1.
Genetics
; 192(2): 753-6, 2012 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22851650
RESUMO
The N-terminal tail of Ndc80 is essential for kinetochore-microtubule binding in human cells but is not required for viability in yeast. We show that the yeast Ndc80 tail is required for timely mitotic progression and accurate chromosome segregation. The tail is essential when cells are limited for Dam1, demonstrating a redundant function for the Ndc80 and Dam1 complexes in vivo.
Assuntos
Proteínas de Ciclo Celular , Cinetocoros/metabolismo , Proteínas Associadas aos Microtúbulos , Proteínas Nucleares , Proteínas de Saccharomyces cerevisiae , Saccharomyces cerevisiae/genética , Proteínas de Ciclo Celular/genética , Proteínas de Ciclo Celular/metabolismo , Segregação de Cromossomos/genética , Proteínas Associadas aos Microtúbulos/genética , Proteínas Associadas aos Microtúbulos/metabolismo , Microtúbulos/genética , Microtúbulos/metabolismo , Mitose/genética , Proteínas Nucleares/genética , Proteínas Nucleares/metabolismo , Fenótipo , Ligação Proteica , Proteínas de Saccharomyces cerevisiae/genética , Proteínas de Saccharomyces cerevisiae/metabolismo
2.
Genetics
; 192(4): 1553-7, 2012 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23051643
RESUMO
There is evidence accumulating for nonrandom segregation of one or more chromosomes during mitosis in different cell types. We use cell synchrony and two methods to show that all chromatids of budding yeast segregate randomly and that there is no mother-daughter bias with respect to Watson and Crick-containing strands of DNA.