catalyzed [211At]Astatination and [125I]Iodination of Boronic Esters at Room Temperature.
Org Lett
; 20(7): 1752-1755, 2018 04 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29561158
12.
Altering Nitrogen Heterocycles of AZD2461 Affords High Affinity Poly(ADP-ribose) Polymerase-1 Inhibitors with Decreased P-Glycoprotein Interactions.
ACS Omega
; 3(8): 9997-10001, 2018 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-30198004
13.
Examination of Diazaspiro Cores as Piperazine Bioisosteres in the Olaparib Framework Shows Reduced DNA Damage and Cytotoxicity.
J Med Chem
; 61(12): 5367-5379, 2018 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29856625
14.
Highly Selective Dopamine D3 Receptor Antagonists with Arylated Diazaspiro Alkane Cores.
J Med Chem
; 60(23): 9905-9910, 2017 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29125762
15.
Pd-Catalyzed Synthesis of Piperazine Scaffolds Under Aerobic and Solvent-Free Conditions.
Org Lett
; 18(20): 5272-5275, 2016 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-27736075
16.
Transmetallation from CCC-NHC pincer Zr complexes in the synthesis of air-stable CCC-NHC pincer Co(iii) complexes and initial hydroboration trials.
Dalton Trans
; 45(7): 2823-8, 2016 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26814468